ID   SDF1_FELCA              Reviewed;          93 AA.
AC   O62657; Q54AJ3;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   26-JUN-2013, entry version 74.
DE   RecName: Full=Stromal cell-derived factor 1;
DE            Short=SDF-1;
DE   AltName: Full=C-X-C motif chemokine 12;
DE   Flags: Precursor;
GN   Name=CXCL12; Synonyms=SDF1;
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
RC   TISSUE=Thymus;
RX   PubMed=9777331; DOI=10.1046/j.1365-2370.1998.00107.x;
RA   Nishimura Y., Miyazawa T., Ikeda Y., Izumiya Y., Nakamura K.,
RA   Cai J.S., Sato E., Kohmoto M., Mikami T.;
RT   "Molecular cloning and sequencing of feline stromal cell-derived
RT   factor-1 alpha and beta.";
RL   Eur. J. Immunogenet. 25:303-305(1998).
CC   -!- FUNCTION: Chemoattractant active on T-lymphocytes, monocytes, but
CC       not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to
CC       induce a rapid and transient rise in the level of intracellular
CC       calcium ions and chemotaxis. Also binds to another C-X-C chemokine
CC       receptor CXCR7, which activates the beta-arrestin pathway and acts
CC       as a scavenger receptor for SDF-1. Acts as a positive regulator of
CC       monocyte migration and a negative regulator of monocyte adhesion
CC       via the LYN kinase. Stimulates migration of monocytes and T-
CC       lymphocytes through its receptors, CXCR4 and CXCR7, and decreases
CC       monocyte adherence to surfaces coated with ICAM-1, a ligand for
CC       beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2
CC       integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through
CC       LYN kinase. Plays a protective role after myocardial infarction.
CC       Has several critical functions during embryonic development;
CC       required for B-cell lymphopoiesis, myelopoiesis in bone marrow and
CC       heart ventricular septum formation (By similarity).
CC   -!- SUBUNIT: Monomer or homodimer; in equilibrium. Dimer formation is
CC       induced by non acidic pH and the presence of multivalent anions,
CC       and by binding to CXCR4 or heparin. Monomeric form is required for
CC       full chemotactic activity and resistance to ischemia/reperfusion
CC       injury, whereas the dimeric form acts as a partial agonist of
CC       CXCR4, stimulating Ca2+ mobilization but with no chemotactic
CC       activity and instead acts as a selective antagonist that blocks
CC       chemotaxis induced by the monomeric form. Interacts with the N-
CC       terminus of CXCR7 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Beta; Synonyms=SDF-1b;
CC         IsoId=O62657-1; Sequence=Displayed;
CC       Name=Alpha; Synonyms=SDF-1a;
CC         IsoId=O62657-2; Sequence=VSP_001055;
CC   -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC)
CC       family.
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DR   EMBL; AB011965; BAA28601.1; -; mRNA.
DR   EMBL; AB011966; BAA28602.1; -; mRNA.
DR   RefSeq; NP_001009847.1; NM_001009847.1.
DR   ProteinModelPortal; O62657; -.
DR   SMR; O62657; 22-89.
DR   STRING; 9685.ENSFCAP00000007102; -.
DR   Ensembl; ENSFCAT00000007670; ENSFCAP00000007102; ENSFCAG00000007670.
DR   GeneID; 493806; -.
DR   KEGG; fca:493806; -.
DR   CTD; 6387; -.
DR   eggNOG; NOG26489; -.
DR   GeneTree; ENSGT00390000014056; -.
DR   HOVERGEN; HBG107437; -.
DR   KO; K10031; -.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Compara.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0001667; P:ameboidal cell migration; IEA:Compara.
DR   GO; GO:0007420; P:brain development; IEA:Compara.
DR   GO; GO:0070098; P:chemokine-mediated signaling pathway; IEA:Compara.
DR   GO; GO:0007281; P:germ cell development; IEA:Compara.
DR   GO; GO:0008354; P:germ cell migration; IEA:Compara.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0050930; P:induction of positive chemotaxis; IEA:Compara.
DR   GO; GO:0008045; P:motor neuron axon guidance; IEA:Compara.
DR   GO; GO:2000107; P:negative regulation of leukocyte apoptotic process; IEA:Compara.
DR   GO; GO:0001569; P:patterning of blood vessels; IEA:Compara.
DR   GO; GO:0090026; P:positive regulation of monocyte chemotaxis; IEA:Compara.
DR   GO; GO:0042098; P:T cell proliferation; IEA:Compara.
DR   InterPro; IPR001811; Chemokine_IL8-like_dom.
DR   Pfam; PF00048; IL8; 1.
DR   SMART; SM00199; SCY; 1.
DR   SUPFAM; SSF54117; Chemokine_IL8; 1.
DR   PROSITE; PS00471; SMALL_CYTOKINES_CXC; FALSE_NEG.
PE   3: Inferred from homology;
KW   Alternative splicing; Chemotaxis; Complete proteome; Cytokine;
KW   Disulfide bond; Growth factor; Secreted; Signal.
FT   SIGNAL        1     21       Potential.
FT   CHAIN        22     93       Stromal cell-derived factor 1.
FT                                /FTId=PRO_0000005108.
FT   REGION       29     33       Receptor and heparin binding (By
FT                                similarity).
FT   REGION       39     41       Receptor binding (By similarity).
FT   REGION       41     51       Heparin binding (By similarity).
FT   REGION       48     50       Receptor binding (By similarity).
FT   REGION       60     70       Receptor binding (By similarity).
FT   MOTIF        22     23       Receptor activation motif (By
FT                                similarity).
FT   BINDING      62     62       Heparin (By similarity).
FT   BINDING      69     69       Heparin (By similarity).
FT   BINDING      85     85       Heparin (By similarity).
FT   SITE         46     46       Important for dimer formation (By
FT                                similarity).
FT   DISULFID     30     55       By similarity.
FT   DISULFID     32     71       By similarity.
FT   VAR_SEQ      90     93       Missing (in isoform Alpha).
FT                                /FTId=VSP_001055.
SQ   SEQUENCE   93 AA;  10581 MW;  44FC763711E9BE37 CRC64;
     MDAKVVAVLA LVLAALCLSD GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV
     ARLKNNNRQV CIDPKLKWIQ EYLEKALNKR FKM
//