ID NKGD_RAT STANDARD; PRT; 215 AA. AC O70215; DT 05-JUL-2004 (Rel. 44, Created) DT 05-JUL-2004 (Rel. 44, Last sequence update) DT 25-OCT-2004 (Rel. 45, Last annotation update) DE NKG2-D type II integral membrane protein (NKG2-D activating NK DE receptor) (NK cell receptor D) (Killer cell lectin-like receptor DE subfamily K member 1) (NKR-P2) (NK lectin-like receptor) (NKLLR). GN Name=Klrk1; Synonyms=Nkg2d, Nkrp2; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP SEQUENCE FROM N.A., AND TISSUE SPECIFICITY. RC STRAIN=Fischer 344; TISSUE=Natural killer cells; RX MEDLINE=98281903; PubMed=9620593; RA Berg S.F., Dissen E., Westgaard I.H., Fossum S.; RT "Molecular characterization of rat NKR-P2, a lectin-like receptor RT expressed by NK cells and resting T cells."; RL Int. Immunol. 10:379-385(1998). RN [2] RP TISSUE SPECIFICITY. RX PubMed=15048723; DOI=10.1002/eji.200324793; RA Alli R., Savithri B., Das S., Varalakshmi C., Rangaraj N., Khar A.; RT "Involvement of NKR-P2/NKG2D in DC-mediated killing of tumor targets: RT indicative of a common, innate, target-recognition paradigm?"; RL Eur. J. Immunol. 34:1119-1126(2004). CC -!- FUNCTION: Involved in the immune surveillance exerted by T and B CC lymphocytes. Functions as a natural cytotoxicity receptor to CC stimulate perforin-mediated elimination of ligand-expressing tumor CC cells. Signaling involves calcium influx, culminating in the CC expression of TNF-alpha. CC -!- SUBUNIT: Homodimer. Interacts with DAP10. The interaction with CC DAP10 is required for NKG2D cell surface expression (By CC similarity). CC -!- SUBCELLULAR LOCATION: Type II membrane protein (By similarity). CC -!- TISSUE SPECIFICITY: Expressed by natural killer cells and by CC resting thoracic duct CD4+ and CD8+ T cells, but not by thymocytes CC or other hemopoietic cells. Expressed by DC cells. CC -!- SIMILARITY: Contains 1 C-type lectin family domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF009511; AAC40092.1; -. DR HSSP; O54709; 1HQ8. DR RGD; 3180; Nkrp2. DR InterPro; IPR002353; AntifreezeII. DR InterPro; IPR001304; Lectin_C. DR Pfam; PF00059; Lectin_C; 1. DR SMART; SM00034; CLECT; 1. DR PROSITE; PS00615; C_TYPE_LECTIN_1; FALSE_NEG. DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1. KW Glycoprotein; Lectin; Multigene family; Receptor; Signal-anchor; KW Transmembrane. FT DOMAIN 1 51 Cytoplasmic (Potential). FT TRANSMEM 52 74 Signal-anchor for type II membrane FT protein (Potential). FT DOMAIN 75 215 Extracellular (Potential). FT DOMAIN 105 211 C-type lectin. FT DISULFID 95 104 By similarity. FT DISULFID 98 109 By similarity. FT DISULFID 126 210 By similarity. FT DISULFID 188 202 By similarity. FT CARBOHYD 120 120 N-linked (GlcNAc...) (Potential). FT CARBOHYD 130 130 N-linked (GlcNAc...) (Potential). FT CARBOHYD 162 162 N-linked (GlcNAc...) (Potential). SQ SEQUENCE 215 AA; 24438 MW; B49C0364613031AF CRC64; MSKCHNYDLK PAKWDTSQEH QKQRSALPTS RPGENGIIRR RSSIEELKIS PLFVVRVLVA AMTIRFTVIT LTWLAVFITL LCNKEVSVSS REGYCGPCPN DWICHRNNCY QFFNENKAWN QSQASCLSQN SSLLKIYSKE EQDFLKLVKS YHWMGLVQSP ANGSWQWEDG SSLSPNELTL VKTPSGTCAV YGSSFKAYTE DCSNPNTYIC MKRAV //