ID CLR1_SCHPO Reviewed; 1238 AA. AC O74808; DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1998, sequence version 1. DT 16-NOV-2011, entry version 64. DE RecName: Full=Cryptic loci regulator protein 1; GN Name=clr1; ORFNames=SPBC2D10.17; OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast). OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; OC Schizosaccharomycetes; Schizosaccharomycetales; OC Schizosaccharomycetaceae; Schizosaccharomyces. OX NCBI_TaxID=284812; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=972 / ATCC 24843; RX MEDLINE=21848401; PubMed=11859360; DOI=10.1038/nature724; RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., RA Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., RA Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., RA Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., RA James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., RA Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., RA Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., RA Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., RA Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., RA Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., RA Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., RA Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., RA Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., RA Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., RA Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., RA Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., RA Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., RA Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., RA Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., RA Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., RA Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., RA Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.; RT "The genome sequence of Schizosaccharomyces pombe."; RL Nature 415:871-880(2002). RN [2] RP FUNCTION. RX PubMed=1644273; RA Thon G., Klar A.J.S.; RT "The clr1 locus regulates the expression of the cryptic mating-type RT loci of fission yeast."; RL Genetics 131:287-296(1992). RN [3] RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. RX PubMed=16823372; DOI=10.1038/nbt1222; RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., RA Yoshida M.; RT "ORFeome cloning and global analysis of protein localization in the RT fission yeast Schizosaccharomyces pombe."; RL Nat. Biotechnol. 24:841-847(2006). RN [4] RP FUNCTION, INTERACTION WITH CLR3, AND SUBCELLULAR LOCATION. RX PubMed=17289569; DOI=10.1016/j.cell.2006.12.035; RA Sugiyama T., Cam H.P., Sugiyama R., Noma K., Zofall M., Kobayashi R., RA Grewal S.I.S.; RT "SHREC, an effector complex for heterochromatic transcriptional RT silencing."; RL Cell 128:491-504(2007). CC -!- FUNCTION: Regulates silencing of the mat2 and mat3 loci. Organizes CC the chromatin structure of the mating-type region where it also CC participates in establishing the 'cold spot' for recombination. CC Required for proper positioning of nucleosomes at heterochromatic CC loci and for transcriptional gene silencing (TGS) function of the CC Snf2/Hdac-containing repressor complex (SHREC). CC -!- SUBUNIT: Interacts with clr3. CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome, CC telomere. Note=Associates with major heterochromatin, centromeres, CC sub-telomeres, rDNA and the mat locus. CC -!- SIMILARITY: Contains 1 C2H2-type zinc finger. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CU329671; CAA21175.1; -; Genomic_DNA. DR PIR; T40120; T40120. DR RefSeq; NP_596236.1; NM_001022156.1. DR ProteinModelPortal; O74808; -. DR STRING; O74808; -. DR EnsemblFungi; SPBC2D10.17.1; SPBC2D10.17.1:pep; SPBC2D10.17. DR GeneID; 2540558; -. DR GenomeReviews; CU329671_GR; clr1. DR KEGG; spo:SPBC2D10.17; -. DR NMPDR; fig|4896.1.peg.2102; -. DR GeneDB_Spombe; SPBC2D10.17; -. DR eggNOG; fuNOG13115; -. DR OrthoDB; EOG4VX5DW; -. DR ArrayExpress; O74808; -. DR GO; GO:0005721; C:centromeric heterochromatin; IDA:GeneDB_Spombe. DR GO; GO:0031934; C:mating-type region heterochromatin; IDA:GeneDB_Spombe. DR GO; GO:0016581; C:NuRD complex; IDA:GeneDB_Spombe. DR GO; GO:0033553; C:rDNA heterochromatin; IDA:GeneDB_Spombe. DR GO; GO:0031933; C:telomeric heterochromatin; IDA:GeneDB_Spombe. DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro. DR GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. DR GO; GO:0030702; P:chromatin silencing at centromere; IMP:GeneDB_Spombe. DR GO; GO:0000183; P:chromatin silencing at rDNA; IMP:GeneDB_Spombe. DR GO; GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:GeneDB_Spombe. DR GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:GeneDB_Spombe. DR InterPro; IPR007087; Znf_C2H2. DR InterPro; IPR015880; Znf_C2H2-like. DR SMART; SM00355; ZnF_C2H2; 3. DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2. DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1. PE 1: Evidence at protein level; KW Centromere; Chromatin regulator; Chromosome; Complete proteome; KW Metal-binding; Nucleus; Reference proteome; Telomere; Zinc; KW Zinc-finger. FT CHAIN 1 1238 Cryptic loci regulator protein 1. FT /FTId=PRO_0000290637. FT ZN_FING 1062 1087 C2H2-type. FT COMPBIAS 198 297 Ser-rich. SQ SEQUENCE 1238 AA; 136677 MW; 5C6F2213478758CC CRC64; MAEPDISSSE TLTELQQLRL LYFFCFYHAA PFNVKTLVHS LIPPGALSYL LSTYDILRPW LMALRVREGP VNDISTIVQL YEEIVKTGFF INPPPFESYS QTLVARITTL GRPKLQVQQE AQSEVYQRAS TNTQQQVSNV SHGNFKPNSS VNTEPNTSIL SNSKYAGIKP FDFQSSSQNP GLVCEQKTFY QHQFRPFSNL PSNKSSPVKH VSPNVKNNSK KTASSVNSNH SSIPSSITKS NISSLDVYGS EKLISSGSQQ PGHGMVQTTS DKVNASASLY DRSPSKKDIT SSRNTSSYNL GSMRNPSTLK NAAHANPFEG LRFQGSSAVL KEGLNSTVKK TFFDNLNSEK VCPSVSPFLT PDNIASSILY STASFSRSKP DRPRLNLSLE LKLMQNELNK GQLKKQFKGD LRNLADWNNL SLVSSKFPSL PITNLRPDGS FLKHRRFNEE IAYNRQTLEK AIKQLDLSPD KVIQLREQNG VAVNGRVCYP TRNKHSEISA QSSSSLGVTK SLASEVYSSS TVDTISKLNT DKDNYLIKSK KEPIQQKSVS SETTLVKPSS TSSYIDTTNN VLKTNSSFKS SGLTSGPRNE KELLPEGIPT SHNNSETQAQ TADVSNIAAS ADGIYNSDQE KPPEKLDVTK RAFGREIENS NEKELLTSTF LSPSAESQVC LAEIKTIRPG LVPKKQFSVD QNNVISDNTD CSLPKPSNSK LSSISSDGDA SSNRMAVPDK SPFVHAAPNS KALTKDSFST HISVSSLLHS DNEISPIDST RKDYFTSKDS NLQTLKEDAS STKQAKDSGT NDFDKLISGN DVSKNNSGEE QSRSALKPLI SGKLSSCESI NLTKDISTVK RKEYFGIEST SSKQPFHDTG SIKIPAKRSF DTIDKDFRSS NIPFADKIKE DGGDKNVISS IHITTELPKS MPVEVPTNAG AQSDQSNVVD SESLNLRENI STSVADVSLS QAGNEAVLSK KACKPLVLID PFEEKVLKAF NMLSKGYAEY RCQWEGCLAN LHSLENFIKH VLLLHHPKSC SVVKCLWASC DMVLPSEEFE MHLRGHLNNI RLNCEVSNCK KCFSNYEDMF KHLQHSHLPF KFTPESFIKI RNGNVKEEAR RTRNAYTQKS GEVECFMETC TPIAKPAPAN WYPVPPPGFN SSLLSRLTQS NQSKDKIIAA LAKRNVYKSF AGLYDSKGKN DNTGYDFDSN YARVGRHGSF ILPVSKSVPT PSLLIEGSIV QRKNIKIE //