ID AKA3_MOUSE STANDARD; PRT; 864 AA. AC O88987; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE A-kinase anchor protein 3 (Protein kinase A anchoring protein 3) DE (PRKA3) (A-kinase anchor protein 110 kDa) (AKAP 110). GN AKAP3 OR AKAP110. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Testis; RX MEDLINE=99252879; PubMed=10319321; RA Vijayaraghavan S., Liberty G.A., Mohan J., Winfrey V.P., Olson G.E., RA Carr D.W.; RT "Isolation and molecular characterization of AKAP110, a novel, RT sperm-specific protein kinase A-anchoring protein."; RL Mol. Endocrinol. 13:705-717(1999). CC -!- FUNCTION: MAY FUNCTION AS A REGULATOR OF BOTH MOTILITY- AND HEAD- CC ASSOCIATED FUNCTIONS SUCH AS CAPACITATION AND THE ACROSOME CC REACTION (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: LOCALIZES TO THE RIBS OF THE FIBROUS SHEATH CC IN THE PRINCIPAL PIECE OF THE SPERM TAIL (BY SIMILARITY). CC -!- DOMAIN: RII-BINDING SITE, PREDICTED TO FORM AN AMPHIPATHIC CC HELIX, COULD PARTICIPATE IN PROTEIN-PROTEIN INTERACTIONS WITH A CC COMPLEMENTARY SURFACE ON THE R-SUBUNIT DIMER. CC -!- PTM: Phosphorylated on tyrosine (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF093406; AAC63369.1; -. DR MGD; MGI:1341149; Akap3. DR GO; GO:0005079; F:protein kinase A anchor protein activity; IMP. DR GO; GO:0006928; P:cell motility; IMP. DR GO; GO:0007178; P:transmembrane receptor protein serine/threo...; IPI. KW Phosphorylation. FT DOMAIN 125 138 PKA-RII SUBUNIT BINDING DOMAIN. SQ SEQUENCE 864 AA; 95586 MW; 3AD5B09DD8E4937D CRC64; MADRVDWLQS QSGVCKVGVY SPGDNQHQDW KMDTSTDPVR VLSWLRKDLE KSTAGFQDSR FKPGESSFVE EVAYPVDQRK GFCVDYYNTT NKGSPGRLHF EMSHKENPSQ GLISHVGNGG SIDEVSFYAN RLTNLVIAMA RKEINEKIHG AENKCVHQSL YMGDEPTPHK SLSTVASELV NETVTACSKN ISSDKAPGSG DRASGSSQAP GLRYMSTLKI KESTKEGKCP DDKPGTKKSF FYKEVFESRN AGDAKEGGRS LPGDQKLFRT SPDNRPDDFS NSISQGIMTY ANSVVSDMMV SIMKTLKIQV KDTTIATILL KKVLMKHAKE VVSDLIDSFM KNLHGVTGSL MTDTDFVSAV KRSFFSHGSQ KATDIMDAML GKLYNVMFAK KFPENIRRAR DKSESYSLIS TKSRAGDPKL SNLNFAMKSE SKLKENLFST CKLEKEKTCA ETLGEHIIKE GLHMWHKSQQ KSPGLERAAK LGNAPQEVSF ECPDPCEANP PHQPQPPENF ANFMCDSDSW AKDLIVSALL LIQYHLAQGG KMDAQSFLEA AASTNFPTNK PPPPSPVVQD ECKLKSPPHK ICDQEQTEKK DLMSVIFNFI RNLLSETIFK SSRNCESNVH EQNTQEEEIH PCERPKTPCE RPITPPAPKF CEDEEATGGA LSGLTKMVAN QLDNCMNGQM VEHLMDSVMK LCLIIAKSCD SPLSELGEEK CGDASRPNSA FPDNLYECLP VKGTGTAEAL LQNAYLTIHN ELRGLSGQPP EGCEIPKVIV SNHNLADTVQ NKQLQAVLQW VAASELNVPI LYFAGDDEGI QEKLLQLSAT AVEKGRSVGE VLQSVLRYEK ERQLDEAVGN VTRLQLLDWL MANL //