ID   TAD3L_HUMAN             Reviewed;         432 AA.
AC   O75528; Q9UFS2;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   28-JUL-2009, entry version 70.
DE   RecName: Full=Transcriptional adapter 3-like;
DE            Short=ADA3-like protein;
DE   AltName: Full=ADA3 homolog;
DE            Short=hADA3;
DE   AltName: Full=STAF54;
GN   Name=TADA3L; Synonyms=ADA3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, AND
RP   INTERACTION WITH PCAF; TAF5L; TAF6L; TAF9; TAF10 AND TAF12.
RX   MEDLINE=98337182; PubMed=9674425; DOI=10.1016/S0092-8674(00)81219-2;
RA   Ogryzko V.V., Kotani T., Zhang X., Schiltz R.L., Howard T.,
RA   Yang X.-J., Howard B.H., Qin J., Nakatani Y.;
RT   "Histone-like TAFs within the PCAF histone acetylase complex.";
RL   Cell 94:35-44(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   MEDLINE=21154917; PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA   Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA   Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA   Wambutt R., Korn B., Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and
RT   analysis of 500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Colon mucosa;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Muscle, and Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION IN THE STAGA COMPLEX, SUBCELLULAR LOCATION, AND MASS
RP   SPECTROMETRY.
RX   MEDLINE=21448975; PubMed=11564863;
RX   DOI=10.1128/MCB.21.20.6782-6795.2001;
RA   Martinez E., Palhan V.B., Tjernberg A., Lymar E.S., Gamper A.M.,
RA   Kundu T.K., Chait B.T., Roeder R.G.;
RT   "Human STAGA complex is a chromatin-acetylating transcription
RT   coactivator that interacts with pre-mRNA splicing and DNA damage-
RT   binding factors in vivo.";
RL   Mol. Cell. Biol. 21:6782-6795(2001).
RN   [6]
RP   INTERACTION WITH TP53 AND THE HIGH-RISK HPV ONCOPROTEIN E6.
RX   MEDLINE=22133594; PubMed=12138191;
RX   DOI=10.1128/MCB.22.16.5801-5812.2002;
RA   Kumar A., Zhao Y., Meng G., Zeng M., Srinivasan S., Delmolino L.M.,
RA   Gao Q., Dimri G., Weber G.F., Wazer D.E., Band H., Band V.;
RT   "Human papillomavirus oncoprotein E6 inactivates the transcriptional
RT   coactivator human ADA3.";
RL   Mol. Cell. Biol. 22:5801-5812(2002).
RN   [7]
RP   FUNCTION, AND INTERACTION WITH TP53.
RX   MEDLINE=21564072; PubMed=11707411; DOI=10.1093/emboj/20.22.6404;
RA   Wang T., Kobayashi T., Takimoto R., Denes A.E., Snyder E.L.,
RA   el-Deiry W.S., Brachmann R.K.;
RT   "hADA3 is required for p53 activity.";
RL   EMBO J. 20:6404-6413(2001).
RN   [8]
RP   REVIEW, AND PCAF COMPLEX COMPOSITION.
RX   MEDLINE=98337176; PubMed=9674419; DOI=10.1016/S0092-8674(00)81213-1;
RA   Struhl K., Moqtaderi Z.;
RT   "The TAFs in the HAT.";
RL   Cell 94:1-4(1998).
RN   [9]
RP   IDENTIFICATION IN THE TFTC-HAT COMPLEX.
RX   PubMed=12601814; DOI=10.1002/pmic.200390030;
RA   Cavusoglu N., Brand M., Tora L., van Dorsselaer A.;
RT   "Novel subunits of the TATA binding protein free TAFII-containing
RT   transcription complex identified by matrix-assisted laser
RT   desorption/ionization-time of flight mass spectrometry following one-
RT   dimensional gel electrophoresis.";
RL   Proteomics 3:217-223(2003).
CC   -!- FUNCTION: Functions as a component of the PCAF complex. The PCAF
CC       complex is capable of efficiently acetylating histones in a
CC       nucleosomal context. The PCAF complex could be considered as the
CC       human version of the yeast SAGA complex. Also known as a
CC       coactivator for p53/TP53-dependent transcriptional activation.
CC   -!- SUBUNIT: The PCAF complex is composed of a number of TBP-
CC       associated factors (TAFS), such as TAF5, TAF5L, TAF6, TAF6L, TAF9,
CC       TAF10 and TAF12, PCAF, and also PCAF-associated factors (PAFs),
CC       such as TADA2L/ADA2, TADA3L/ADA3 and SPT3. Interacts directly with
CC       TADA2L and PCAF and also with the high-risk HPV oncoprotein E6.
CC       Component of the STAGA transcription coactivator-HAT complex, at
CC       least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L,
CC       TAD1L, TAF10, TAF12, TRRAP and TAF9. Component of the TFTC-HAT
CC       complex.
CC   -!- INTERACTION:
CC       Q8N2W9:PIAS4; NbExp=1; IntAct=EBI-473249, EBI-473160;
CC       P45974:USP5; NbExp=1; IntAct=EBI-473249, EBI-741277;
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O75528-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O75528-2; Sequence=VSP_009739;
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed.
CC   -!- SIMILARITY: Belongs to the NGG1 family.
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DR   EMBL; AF069733; AAC39903.1; -; mRNA.
DR   EMBL; AL117487; CAB55957.1; -; mRNA.
DR   EMBL; AK000228; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BC009240; AAH09240.1; -; mRNA.
DR   EMBL; BC013433; AAH13433.1; -; mRNA.
DR   IPI; IPI00220486; -.
DR   IPI; IPI00375534; -.
DR   PIR; T17267; T17267.
DR   RefSeq; NP_006345.1; -.
DR   RefSeq; NP_597814.1; -.
DR   UniGene; Hs.386390; -.
DR   IntAct; O75528; 17.
DR   PhosphoSite; O75528; -.
DR   PRIDE; O75528; -.
DR   Ensembl; ENST00000301964; ENSP00000307684; ENSG00000171148; Homo sapiens.
DR   Ensembl; ENST00000343450; ENSP00000343649; ENSG00000171148; Homo sapiens.
DR   GeneID; 10474; -.
DR   KEGG; hsa:10474; -.
DR   UCSC; uc003bsx.1; human.
DR   GeneCards; GC03M009796; -.
DR   HGNC; HGNC:19422; TADA3L.
DR   MIM; 602945; gene.
DR   PharmGKB; PA134910395; -.
DR   HOGENOM; O75528; -.
DR   HOVERGEN; O75528; -.
DR   OMA; O75528; GCPFGPL.
DR   NextBio; 39724; -.
DR   ArrayExpress; O75528; -.
DR   Bgee; O75528; -.
DR   CleanEx; HS_TADA3L; -.
DR   GermOnline; ENSG00000171148; Homo sapiens.
DR   GO; GO:0030914; C:STAGA complex; IDA:UniProtKB.
DR   GO; GO:0033276; C:transcription factor TFTC complex; IDA:UniProtKB.
DR   GO; GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.
DR   GO; GO:0003700; F:transcription factor activity; TAS:ProtInc.
DR   GO; GO:0043966; P:histone H3 acetylation; IDA:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription from RNA polyme...; TAS:ProtInc.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR019340; Histone_AcTrfase_su3.
DR   Pfam; PF10198; Ada3; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Complete proteome; Nucleus;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    432       Transcriptional adapter 3-like.
FT                                /FTId=PRO_0000072416.
FT   COILED       40     69       Potential.
FT   COILED      367    407       Potential.
FT   VAR_SEQ     370    432       Missing (in isoform 2).
FT                                /FTId=VSP_009739.
FT   CONFLICT    168    168       E -> G (in Ref. 3; AK000228).
SQ   SEQUENCE   432 AA;  48902 MW;  C86153CFA83F9226 CRC64;
     MSELKDCPLQ FHDFKSVDHL KVCPRYTAVL ARSEDDGIGI EELDTLQLEL ETLLSSASRR
     LRVLEAETQI LTDWQDKKGD RRFLKLGRDH ELGAPPKHGK PKKQKLEGKA GHGPGPGPGR
     PKSKNLQPKI QEYEFTDDPI DVPRIPKNDA PNRFWASVEP YCADITSEEV RTLEELLKPP
     EDEAEHYKIP PLGKHYSQRW AQEDLLEEQK DGARAAAVAD KKKGLMGPLT ELDTKDVDAL
     LKKSEAQHEQ PEDGCPFGAL TQRLLQALVE ENIISPMEDS PIPDMSGKES GADGASTSPR
     NQNKPFSVPH TKSLESRIKE ELIAQGLLES EDRPAEDSED EVLAELRKRQ AELKALSAHN
     RTKKHDLLRL AKEEVSRQEL RQRVRMADNE VMDAFRKIMA ARQKKRTPTK KEKDQAWKTL
     KERESILKLL DG
//