ID O76268_DROME Unreviewed; 461 AA. AC O76268; DT 01-NOV-1998, integrated into UniProtKB/TrEMBL. DT 01-NOV-1998, sequence version 1. DT 13-SEP-2023, entry version 171. DE SubName: Full=LD11641p {ECO:0000313|EMBL:AAL28682.1}; DE SubName: Full=NTPDase 6 {ECO:0000313|EMBL:ACF58165.1}; DE SubName: Full=NTPase {ECO:0000313|EMBL:AAC39133.1}; DE SubName: Full=NTPase, isoform A {ECO:0000313|EMBL:AAF51182.1}; DE EC=3.6.1.42 {ECO:0000313|EMBL:AAF51182.1}; DE EC=3.6.1.6 {ECO:0000313|EMBL:AAF51182.1}; DE EC=3.6.1.64 {ECO:0000313|EMBL:AAF51182.1}; GN Name=NTPase {ECO:0000313|EMBL:AAF51182.1, GN ECO:0000313|FlyBase:FBgn0024947}; GN Synonyms=Dmel\CG3059 {ECO:0000313|EMBL:AAF51182.1}, dmNTPase GN {ECO:0000313|EMBL:AAF51182.1}, NTPDase6 {ECO:0000313|EMBL:AAF51182.1}; GN ORFNames=CG3059 {ECO:0000313|EMBL:AAF51182.1, GN ECO:0000313|FlyBase:FBgn0024947}, Dmel_CG3059 GN {ECO:0000313|EMBL:AAF51182.1}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:AAF51182.1, ECO:0000313|Proteomes:UP000000803}; RN [1] {ECO:0000313|EMBL:AAC39133.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=9676430; DOI=10.1006/geno.1998.5317; RA Chadwick B.P., Frischauf A.-M.; RT "The CD39-like gene family: identification of three new human members RT (CD39L2, CD39L3, and CD39L4), their murine homologues, and a member of the RT gene family from Drosophila melanogaster."; RL Genomics 50:357-367(1998). RN [2] {ECO:0000313|EMBL:AAF51182.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=10731132; DOI=10.1126/science.287.5461.2185; RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.; RT "The genome sequence of Drosophila melanogaster."; RL Science 287:2185-2195(2000). RN [3] {ECO:0000313|EMBL:AAL28682.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=Berkeley {ECO:0000313|EMBL:AAL28682.1}; RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J., Champe M., RA Chavez C., Dorsett V., Farfan D., Frise E., George R., Gonzalez M., RA Guarin H., Li P., Liao G., Miranda A., Mungall C.J., Nunoo J., Pacleb J., RA Paragas V., Park S., Phouanenavong S., Wan K., Yu C., Lewis S.E., RA Rubin G.M., Celniker S.; RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537568; RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A., RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A., RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R., RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J., RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C., RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.; RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster RT euchromatic genome sequence."; RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002). RN [5] {ECO:0000313|Proteomes:UP000000803} RP GENOME REANNOTATION. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083; RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., RA Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P., RA Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A., Harris N.L., RA Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., RA Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.; RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic RT review."; RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002). RN [6] {ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537573; RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R., RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M., RA Celniker S.E.; RT "The transposable elements of the Drosophila melanogaster euchromatin: a RT genomics perspective."; RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002). RN [7] {ECO:0000313|EMBL:AAF51182.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=12537574; RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A., RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G., RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M., RA Karpen G.H.; RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly."; RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002). RN [8] {ECO:0000313|EMBL:AAF51182.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022; RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D., RA Ashburner M., Anxolabehere D.; RT "Combined evidence annotation of transposable elements in genome RT sequences."; RL PLoS Comput. Biol. 1:166-175(2005). RN [9] {ECO:0000313|EMBL:AAF51182.1} RP NUCLEOTIDE SEQUENCE. RA Celniker S., Carlson J., Wan K., Frise E., Hoskins R., Park S., RA Svirskas R., Rubin G.; RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:AAF51182.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569856; DOI=10.1126/science.1139815; RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.; RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin."; RL Science 316:1586-1591(2007). RN [11] {ECO:0000313|EMBL:AAF51182.1, ECO:0000313|Proteomes:UP000000803} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803}; RX PubMed=17569867; DOI=10.1126/science.1139816; RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M., RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A., RA Dimitri P., Karpen G.H., Celniker S.E.; RT "Sequence finishing and mapping of Drosophila melanogaster RT heterochromatin."; RL Science 316:1625-1628(2007). RN [12] {ECO:0000313|EMBL:ACF58165.1} RP NUCLEOTIDE SEQUENCE. RA Knowles A.F.; RT "The single NTPase gene of Drosophila melanogaster encodes an intracellular RT nucleoside triphosphate diphosphohydrolase 6 (NTPDase6)."; RL Arch. Biochem. Biophys. 484:70-79(2009). RN [13] {ECO:0000313|EMBL:AAF51182.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109357; DOI=.1534/g3.115.018929; RG FlyBase Consortium; RA Matthews B.B., Dos Santos G., Crosby M.A., Emmert D.B., St Pierre S.E., RA Gramates L.S., Zhou P., Schroeder A.J., Falls K., Strelets V., Russo S.M., RA Gelbart W.M., null; RT "Gene Model Annotations for Drosophila melanogaster: Impact of High- RT Throughput Data."; RL G3 (Bethesda) 5:1721-1736(2015). RN [14] {ECO:0000313|EMBL:AAF51182.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=26109356; DOI=.1534/g3.115.018937; RG FlyBase Consortium; RA Crosby M.A., Gramates L.S., Dos Santos G., Matthews B.B., St Pierre S.E., RA Zhou P., Schroeder A.J., Falls K., Emmert D.B., Russo S.M., Gelbart W.M., RA null; RT "Gene Model Annotations for Drosophila melanogaster: The Rule-Benders."; RL G3 (Bethesda) 5:1737-1749(2015). RN [15] {ECO:0000313|EMBL:AAF51182.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=25589440; RA Hoskins R.A., Carlson J.W., Wan K.H., Park S., Mendez I., Galle S.E., RA Booth B.W., Pfeiffer B.D., George R.A., Svirskas R., Krzywinski M., RA Schein J., Accardo M.C., Damia E., Messina G., Mendez-Lago M., RA de Pablos B., Demakova O.V., Andreyeva E.N., Boldyreva L.V., Marra M., RA Carvalho A.B., Dimitri P., Villasante A., Zhimulev I.F., Rubin G.M., RA Karpen G.H., Celniker S.E.; RT "The Release 6 reference sequence of the Drosophila melanogaster genome."; RL Genome Res. 25:445-458(2015). RN [16] {ECO:0000313|EMBL:AAF51182.1} RP NUCLEOTIDE SEQUENCE. RG Berkeley Drosophila Genome Project; RA Celniker S., Carlson J., Wan K., Pfeiffer B., Frise E., George R., RA Hoskins R., Stapleton M., Pacleb J., Park S., Svirskas R., Smith E., Yu C., RA Rubin G.; RT "Drosophila melanogaster release 4 sequence."; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:AAF51182.1} RP NUCLEOTIDE SEQUENCE. RG FlyBase; RL Submitted (NOV-2022) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family. CC {ECO:0000256|ARBA:ARBA00009283}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF041048; AAC39133.1; -; Genomic_DNA. DR EMBL; AE014134; AAF51182.1; -; Genomic_DNA. DR EMBL; AY061134; AAL28682.1; -; mRNA. DR EMBL; EU852293; ACF58165.1; -; mRNA. DR RefSeq; NP_477370.1; NM_058022.5. DR AlphaFoldDB; O76268; -. DR SMR; O76268; -. DR DNASU; 33495; -. DR EnsemblMetazoa; FBtr0077683; FBpp0077367; FBgn0024947. DR GeneID; 33495; -. DR UCSC; CG3059-RA; d. melanogaster. DR AGR; FB:FBgn0024947; -. DR CTD; 33495; -. DR FlyBase; FBgn0024947; NTPase. DR VEuPathDB; VectorBase:FBgn0024947; -. DR GeneTree; ENSGT01070000253757; -. DR OrthoDB; 180318at2759; -. DR BioGRID-ORCS; 33495; 0 hits in 3 CRISPR screens. DR ChiTaRS; NTPase; fly. DR GenomeRNAi; 33495; -. DR Proteomes; UP000000803; Chromosome 2L. DR Bgee; FBgn0024947; Expressed in adult midgut (Drosophila) and 29 other tissues. DR GO; GO:0005737; C:cytoplasm; IDA:FlyBase. DR GO; GO:0016020; C:membrane; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004382; F:GDP phosphatase activity; IDA:FlyBase. DR GO; GO:0045134; F:UDP phosphatase activity; IDA:FlyBase. DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central. DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1. DR Gene3D; 3.30.420.40; -; 1. DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1. DR InterPro; IPR000407; GDA1_CD39_NTPase. DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1. DR PANTHER; PTHR11782:SF3; NTPASE, ISOFORM F; 1. DR Pfam; PF01150; GDA1_CD39; 1. PE 1: Evidence at protein level; KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AAF51182.1}; KW Membrane {ECO:0000256|SAM:Phobius}; KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2}; KW Proteomics identification {ECO:0007829|PeptideAtlas:O76268}; KW Reference proteome {ECO:0000313|Proteomes:UP000000803}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT TRANSMEM 38..57 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT REGION 9..31 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT ACT_SITE 202 FT /note="Proton acceptor" FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1" FT BINDING 230..234 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2" SQ SEQUENCE 461 AA; 50845 MW; 27D00321F91A9DD1 CRC64; MKYEYKLLAT DEKPPRRKSS GSPNASSGGN RGPSGLKISF LCLIISVILL LFVFGFVSEN ASPYLARLAS KFGYSKVQYA AIIDAGSTGS RVLAYKFNRS FIDNKLVLYE ELFKERKPGL SSFADNPAEG AHSIKLLLDE ARAFIPKEHW SSTPLVLKAT AGLRLLPASK AENILNAVRD LFAKSEFSVD MDAVEIMDGT DEGIFSWFTV NFLLGRLSKT NQAAALDLGG GSTQVTFSPT DPDQVPVYDK YMHEVVTSSK KINVFTHSYL GLGLMAARHA VFTHGYKKED TVLESVCVNP IIANRTWTYG NVQYKVSGKE NGKSSAEQPI VDFDACLELV KSKVMPLVKP KPFTLKQHAV AAFSYYFERA IESGLVDPLA GGETTVEAYR KKAQEICAIP NDEQPFMCFD LTFISTLLRE GFGLNDGKKI KLYKKIDGHE ISWALGCAYN VLTSDEKFSN S //