ID KRA58_HUMAN Reviewed; 187 AA. AC O75690; Q6L8G7; Q6UTX6; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 21-DEC-2004, sequence version 2. DT 03-MAY-2023, entry version 142. DE RecName: Full=Keratin-associated protein 5-8; DE AltName: Full=Keratin, ultra high-sulfur matrix protein B; DE AltName: Full=Keratin-associated protein 5.8; DE AltName: Full=UHS keratin B; DE Short=UHS KerB; DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.8; GN Name=KRTAP5-8; Synonyms=KAP5.8, KRTAP5.8, UHSKB; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=10023043; DOI=10.1016/s0378-1119(98)00616-7; RA Perez C., Auriol J., Gerst C., Bernard B.A., Egly J.-M.; RT "Genomic organization and promoter characterization of two human UHS RT keratin genes."; RL Gene 227:137-148(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY. RC TISSUE=Hair root; RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074; RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J., RA Shimizu N.; RT "Identification of two novel clusters of ultrahigh-sulfur keratin- RT associated protein genes on human chromosome 11."; RL Biochem. Biophys. Res. Commun. 318:655-664(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Zhou G., Yu R., Li H., Shen C., Li M., Xiao W., Zhong G., Lin L., Yang S.; RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are CC embedded in an interfilamentous matrix, consisting of hair keratin- CC associated protein (KRTAP), which are essential for the formation of a CC rigid and resistant hair shaft through their extensive disulfide bond CC cross-linking with abundant cysteine residues of hair keratins. The CC matrix proteins include the high-sulfur and high-glycine-tyrosine CC keratins. CC -!- INTERACTION: CC O75690; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-12134621, EBI-713677; CC O75690; Q03014: HHEX; NbExp=3; IntAct=EBI-12134621, EBI-747421; CC O75690; O96014: WNT11; NbExp=3; IntAct=EBI-12134621, EBI-8058160; CC -!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any other CC tissues. Expressed in cuticle layers of differentiating hair follicles. CC {ECO:0000269|PubMed:15144888}. CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ006692; CAA07188.1; -; Genomic_DNA. DR EMBL; AB126077; BAD20204.1; -; mRNA. DR EMBL; AY360461; AAQ62965.1; -; mRNA. DR CCDS; CCDS41683.1; -. DR RefSeq; NP_066384.2; NM_021046.2. DR AlphaFoldDB; O75690; -. DR BioGRID; 121789; 3. DR IntAct; O75690; 3. DR STRING; 9606.ENSP00000420723; -. DR iPTMnet; O75690; -. DR PhosphoSitePlus; O75690; -. DR BioMuta; KRTAP5-8; -. DR PaxDb; O75690; -. DR PeptideAtlas; O75690; -. DR Antibodypedia; 77457; 1 antibodies from 1 providers. DR DNASU; 57830; -. DR Ensembl; ENST00000398534.4; ENSP00000420723.1; ENSG00000241233.4. DR GeneID; 57830; -. DR KEGG; hsa:57830; -. DR MANE-Select; ENST00000398534.4; ENSP00000420723.1; NM_021046.3; NP_066384.2. DR UCSC; uc001oqr.1; human. DR AGR; HGNC:23603; -. DR CTD; 57830; -. DR GeneCards; KRTAP5-8; -. DR HGNC; HGNC:23603; KRTAP5-8. DR HPA; ENSG00000241233; Group enriched (kidney, skin). DR neXtProt; NX_O75690; -. DR OpenTargets; ENSG00000241233; -. DR PharmGKB; PA134954599; -. DR VEuPathDB; HostDB:ENSG00000241233; -. DR eggNOG; KOG4726; Eukaryota. DR GeneTree; ENSGT00940000164776; -. DR HOGENOM; CLU_097966_0_0_1; -. DR OMA; AWSKPSC; -. DR PathwayCommons; O75690; -. DR Reactome; R-HSA-6805567; Keratinization. DR SignaLink; O75690; -. DR BioGRID-ORCS; 57830; 150 hits in 1039 CRISPR screens. DR GenomeRNAi; 57830; -. DR Pharos; O75690; Tdark. DR PRO; PR:O75690; -. DR Proteomes; UP000005640; Chromosome 11. DR RNAct; O75690; protein. DR Bgee; ENSG00000241233; Expressed in periodontal ligament and 77 other tissues. DR Genevisible; O75690; HS. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR GO; GO:0030280; F:structural constituent of skin epidermis; NAS:UniProtKB. PE 1: Evidence at protein level; KW Keratin; Reference proteome; Repeat. FT CHAIN 1..187 FT /note="Keratin-associated protein 5-8" FT /id="PRO_0000184106" FT REPEAT 28..31 FT /note="1" FT REPEAT 34..37 FT /note="2" FT REPEAT 40..43 FT /note="3" FT REPEAT 109..112 FT /note="4" FT REPEAT 119..122 FT /note="5" FT REPEAT 138..141 FT /note="6" FT REPEAT 148..151 FT /note="7" FT REPEAT 167..170 FT /note="8" FT REPEAT 177..180 FT /note="9" FT REGION 28..180 FT /note="9 X 4 AA repeats of C-C-X-P" FT VARIANT 28 FT /note="C -> R (in dbSNP:rs55921335)" FT /id="VAR_062156" FT CONFLICT 27..28 FT /note="SC -> GCGGCGSSR (in Ref. 1; CAA07188)" FT /evidence="ECO:0000305" FT CONFLICT 29 FT /note="C -> R (in Ref. 3; AAQ62965)" FT /evidence="ECO:0000305" FT CONFLICT 91 FT /note="Y -> C (in Ref. 3; AAQ62965)" FT /evidence="ECO:0000305" SQ SEQUENCE 187 AA; 17519 MW; 4FFD0AEC2D37432A CRC64; MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCSSC GSCGGSKGGR GSCGGSKGDC GSCGGSKGGC GSCGCSQCSC YKPCCCSSGC GSSCCQSSCC KPCCSQSSCC KPCSCSSGCG SSCCQSSCCK PCCSQSSCCK PCCCSSGCGS SCCQSSCCKP CCSQSSCCVP ICCQCKI //