ID O71188_9CLOS Unreviewed; 2233 AA. AC O71188; DT 01-AUG-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-2003, sequence version 2. DT 22-JUL-2008, entry version 33. DE SubName: Full=P_protease/methyl transferase/helicase; DE Flags: Fragment; OS Grapevine leafroll-associated virus 3. OC Viruses; ssRNA positive-strand viruses, no DNA stage; Closteroviridae; OC Ampelovirus. OX NCBI_TaxID=55951; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NY1; RX MEDLINE=98264508; PubMed=9603346; RA Ling K.S., Zhu H.Y., Drong R.F., Slightom J.L., McFerson J.R., RA Gonsalves D.; RT "Nucleotide sequence of the 3'-terminal two-thirds of the grapevine RT leafroll-associated virus-3 genome reveals a typical monopartite RT closterovirus."; RL J. Gen. Virol. 79:1299-1307(1998). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=NY1; RA Ling K.-S.; RL Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF037268; AAC40717.3; -; Genomic_RNA. DR RefSeq; NP_813795.3; -. DR GeneID; 1444473; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:InterPro. DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW. DR GO; GO:0003723; F:RNA binding; IEA:InterPro. DR GO; GO:0003724; F:RNA helicase activity; IEA:InterPro. DR GO; GO:0003968; F:RNA-directed RNA polymerase activity; IEA:InterPro. DR GO; GO:0006396; P:RNA processing; IEA:InterPro. DR GO; GO:0019079; P:viral genome replication; IEA:InterPro. DR InterPro; IPR005123; 2OG-FeII_Oase. DR InterPro; IPR002588; MeTrfase_vir. DR InterPro; IPR000606; RNA_helicase1_vir. DR Pfam; PF03171; 2OG-FeII_Oxy; 1. DR Pfam; PF01443; Viral_helicase1; 1. DR Pfam; PF01660; Vmethyltransf; 1. PE 4: Predicted; KW ATP-binding; Helicase; Hydrolase; Nucleotide-binding; Protease; KW Transferase. FT NON_TER 2233 2233 SQ SEQUENCE 2233 AA; 244804 MW; CDDC18B6133FB08C CRC64; MDYIRPLRVF SFPHVNNTLE YVRYNKANGD VGAFLTTMKF IGNVKLSDFT PRCAAMIYIG KLTKGVKRTF VPPPVKGFAR QYAVVSGSVS ALRGDGKKVL MEARTSTSAT SDVSDFDVVF EAVSNALLVV HYHRVVPYAP VKREQPKPAV KQDEQKPKRQ ASHWAVKPTA VGVHVPLPKK QEALEPAQSV PQQSLEEKAA LTFGLFFSKG GGDESDAVIL RKGKLFNRAL NVPIDVKNTF VWAKIWDEAS RRRGYFYVKD RAVKFFPIVR GRATIEDFIV NTAPGCDVAL PRIELWSMRE RAFVCTTKGW CWFNNERLRG EIYRRRCFSS SFSIGFLMHL GFRSLKVIRF AGTNILHMPS LNEERTFGWK GGDVYLPNVP KTAIVAGDRT RLGGEILASV ANALNQEEVY SSVVSSITNR LVLRDQSALL SHLDTKLCDM FSQRDAMIRE KPSHRCDVFL KPREREKLRE LFPELSIQFS DSVRSSHPFA NAMRSCFNGI FSRRCGNVCF FDIGGSFTYH VKAGHVNCHV CNPVLDVKDV KRRINEILFL STAGGDSYVS SDLLTEAASK SVSYCSRESQ NCDSRADAGF MVDVYDISPQ QVAEAMDKKG ALVFDIALMF PVELLYGNGE VYLEELDTLV KREGDYLAYN VGQCGEMYEH SFSNVSGFFT FSYVRTSSGN VFKLEYEGYR CGYHHLTMCR AQKSPGTEVT YRSLVPSFVG KSLVFIPVVA GSSVSFKTIV LDSDFVDRIY SYALNTIGTF ENRTFEYAVG AVRSQKTHVI TGSRVVHSKV DISPDDMWGL VVAVMAQAIK DRAKSIRSYN FIKASEGSLA GVFKLFFQTV GDCFSNAVSV YAKAMVHDNF NVLETLMSMP RAFIRKVPGS VVVTICTSGA SDRLELRGAF DISKETFGRK LKNSRLRVFS RAIVEDSIKV MKAMKTEDGK PLPITEDSVY AFIMGNVSNV HCTRAGLLGG SKATVVSSVS KGLVARGAAT KAFSGITSFF STGSLFYDRG LTEDERLDAL VRTENAINSP VGILETSRVA VSKVVAGTKE FWSEVSLNDF TTFVLRNKVL IGIFVASLGA APIAWKYRRG IAANARRYAG SSYETLSSLS SQAAGGLRGL TSSTVSGGSL VVRRGFSSAV TVTRATVAKR QVPLALLSFS TSYAISGCSM LGIWAHALPR HLMFFFGLGT LLGARASANT WKFGGFSNNW CAVPEVVWRG KSVSSLLLPI TLGVSLIIRG LLNDTIPQLA YVPPVEGRNV YDETLRYYRD FDYDEGAGPS GTQHEAVPGD DNDGSTSSVS SYDVVTNVRD VGISTNGEVT GEEETHSPRS VQYTYVEEEV APSAAVAERQ GDPSGSGTAD AMAFVESVKK GVDDVFHQQS SGETAREVEV DGKGLLPESV VGEAPTQERG RAADGNTAQT AVNEGDREPV QSSLVSSPQA DIPKVTQSEV HAQKEVKQEV PLATVSGATP IVDEKPAPSV TTRGVKIIDK GKAVAHVAEK KQVQVEQPKQ RSLTINEGKA GKQLCMFRTC SCGVQLDVYN EATIATRFSN AFTFVDNLKG RSAVFFSKLG EGYTYNGGSH VSSGWPRALE DILTAIKYPS VFDHCLVQKY KMGGGVPFHA DDEECYPSDN PILTVNLVGK ANFSTKCRKG GKVMVINVAS GDYFLMPCGF QRTHLHSVNS IDEGRISLTF RATRRVFGVG RMLQLAGGVS DEKSPGVPNQ QPQSQGATRT ITPKSGGKAL SEGSGREVKG RSTYSIWCEQ DYVRKCEWLR ADNPVMALEP DYTPMTFEVV KTGTSEDAVV EYLKYLAIGI ERTYRALLMA RNIAVTTAEG VLKVPNQVYE SLPGFHVYKS GTDLIFHSTQ DGLRVRDLPY VLIAEKGIFT KGKDVDAVVA LGDNLFVCDD ILVFHDAINL IGALKVARCG MVGESFKSFE YKCYNAPPGG GKTTTLVDEF VKSPNSTATI TANVGSSEDI NMAVKKRDPN LEGLNSATTV NSRVVNFIVR GMYKRVLVDE VHMMHQGLLQ LGVFATGASE GLFFGDINQI PFINREKVFR MDCAVFVPKK ESVVYTSKSY RCPLDVCYLL SSMTVRGTEK CYPEKVVSGK DKPVVRSLSK RPIGTTDDVA EINADVYLCM TQLEKSDMKR SLKGKGKETP VMTVHEAQGK TFSDVVLFRT KKADDSLFTK QPHILVGLSR HTRSLVYAAL SSKLDDKVGT YISDASPQSV SDALLHTFAP AGC //