ID DIA2_MOUSE STANDARD; PRT; 349 AA. AC O70566; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 01-OCT-2000 (Rel. 40, Last annotation update) DE DIAPHANOUS PROTEIN HOMOLOG 2 (DIAPHANOUS-RELATED FORMIN 2) (DRF2) DE (MDIA3) (FRAGMENT). GN DIAPH2 OR DIAP2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RC STRAIN=BALB/C; RX MEDLINE=98163437; PubMed=9497258; RA Bione S., Sala C., Manzini C., Arrigo G., Zuffardi O., Banfi S., RA Borsani G., Jonveaux P., Philippe C., Zuccotti M., Ballabio A., RA Toniolo D.; RT "A human homologue of the Drosophila melanogaster diaphanous gene is RT disrupted in a patient with premature ovarian failure: evidence for RT conserved function in oogenesis and implications for human RT sterility."; RL Am. J. Hum. Genet. 62:533-541(1998). CC -!- FUNCTION: MAY BE INVOLVED IN OOGENESIS. CC -!- DEVELOPMENTAL STAGE: EXPRESSED IN LIVER, HEART, KIDNEY, OVARY AND CC TESTIS, AT E16, P6 AND P16. CC -!- DOMAIN: DRFS ARE REGULATED BY INTRAMOLECULAR GBD-DAD BINDING WHERE CC RHO-GTP ACTIVATES THE DRFS BY DISRUPTING THE GBD-DAD INTERACTION CC (BY SIMILARITY). CC -!- SIMILARITY: CONTAINS 1 FORMIN HOMOLOGY 2 (FH2) DOMAIN. CC -!- SIMILARITY: CONTAINS 1 DRF AUTOREGULATORY DOMAIN (DAD). CC -!- SIMILARITY: BELONGS TO THE FORMIN HOMOLOGY FAMILY. DIAPHANOUS CC SUBFAMILY. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y15910; CAA75871.1; -. DR MGD; MGI:1858500; Diap2. DR InterPro; IPR003104; FH2. DR Pfam; PF02181; FH2; 1. DR SMART; SM00498; FH2; 1. KW Coiled coil. FT NON_TER 1 1 FT DOMAIN <1 319 FH2. FT DOMAIN 250 301 COILED COIL (POTENTIAL). FT DOMAIN 302 316 DAD. FT DOMAIN 320 323 ARG/LYS-RICH (BASIC). FT DOMAIN 286 289 POLY-LYS. SQ SEQUENCE 349 AA; 40557 MW; B79C15CEE0E4F758 CRC64; RDLPDQNALR ELAQLKSEYD DLCEPEQFGV VMSTVKMLRP RLTSILFKLT FEEHVNNIKP SIIAVTLACE ELKKSESFKR LLELILLVGN YMNSGSRNAQ SLGFKINFLC KIKDTKSADQ KSTLLHFLAE ICDEKYRDIL KFPDELEHVE SAGKVSAQIL KSNLVAMEQS ILHLEKNIKN FPPAESHHDK FVEKMMSFTQ NAREQYDKLS TMHSNMLKLY ESLGEYFIFD PNTVNMEEFF GDLNTFRTLF LEALKENHKR KEMEEKSRRA KLAKEKAEQE KLERQKKKKQ LIDINKEGDE TGVMDNLLEA LQSGAAFRDR RKRIPRNPDN RRPPLERSRS RHNGAMSSK //