ID   OR7AA_HUMAN             Reviewed;         309 AA.
AC   O76100; Q6IFP0; Q96R97;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   23-FEB-2022, entry version 162.
DE   RecName: Full=Olfactory receptor 7A10;
DE   AltName: Full=OST027;
DE   AltName: Full=Olfactory receptor OR19-18;
GN   Name=OR7A10;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Sperm;
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR7A10";
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DR   EMBL; AC005255; AAC25627.1; -; Genomic_DNA.
DR   EMBL; AF399542; AAK95027.1; -; Genomic_DNA.
DR   EMBL; BK004222; DAA04620.1; -; Genomic_DNA.
DR   CCDS; CCDS32936.1; -.
DR   RefSeq; NP_001005190.1; NM_001005190.1.
DR   SMR; O76100; -.
DR   BioGRID; 133724; 2.
DR   IntAct; O76100; 1.
DR   STRING; 9606.ENSP00000248058; -.
DR   GlyGen; O76100; 1 site.
DR   BioMuta; OR7A10; -.
DR   PaxDb; O76100; -.
DR   PeptideAtlas; O76100; -.
DR   PRIDE; O76100; -.
DR   TopDownProteomics; O76100; -.
DR   Antibodypedia; 59282; 46 antibodies from 14 providers.
DR   DNASU; 390892; -.
DR   Ensembl; ENST00000641129; ENSP00000493055; ENSG00000127515.
DR   GeneID; 390892; -.
DR   KEGG; hsa:390892; -.
DR   MANE-Select; ENST00000641129.1; ENSP00000493055.1; NM_001005190.2; NP_001005190.1.
DR   UCSC; uc002mzx.1; human.
DR   CTD; 390892; -.
DR   GeneCards; OR7A10; -.
DR   HGNC; HGNC:8356; OR7A10.
DR   HPA; ENSG00000127515; Not detected.
DR   neXtProt; NX_O76100; -.
DR   PharmGKB; PA32611; -.
DR   VEuPathDB; HostDB:ENSG00000127515; -.
DR   eggNOG; ENOG502RTYS; Eukaryota.
DR   GeneTree; ENSGT00940000153523; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; O76100; -.
DR   OMA; KRFFRGK; -.
DR   OrthoDB; 984499at2759; -.
DR   PhylomeDB; O76100; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; O76100; -.
DR   SignaLink; O76100; -.
DR   BioGRID-ORCS; 390892; 197 hits in 574 CRISPR screens.
DR   ChiTaRS; OR7A10; human.
DR   GeneWiki; OR7A10; -.
DR   GenomeRNAi; 390892; -.
DR   Pharos; O76100; Tdark.
DR   PRO; PR:O76100; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O76100; protein.
DR   Bgee; ENSG00000127515; Expressed in zone of skin and 11 other tissues.
DR   ExpressionAtlas; O76100; baseline and differential.
DR   Genevisible; O76100; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 7A10"
FT                   /id="PRO_0000150644"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         151
FT                   /note="M -> T (in dbSNP:rs12972670)"
FT                   /id="VAR_053225"
FT   VARIANT         183
FT                   /note="Q -> E (in dbSNP:rs9305052)"
FT                   /id="VAR_034254"
FT   VARIANT         225
FT                   /note="I -> L (in dbSNP:rs11880955)"
FT                   /id="VAR_053226"
FT   VARIANT         273
FT                   /note="A -> T (in dbSNP:rs10221530)"
FT                   /id="VAR_053227"
FT   CONFLICT        70
FT                   /note="D -> G (in Ref. 2; AAK95027)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   309 AA;  34406 MW;  8761B3C97FE3ADB1 CRC64;
     MKSWNNTIIL EFLLLGISEE PELQAFLFGL FLSMYLVTVL GNLLIILATI SDSHLHTPMY
     FFLSNLSFVD ICFVSTTVPK MLVNIQTHNK VITYAGCITQ MCFFLLFVGL DNFLLTVMAY
     DRFVAICHPL HYMVIMNPQL CGLLVLASWI MSVLNSMLQS LMVLPLPFCT HMEIPHFFCE
     INQVVHLACS DTFLNDIVMY FAVALLGGGP LTGILYSYSK IVSSIRAISS AQGKYKAFST
     CASHLSVVSL FYGTCLGVYL SSAATHNSHT GAAASVMYTV VTPMLNPFIY SLRNKHIKGA
     MKTFFRGKQ
//