ID O77579_BOVIN Unreviewed; 530 AA. AC O77579; DT 01-NOV-1998, integrated into UniProtKB/TrEMBL. DT 01-NOV-1998, sequence version 1. DT 19-JAN-2022, entry version 91. DE RecName: Full=Alkaline phosphatase {ECO:0000256|ARBA:ARBA00012647, ECO:0000256|RuleBase:RU003947}; DE EC=3.1.3.1 {ECO:0000256|ARBA:ARBA00012647, ECO:0000256|RuleBase:RU003947}; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAC33854.1}; RN [1] {ECO:0000313|EMBL:AAC33854.1} RP NUCLEOTIDE SEQUENCE. RA Manes T., Hoylaerts M.F., Muller R., Lottspeich F., Hoelke W., Millan J.L.; RT "Bovine alkaline phosphatases."; RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a phosphate monoester + H2O = an alcohol + phosphate; CC Xref=Rhea:RHEA:15017, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:67140; EC=3.1.3.1; CC Evidence={ECO:0000256|RuleBase:RU003947}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor CC {ECO:0000256|ARBA:ARBA00004589}. CC -!- SIMILARITY: Belongs to the alkaline phosphatase family. CC {ECO:0000256|ARBA:ARBA00005984, ECO:0000256|RuleBase:RU003946}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF052227; AAC33854.1; -; mRNA. DR OMA; FEYSHME; -. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004035; F:alkaline phosphatase activity; IEA:UniProtKB-EC. DR CDD; cd16012; ALP; 1. DR Gene3D; 3.40.720.10; -; 1. DR InterPro; IPR001952; Alkaline_phosphatase. DR InterPro; IPR018299; Alkaline_phosphatase_AS. DR InterPro; IPR017850; Alkaline_phosphatase_core_sf. DR PANTHER; PTHR11596; PTHR11596; 1. DR Pfam; PF00245; Alk_phosphatase; 1. DR PRINTS; PR00113; ALKPHPHTASE. DR SMART; SM00098; alkPPc; 1. DR SUPFAM; SSF53649; SSF53649; 1. DR PROSITE; PS00123; ALKALINE_PHOSPHATASE; 1. PE 2: Evidence at transcript level; KW Glycoprotein {ECO:0000256|ARBA:ARBA00022622}; KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622}; KW Hydrolase {ECO:0000256|RuleBase:RU003947, ECO:0000313|EMBL:AAC33854.1}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU003947}; KW Membrane {ECO:0000256|ARBA:ARBA00022622}; Signal {ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU003947}. FT SIGNAL 1..19 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 20..530 FT /note="Alkaline phosphatase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5004159869" SQ SEQUENCE 530 AA; 57106 MW; F8FEAB1D4D33D1F4 CRC64; MQWACVLLLL GLWLQLSLTF IPAEEEDPAF WNRQAAQALD VAKKLQPIQT AAKNVILFLG DGMGVPTVTA TRILKGQMNG KLGPETPLAM DQFPYVALSK TYNVDRQVPD SAGTATAYLC GVKGNYKTIG VSAAARYNQC NTTSGNEVTS VMNRAKKAGK SVGVVTTSRV QHASPAGAYA HTVNRNWYSD ADLPADAQTY GCQDIATQLV NNMDIDVILG GGRMYMFPEG TPDPEYPYDV NQTGVRKDKR NLVQEWQAKH QGAQYVWNRT ELLQAANDPS VTHLMGLFEP ADMKYNVQQD PTKDPTLEEM TEAALQVLSR NPQGFYLFVE GGRIDHGHHE GKAYMALTDT VMFDNAIAKA NELTSELDTL ILATADHSHV FSFGGYTLRG TSIFGLAPSK ASDNKSYTSI LYGNGPGYVL GGGLRPDVND SISEDPSYRQ QAAVPLSSES HGGEDVAVFA RGPQAHLVHG VQEETFVAHV MAFAGCVEPY TDCNLPAPSG LSDAAHLAAS PPSLALLAGA MLLLLAPALY //