ID O75883 PRELIMINARY; PRT; 467 AA. AC O75883; DT 01-NOV-1998 (TrEMBLrel. 08, Created) DT 01-NOV-1998 (TrEMBLrel. 08, Last sequence update) DT 01-MAY-1999 (TrEMBLrel. 10, Last annotation update) DE REGULATOR OF G-PROTEIN SIGNALING 11. GN RGS11. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RX MEDLINE; 99007310. RA SNOW B.E., KRUMINS A.M., BROTHERS G.M., LEE S.-F., WALL M.A., RA CHUNG S., MANGION J., ARYA S., GILMAN A.G., SIDEROVSKI D.P.; RT "A G protein gamma subunit-like (GGL) domain shared between RGS11 and RT other RGS proteins specifies binding to G beta 5 subunits."; RL Proc. Natl. Acad. Sci. U.S.A. 27:13307-13312(1998). CC -!- FUNCTION: INHIBITS SIGNAL TRANSDUCTION BY INCREASING THE GTPASE CC ACTIVITY OF G PROTEIN ALPHA SUBUNITS THEREBY DRIVING THEM INTO CC THEIR INACTIVE GDP-BOUND FORM. CC -!- SUBUNIT: HETERODIMER OF A GBETA5 AND A RGS11 SUBUNITS. CC -!- SIMILARITY: BELONGS TO THE RGS FAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF035153; AAC69175.1; -. DR EMBL; AF035154; AAC69176.1; -. DR PFAM; PF00610; DEP; 1. DR PFAM; PF00615; RGS; 1. KW Signal transduction inhibitor. FT DOMAIN 32 113 DISHEVELLED/EG1-10/PLECKSTRIN (DEP). FT DOMAIN 219 282 G-GAMMA-LIKE (GGL). FT DOMAIN 299 414 REGULATOR OF G-PROTEIN SIGNALING (RGS). SQ SEQUENCE 467 AA; 52946 MW; 060681CC CRC32; MAAGPAPPPG RPRAQMPHLR KMERVVVSMQ DPDQGVKMRS QRLLVTVIPH AVTGSDVVQW LAQKFCVSEE EALHLGAVLV QHGYIYPLRD PRSLMLRPDE TPYRFQTPYF WTSTLRPAAE LDYAIYLAKK NIRKRGTLVD YEKDCYDRLH KKINHAWDLV LMQAREQLRA AKQRSKGDRL VIACQEQTYW LVNRPPPGAP DVLEQGPGRG SCAASRVLMT KSADFHKREI EYFRKALGRT RVKSSVCLEA YLSFCGQRGP HDPLVSGCLP SNPWISDNDA YWVMNAPTVA APTKLRVERW GFSFRELLED PVGRAHFMDF LGKEFSGENL SFWEACEELR YGAQAQVPTL VDAVYEQFLA PGAAHWVNID SRTMEQTLEG LRQPHRYVLD DAQLHIYMLM KKDSYPRFLK SDMYKALLAE AGIPLEMKRR VFPFTWRPRH SSPSPALLPT PVEPTAACGP GGGDGVA //