ID DIAP2_MOUSE STANDARD; PRT; 1098 AA. AC O70566; Q8C2G8; DT 15-JUL-1999 (Rel. 38, Created) DT 29-MAR-2004 (Rel. 43, Last sequence update) DT 01-FEB-2005 (Rel. 46, Last annotation update) DE Diaphanous protein homolog 2 (Diaphanous-related formin 2) (DRF2) DE (mDia3). GN Name=Diaph2; Synonyms=Diap2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE (ISOFORM 2). RC STRAIN=NOD; TISSUE=Thymus; RX MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266; RA Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S., RA Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H., RA Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T., RA Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J., RA Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W., RA Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S., RA Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S., RA Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J., RA Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D., RA Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L., RA Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A., RA Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H., RA Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G., RA Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S., RA Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M., RA Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K., RA Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M., RA Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C., RA Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L., RA Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N., RA Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K., RA Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S., RA Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I., RA Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A., RA Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J., RA Birney E., Hayashizaki Y.; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [2] RP NUCLEOTIDE SEQUENCE OF 750-1098 (ISOFORM 1). RC STRAIN=BALB/c; RX MEDLINE=98163437; PubMed=9497258; RA Bione S., Sala C., Manzini C., Arrigo G., Zuffardi O., Banfi S., RA Borsani G., Jonveaux P., Philippe C., Zuccotti M., Ballabio A., RA Toniolo D.; RT "A human homologue of the Drosophila melanogaster diaphanous gene is RT disrupted in a patient with premature ovarian failure: evidence for RT conserved function in oogenesis and implications for human RT sterility."; RL Am. J. Hum. Genet. 62:533-541(1998). CC -!- FUNCTION: May be involved in oogenesis. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=O70566-1; Sequence=Displayed; CC Name=2; CC IsoId=O70566-2; Sequence=VSP_009424; CC Note=No experimental confirmation available; CC -!- DEVELOPMENTAL STAGE: Expressed in liver, heart, kidney, ovary and CC testis, at E16, P6 and P16. CC -!- DOMAIN: DRFs are regulated by intramolecular GBD-DAD binding where CC Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction CC (By similarity). CC -!- SIMILARITY: Belongs to the formin homology family. Diaphanous CC subfamily. CC -!- SIMILARITY: Contains 1 DRF autoregulatory (DAD) domain. CC -!- SIMILARITY: Contains 1 formin homology 2 (FH2) domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AK088648; BAC40476.1; -. DR EMBL; Y15910; CAA75871.1; -. DR PIR; PT0605; PT0605. DR MGD; MGI:1858500; Diap2. DR InterPro; IPR010465; Drf_DAD. DR InterPro; IPR010472; Drf_FH3. DR InterPro; IPR010473; Drf_GBD. DR InterPro; IPR003104; FH2. DR Pfam; PF06345; Drf_DAD; 1. DR Pfam; PF02181; FH2; 1. DR SMART; SM00498; FH2; 1. KW Alternative splicing; Coiled coil; Oogenesis; Repeat. FT DOMAIN 78 284 GBD. FT DOMAIN 183 481 FH3. FT DOMAIN 375 416 Coiled coil (Potential). FT DOMAIN 490 539 Coiled coil (Potential). FT DOMAIN 544 620 FH1 (Pro-rich). FT DOMAIN 625 1068 FH2. FT DOMAIN 999 1050 Coiled coil (Potential). FT DOMAIN 1051 1065 DAD. FT DOMAIN 1069 1072 Arg/Lys-rich (basic). FT DOMAIN 1035 1038 Poly-Lys. FT VARSPLIC 1078 1098 DNRRPPLERSRSRHNGAMSSK -> GKTHCSLHSLVICEYS FT ISNPSSIKGKCTFSETYFS (in isoform 2). FT /FTId=VSP_009424. FT CONFLICT 750 751 KY -> RD (in Ref. 2). SQ SEQUENCE 1098 AA; 124871 MW; BB19D49E049EA8CA CRC64; MEELGAAASG AGGGGGGGEE HGGGRSNKRG AGNRAANEEE TRNKPKLRDR ITSFRKSATK REKPVIQHSI DYQTAVVEIP PALIVHDDRS LILSEKEVLD LFEKMMEDMN LNEEKKAPLR KKDFSIKREM VVQYISATSK SIVGSKVLGG LKNSKHEFTL SSQEYVHELR SGISDEKLLN CLESLRVSLT SHPVSWVNNF GYEGLGVLLD VLEKLLDKKQ QENIDKKNQY KVIQCLKAFM NNKFGLQRIL GDERSLLLLA RAIDPKQQNM MTEIVKILSA ICIVGEENIL DKLLGGITAA AELNNRERFS PIVEGLENNE ALHLQVACMQ FINALVTSPY DLDFRIHLRN EFLRCGLKAM LPTLKEIENE GLDIQLRVFE ENKEDDLSEL SHRLNDIRAE MDDINEVYHL LYNMLKDTAA EPYLLSILQH FLLIRNDYYI RPQYYKIIEE CVSQIVLHCS GMDPDFKYRQ RIDFDFTHLL DACVNKAKVE ENEQKAMEFS KKFDEEFTAR QEAQAELQKR DEKIKELETE IQQLRGQGVP SAIPGPPPPP PLPGAGPCPP PPPPPPPPPP LPGVVPPPPP PLPGMPGIPP PPPPPLSGVP PPPPPPGGVF PLLSGPIELP YGMKQKKLYK PDIPMKRINW SKIEPKELSE NCVWLKLKEE KYENADLFAK LALTFPSQMK GQRNTEAAEE NRSGPPKKKV KELRILDTKT AQNLSIFLGS YRMPYEEIKN IILEVNEEML SEALIQNLVK YLPDQNALRE LAQLKSEYDD LCEPEQFGVV MSTVKMLRPR LTSILFKLTF EEHVNNIKPS IIAVTLACEE LKKSESFKRL LELILLVGNY MNSGSRNAQS LGFKINFLCK IKDTKSADQK STLLHFLAEI CDEKYRDILK FPDELEHVES AGKVSAQILK SNLVAMEQSI LHLEKNIKNF PPAESHHDKF VEKMMSFTQN AREQYDKLST MHSNMLKLYE SLGEYFIFDP NTVNMEEFFG DLNTFRTLFL EALKENHKRK EMEEKSRRAK LAKEKAEQEK LERQKKKKQL IDINKEGDET GVMDNLLEAL QSGAAFRDRR KRIPRNPDNR RPPLERSRSR HNGAMSSK //