ID O77240_CHOFU Unreviewed; 513 AA. AC O77240; DT 01-NOV-1998, integrated into UniProtKB/TrEMBL. DT 01-MAY-2000, sequence version 2. DT 14-DEC-2022, entry version 119. DE RecName: Full=Ecdysone receptor {ECO:0000256|ARBA:ARBA00022052}; DE AltName: Full=20-hydroxy-ecdysone receptor {ECO:0000256|ARBA:ARBA00029963}; DE AltName: Full=EcRH {ECO:0000256|ARBA:ARBA00030794}; DE AltName: Full=Ecdysteroid receptor {ECO:0000256|ARBA:ARBA00033003}; DE AltName: Full=Nuclear receptor subfamily 1 group H member 1 {ECO:0000256|ARBA:ARBA00033286}; GN Name=EcR {ECO:0000313|EMBL:AAC61596.2}; OS Choristoneura fumiferana (Spruce budworm moth) (Archips fumiferana). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Tortricoidea; OC Tortricidae; Tortricinae; Choristoneura. OX NCBI_TaxID=7141 {ECO:0000313|EMBL:AAC61596.2}; RN [1] {ECO:0000313|EMBL:AAC61596.2} RP NUCLEOTIDE SEQUENCE. RX PubMed=10432225; DOI=10.1016/S0303-7207(99)00058-1; RA Perera S.C., Ladd T.R., Dhadialla T.S., Krell P.J., Sohi S.S., RA Retnakaran A., Palli S.R.; RT "Studies on two ecdysone receptor isoforms of the spruce budworm, RT Choristoneura fumiferana."; RL Mol. Cell. Endocrinol. 152:73-84(1999). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123, CC ECO:0000256|PROSITE-ProRule:PRU00407, ECO:0000256|RuleBase:RU004334}. CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 CC subfamily. {ECO:0000256|ARBA:ARBA00008092}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF092030; AAC61596.2; -; mRNA. DR AlphaFoldDB; O77240; -. DR BindingDB; O77240; -. DR ChEMBL; CHEMBL4113; -. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0035100; F:ecdysone binding; IEA:InterPro. DR GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro. DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0035076; P:ecdysone receptor-mediated signaling pathway; IEA:InterPro. DR CDD; cd06938; NR_LBD_EcR; 1. DR Gene3D; 1.10.565.10; -; 1. DR Gene3D; 3.30.50.10; -; 1. DR InterPro; IPR003069; Ecdystd_rcpt. DR InterPro; IPR035500; NHR-like_dom_sf. DR InterPro; IPR041889; NR_LBD_EcR. DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd. DR InterPro; IPR001723; Nuclear_hrmn_rcpt. DR InterPro; IPR001628; Znf_hrmn_rcpt. DR InterPro; IPR013088; Znf_NHR/GATA. DR Pfam; PF00104; Hormone_recep; 1. DR Pfam; PF00105; zf-C4; 1. DR PRINTS; PR01283; ECDYSTEROIDR. DR PRINTS; PR00398; STRDHORMONER. DR PRINTS; PR00047; STROIDFINGER. DR SMART; SM00430; HOLI; 1. DR SMART; SM00399; ZnF_C4; 1. DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1. DR PROSITE; PS51843; NR_LBD; 1. DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1. DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1. PE 2: Evidence at transcript level; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE- KW ProRule:PRU00407}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|RuleBase:RU004334}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE- KW ProRule:PRU00407}; KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334}; KW Transcription {ECO:0000256|ARBA:ARBA00023163, ECO:0000256|PROSITE- KW ProRule:PRU00407}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015, KW ECO:0000256|PROSITE-ProRule:PRU00407}; KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00407}. FT DOMAIN 110..185 FT /note="Nuclear receptor" FT /evidence="ECO:0000259|PROSITE:PS51030" FT DOMAIN 259..497 FT /note="NR LBD" FT /evidence="ECO:0000259|PROSITE:PS51843" FT DNA_BIND 110..185 FT /note="Nuclear receptor" FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00407" FT REGION 20..104 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 200..219 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 47..71 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 513 AA; 57622 MW; F110540A3030E602 CRC64; MDLKHEVAYR GVLPGQVKAE PGVHNGQVNG HVRDWMAGGA GANSPSPGAV AQPQPNNGYS SPLSSGSYGP YSPNGKIGRE ELSPASSING CSTDGEARRQ KKGPAPRQQE ELCLVCGDRA SGYHYNALTC EGCKGFFRRS VTKNAVYICK FGHACEMDMY MRRKCQECRL KKCLAVGMRP ECVVPETQCA MKRKEKKAQK EKDKLPVSTT TVDDHMPPIM QCEPPPPEAA RIHEVVPRFL SDKLLETNRQ KNIPQLTANQ QFLIARLIWY QDGYEQPSDE DLKRITQTWQ QADDENEESD TPFRQITEMT ILTVQLIVEF AKGLPGFAKI SQPDQITLLK ACSSEVMMLR VARRYDAASD SVLFANNQAY TRDNYRKAGM AYVIEDLLHF CRCMYSMALD NIHYALLTAV VIFSDRPGLE QPQLVEEIQR YYLNTLRIYI LNQLSGSARS SVIYGKILSI LSELRTLGMQ NSNMCISLKL KNRKLPPFLE EIWDVADMSH TQPPPILESP TNL //