ID AKAP3_MOUSE Reviewed; 864 AA. AC O88987; DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 02-OCT-2007, entry version 42. DE A-kinase anchor protein 3 (Protein kinase A-anchoring protein 3) DE (PRKA3) (A-kinase anchor protein 110 kDa) (AKAP 110). GN Name=Akap3; Synonyms=Akap110; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Testis; RX MEDLINE=99252879; PubMed=10319321; DOI=10.1210/me.13.5.705; RA Vijayaraghavan S., Liberty G.A., Mohan J., Winfrey V.P., Olson G.E., RA Carr D.W.; RT "Isolation and molecular characterization of AKAP110, a novel, sperm- RT specific protein kinase A-anchoring protein."; RL Mol. Endocrinol. 13:705-717(1999). CC -!- FUNCTION: May function as a regulator of both motility- and head- CC associated functions such as capacitation and the acrosome CC reaction (By similarity). CC -!- SUBCELLULAR LOCATION: Note=Localizes to the ribs of the fibrous CC sheath in the principal piece of the sperm tail (By similarity). CC -!- DOMAIN: RII-binding site, predicted to form an amphipathic helix, CC could participate in protein-protein interactions with a CC complementary surface on the R-subunit dimer. CC -!- PTM: Phosphorylated on tyrosine (By similarity). CC -!- SIMILARITY: Belongs to the AKAP110 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF093406; AAC63369.1; -; mRNA. DR RefSeq; NP_033780.1; -. DR UniGene; Mm.87748; -. DR Ensembl; ENSMUSG00000030344; Mus musculus. DR GeneID; 11642; -. DR KEGG; mmu:11642; -. DR MGI; MGI:1341149; Akap3. DR ArrayExpress; O88987; -. DR GermOnline; ENSMUSG00000030344; Mus musculus. DR GO; GO:0009434; C:microtubule-based flagellum; IDA:MGI. DR GO; GO:0051018; F:protein kinase A binding; IMP:MGI. DR GO; GO:0006928; P:cell motility; IMP:MGI. DR GO; GO:0008104; P:protein localization; IMP:MGI. DR GO; GO:0007178; P:transmembrane receptor protein serine/threo...; IPI:MGI. DR InterPro; IPR008382; AKAP_110. DR PANTHER; PTHR10226; AKAP_110; 1. DR Pfam; PF05716; AKAP_110; 1. PE 2: Evidence at transcript level; KW Phosphorylation. FT CHAIN 1 864 A-kinase anchor protein 3. FT /FTId=PRO_0000064527. FT REGION 125 138 PKA-RII subunit binding domain. FT MOD_RES 206 206 Phosphoserine (By similarity). FT MOD_RES 405 405 Phosphoserine (By similarity). FT MOD_RES 406 406 Phosphotyrosine (By similarity). SQ SEQUENCE 864 AA; 95586 MW; 3AD5B09DD8E4937D CRC64; MADRVDWLQS QSGVCKVGVY SPGDNQHQDW KMDTSTDPVR VLSWLRKDLE KSTAGFQDSR FKPGESSFVE EVAYPVDQRK GFCVDYYNTT NKGSPGRLHF EMSHKENPSQ GLISHVGNGG SIDEVSFYAN RLTNLVIAMA RKEINEKIHG AENKCVHQSL YMGDEPTPHK SLSTVASELV NETVTACSKN ISSDKAPGSG DRASGSSQAP GLRYMSTLKI KESTKEGKCP DDKPGTKKSF FYKEVFESRN AGDAKEGGRS LPGDQKLFRT SPDNRPDDFS NSISQGIMTY ANSVVSDMMV SIMKTLKIQV KDTTIATILL KKVLMKHAKE VVSDLIDSFM KNLHGVTGSL MTDTDFVSAV KRSFFSHGSQ KATDIMDAML GKLYNVMFAK KFPENIRRAR DKSESYSLIS TKSRAGDPKL SNLNFAMKSE SKLKENLFST CKLEKEKTCA ETLGEHIIKE GLHMWHKSQQ KSPGLERAAK LGNAPQEVSF ECPDPCEANP PHQPQPPENF ANFMCDSDSW AKDLIVSALL LIQYHLAQGG KMDAQSFLEA AASTNFPTNK PPPPSPVVQD ECKLKSPPHK ICDQEQTEKK DLMSVIFNFI RNLLSETIFK SSRNCESNVH EQNTQEEEIH PCERPKTPCE RPITPPAPKF CEDEEATGGA LSGLTKMVAN QLDNCMNGQM VEHLMDSVMK LCLIIAKSCD SPLSELGEEK CGDASRPNSA FPDNLYECLP VKGTGTAEAL LQNAYLTIHN ELRGLSGQPP EGCEIPKVIV SNHNLADTVQ NKQLQAVLQW VAASELNVPI LYFAGDDEGI QEKLLQLSAT AVEKGRSVGE VLQSVLRYEK ERQLDEAVGN VTRLQLLDWL MANL //