ID NIPS2_HUMAN Reviewed; 286 AA. AC O75323; O43801; Q53X96; DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 08-MAR-2011, entry version 84. DE RecName: Full=Protein NipSnap homolog 2; DE Short=NipSnap2; DE AltName: Full=Glioblastoma-amplified sequence; GN Name=GBAS; Synonyms=NIPSNAP2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98277458; PubMed=9615231; DOI=10.1006/geno.1998.5239; RA Wang X.-Y., Smith D.I., Liu W., James C.D.; RT "GBAS, a novel gene encoding a protein with tyrosine phosphorylation RT sites and a transmembrane domain, is co-amplified with EGFR."; RL Genomics 49:448-451(1998). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98326305; PubMed=9661659; DOI=10.1016/S0378-1119(98)00098-5; RA Seroussi E., Pan H.Q., Kedra D., Roe B.A., Dumanski J.P.; RT "Characterization of the human NIPSNAP1 gene from 22q12: a member of a RT novel gene family."; RL Gene 212:13-20(1998). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., RA Phelan M., Farmer A.; RT "Cloning of human full-length CDSs in BD Creator(TM) system donor RT vector."; RL Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Colon, and Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RA Colinge J., Superti-Furga G., Bennett K.L.; RL Submitted (OCT-2008) to UniProtKB. RN [8] RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-148, AND MASS SPECTROMETRY. RX PubMed=19608861; DOI=10.1126/science.1175371; RA Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., RA Olsen J.V., Mann M.; RT "Lysine acetylation targets protein complexes and co-regulates major RT cellular functions."; RL Science 325:834-840(2009). CC -!- TISSUE SPECIFICITY: Widely expressed. Most abundant in heart and CC skeletal muscle. CC -!- SIMILARITY: Belongs to the NipSnap family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF029786; AAC29002.1; -; mRNA. DR EMBL; AJ001259; CAA04633.1; -; mRNA. DR EMBL; BT007112; AAP35776.1; -; mRNA. DR EMBL; CR407612; CAG28540.1; -; mRNA. DR EMBL; CH471140; EAX07967.1; -; Genomic_DNA. DR EMBL; BC000732; AAH00732.1; -; mRNA. DR EMBL; BC001837; AAH01837.1; -; mRNA. DR EMBL; BC030821; AAH30821.1; -; mRNA. DR IPI; IPI00016077; -. DR RefSeq; NP_001474.1; NM_001483.1. DR UniGene; Hs.591069; -. DR ProteinModelPortal; O75323; -. DR SMR; O75323; 181-286. DR IntAct; O75323; 9. DR MINT; MINT-5003890; -. DR STRING; O75323; -. DR PhosphoSite; O75323; -. DR UCD-2DPAGE; O75323; -. DR PeptideAtlas; O75323; -. DR PRIDE; O75323; -. DR Ensembl; ENST00000322090; ENSP00000313050; ENSG00000146729. DR GeneID; 2631; -. DR KEGG; hsa:2631; -. DR UCSC; uc003tre.1; human. DR CTD; 2631; -. DR GeneCards; GC07P055999; -. DR HGNC; HGNC:4179; GBAS. DR MIM; 603004; gene. DR neXtProt; NX_O75323; -. DR PharmGKB; PA28593; -. DR eggNOG; prNOG05994; -. DR GeneTree; ENSGT00530000063035; -. DR HOGENOM; HBG444280; -. DR HOVERGEN; HBG052627; -. DR InParanoid; O75323; -. DR OMA; FRQDGNE; -. DR PhylomeDB; O75323; -. DR NextBio; 10372; -. DR ArrayExpress; O75323; -. DR Bgee; O75323; -. DR CleanEx; HS_GBAS; -. DR Genevestigator; O75323; -. DR GermOnline; ENSG00000146729; Homo sapiens. DR GO; GO:0005887; C:integral to plasma membrane; TAS:ProtInc. DR GO; GO:0005624; C:membrane fraction; TAS:ProtInc. DR GO; GO:0005739; C:mitochondrion; ISS:UniProtKB. DR InterPro; IPR011008; Dimeric_a/b-barrel. DR InterPro; IPR012577; NIPSNAP. DR Pfam; PF07978; NIPSNAP; 1. DR SUPFAM; SSF54909; Dimer_A_B_barrel; 2. PE 1: Evidence at protein level; KW Acetylation; Complete proteome. FT CHAIN 1 286 Protein NipSnap homolog 2. FT /FTId=PRO_0000221148. FT MOD_RES 148 148 N6-acetyllysine. FT CONFLICT 9 16 RGAAWAGG -> AEALGRR (in Ref. 2; FT CAA04633). SQ SEQUENCE 286 AA; 33743 MW; 7ED85297E4DC9D08 CRC64; MAARVLRARG AAWAGGLLQR AAPCSLLPRL RTWTSSSNRS REDSWLKSLF VRKVDPRKDA HSNLLAKKET SNLYKLQFHN VKPECLEAYN KICQEVLPKI HEDKHYPCTL VGTWNTWYGE QDQAVHLWRY EGGYPALTEV MNKLRENKEF LEFRKARSDM LLSRKNQLLL EFSFWNEPVP RSGPNIYELR SYQLRPGTMI EWGNYWARAI RFRQDGNEAV GGFFSQIGQL YMVHHLWAYR DLQTREDIRN AAWHKHGWEE LVYYTVPLIQ EMESRIMIPL KTSPLQ //