ID LRP4_HUMAN STANDARD; PRT; 1576 AA. AC O75096; DT 15-JUN-2004 (Rel. 44, Created) DT 15-JUN-2004 (Rel. 44, Last sequence update) DT 15-JUN-2004 (Rel. 44, Last annotation update) DE Low density lipoprotein receptor-related protein 4 (Multiple epidermal DE growth factor-like domains 7) (Fragment). GN LRP4 OR MEGF7 OR KIAA0816. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Brain; RX MEDLINE=98360089; PubMed=9693030; RA Nakayama M., Nakajima D., Nagase T., Nomura N., Seki N., Ohara O.; RT "Identification of high-molecular-weight proteins with multiple EGF- RT like motifs by motif-trap screening."; RL Genomics 51:27-34(1998). RN [2] RP SEQUENCE OF 1390-1576 FROM N.A. RC TISSUE=Muscle; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., RA Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., RA Jones S.J., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: Potential cell surface endocytic receptor, which binds CC and internalizes extracellular ligands for degradation by CC lysosomes. CC -!- SUBCELLULAR LOCATION: Type I membrane protein (Potential). CC -!- SIMILARITY: Belongs to the LDLR family. CC -!- SIMILARITY: Contains 3 EGF-like domains. CC -!- SIMILARITY: Contains at least 1 LDL-receptor class A domain. CC -!- SIMILARITY: Contains at least 19 LDL-receptor class B domains. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB011540; BAA32468.1; -. DR EMBL; BC037360; AAH37360.1; -. DR EMBL; BC041048; AAH41048.1; -. DR HSSP; P00736; 1APQ. DR Genew; HGNC:6696; LRP4. DR MIM; 604270; -. DR GO; GO:0005509; F:calcium ion binding; NAS. DR InterPro; IPR000152; Asx_hydroxyl_S. DR InterPro; IPR001881; EGF_Ca. DR InterPro; IPR006209; EGF_like. DR InterPro; IPR002172; LDL_receptor_A. DR InterPro; IPR000033; Ldl_receptor_rep. DR Pfam; PF00008; EGF; 5. DR Pfam; PF00057; Ldl_recept_a; 1. DR Pfam; PF00058; Ldl_recept_b; 19. DR SMART; SM00179; EGF_CA; 1. DR SMART; SM00135; LY; 20. DR PROSITE; PS00010; ASX_HYDROXYL; 1. DR PROSITE; PS01186; EGF_2; 3. DR PROSITE; PS01187; EGF_CA; 1. KW Receptor; Endocytosis; Transmembrane; EGF-like domain; Repeat. FT NON_TER 1 1 FT DOMAIN <1 1396 Extracellular (Potential). FT TRANSMEM 1397 1417 Potential. FT DOMAIN 1418 1576 Cytoplasmic (Potential). FT DOMAIN <1 22 LDL-receptor class A. FT DOMAIN 25 65 EGF-like 1. FT DOMAIN 66 105 EGF-like 2, calcium-binding (Potential). FT DOMAIN 151 192 LDL-receptor class B 1. FT DOMAIN 194 235 LDL-receptor class B 2. FT DOMAIN 237 279 LDL-receptor class B 3. FT DOMAIN 281 322 LDL-receptor class B 4. FT DOMAIN 324 364 LDL-receptor class B 5. FT DOMAIN 369 408 EGF-like 3. FT DOMAIN 456 497 LDL-receptor class B 6. FT DOMAIN 499 540 LDL-receptor class B 7. FT DOMAIN 542 584 LDL-receptor class B 8. FT DOMAIN 586 627 LDL-receptor class B 9. FT DOMAIN 628 668 LDL-receptor class B 10. FT DOMAIN 764 805 LDL-receptor class B 11. FT DOMAIN 807 848 LDL-receptor class B 12. FT DOMAIN 850 892 LDL-receptor class B 13. FT DOMAIN 894 934 LDL-receptor class B 14. FT DOMAIN 935 976 LDL-receptor class B 15. FT DOMAIN 1068 1109 LDL-receptor class B 16. FT DOMAIN 1111 1152 LDL-receptor class B 17. FT DOMAIN 1154 1196 LDL-receptor class B 18. FT DOMAIN 1198 1243 LDL-receptor class B 19. FT DISULFID 29 40 By similarity. FT DISULFID 36 49 By similarity. FT DISULFID 51 64 By similarity. FT DISULFID 70 80 By similarity. FT DISULFID 76 89 By similarity. FT DISULFID 91 104 By similarity. FT DISULFID 373 384 By similarity. FT DISULFID 380 393 By similarity. FT DISULFID 395 407 By similarity. FT CONFLICT 1533 1533 M -> T (in Ref. 2). SQ SEQUENCE 1576 AA; 175608 MW; FCD12ECE0C02FB78 CRC64; LCNGVNDCGD NSDESPQQNC RPRTGEENCN VNNGGCAQKC QMVRGAVQCT CHTGYRLTED GHTCQDVNEC AEEGYCSQGC TNSEGAFQCW CETGYELRPD RRSCKALGPE PVLLFANRID IRQVLPHRSE YTLLLNNLEN AIALDFHHRR ELVFWSDVTL DRILRANLNG SNVEEVVSTG LESPGGLAVD WVHDKLYWTD SGTSRIEVAN LDGAHRKVLL WQNLEKPRAI ALHPMEGTIY WTDWGNTPRI EASSMDGSGR RIIADTHLFW PNGLTIDYAG RRMYWVDAKH HVIERANLDG SHRKAVISQG LPHPFAITVF EDSLYWTDWH TKSINSANKF TGKNQEIIRN KLHFPMDIHT LHPQRQPAGK NRCGDNNGGC THLCLPSGQN YTCACPTGFR KISSHACAQS LDKFLLFARR MDIRRISFDT EDLSDDVIPL ADVRSAVALD WDSRDDHVYW TDVSTDTISR AKWDGTGQEV VVDTSLESPA GLAIDWVTNK LYWTDAGTDR IEVANTDGSM RTVLIWENLD RPRDIVVEPM GGYMYWTDWG ASPKIERAGM DASGRQVIIS SNLTWPNGLA IDYGSQRLYW ADAGMKTIEF AGLDGSKRKV LIGSQLPHPF GLTLYGERIY WTDWQTKSIQ SADRLTGLDR ETLQENLENL MDIHVFHRRR PPVSTPCAME NGGCSHLCLR SPNPSGFSCT CPTGINLLSD GKTCSPGMNS FLIFARRIDI RMVSLDIPYF ADVVVPINIT MKNTIAVGVD PQEGKVYWSD STLHRISRAN LDGSQHEDII TTGLQTTDGL AVDAIGRKVY WTDTGTNRIE VGNLDGSMRK VLVWQNLDSP RAIVLYHEMG FMYWTDWGEN AKLERSGMDG SDRAVLINNN LGWPNGLTVD KASSQLLWAD AHTERIEAAD LNGANRHTLV SPVQHPYGLT LLDSYIYWTD WQTRSIHRAD KGTGSNVILV RSNLPGLMDM QAVDRAQPLG FNKCGSRNGG CSHLCLPRPS GFSCACPTGI QLKGDGKTCD PSPETYLLFS SRGSIRRISL DTSDHTDVHV PVPELNNVIS LDYDSVDGKV YYTDVFLDVI RRADLNGSNM ETVIGRGLKT TDGLAVDWVA RNLYWTDTGR NTIEASRLDG SCRKVLINNS LDEPRAIAVF PRKGYLFWTD WGHIAKIERA NLDGSERKVL INTDLGWPNG LTLDYDTRRI YWVDAHLDRI ESADLNGKLR QVLVGHVSHP FALTQQDRWI YWTDWQTKSI QRVDKYSGRN KETVLANVEG LMDIIVVSPQ RQTGTNACGV NNGGCTHLCF ARASDFVCAC PDEPDSQPCS LVPGLVPPAP RATGMSEKSP VLPNTPPTTL YSSTTRTRTS LEEVEGRCSE RDARLGLCAR SNDAVPAAPG EGLHISYAIG GLLSILLILV VIAALMLYRH KKSKFTDPGM GNLTYSNPSY RTSTQEVKIE AIPKPAMYNQ LCYKKEGGPD HNYTKEKIKI VEGICLLSGD DAEWDDLKQL RSSRGGLLRD HVCMKTDTVS IQASSGSLDD TEMEQLLQEE QSECSSVHTA ATPERRGSLP DTGWKHERKL SSESQV //