ID SDF1_FELCA Reviewed; 93 AA. AC O62657; Q54AJ3; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 19-JAN-2010, entry version 61. DE RecName: Full=Stromal cell-derived factor 1; DE Short=SDF-1; DE AltName: Full=C-X-C motif chemokine 12; DE Flags: Precursor; GN Name=CXCL12; Synonyms=SDF1; OS Felis catus (Cat) (Felis silvestris catus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; OC Felinae; Felis. OX NCBI_TaxID=9685; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA). RC TISSUE=Thymus; RX MEDLINE=98450506; PubMed=9777331; RX DOI=10.1046/j.1365-2370.1998.00107.x; RA Nishimura Y., Miyazawa T., Ikeda Y., Izumiya Y., Nakamura K., RA Cai J.S., Sato E., Kohmoto M., Mikami T.; RT "Molecular cloning and sequencing of feline stromal cell-derived RT factor-1 alpha and beta."; RL Eur. J. Immunogenet. 25:303-305(1998). CC -!- FUNCTION: Chemoattractant active on T-lymphocytes, monocytes, but CC not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to CC induce a rapid and transient rise in the level of intracellular CC calcium ions and chemotaxis. Acts as a positive regulator of CC monocyte migration and a negative regulator of monocyte adhesion CC via the Lyn kinase. Stimulates migration of monocytes through its CC receptor, CXCR4, and decreases monocyte adherence to surfaces CC coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 CC signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of CC monocytes to ICAM-1 through Lyn kinase (By similarity). CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Beta; Synonyms=SDF-1b; CC IsoId=O62657-1; Sequence=Displayed; CC Name=Alpha; Synonyms=SDF-1a; CC IsoId=O62657-2; Sequence=VSP_001055; CC -!- SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB011965; BAA28601.1; -; mRNA. DR EMBL; AB011966; BAA28602.1; -; mRNA. DR RefSeq; NP_001009847.1; -. DR SMR; O62657; 22-89. DR STRING; O62657; -. DR GeneID; 493806; -. DR CTD; 493806; -. DR eggNOG; maNOG21020; -. DR HOVERGEN; O62657; -. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW. DR GO; GO:0008009; F:chemokine activity; IEA:InterPro. DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW. DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR InterPro; IPR002473; C-X-C/Interlkn_8. DR InterPro; IPR001811; Chemokine_IL8. DR Pfam; PF00048; IL8; 1. DR PRINTS; PR00436; INTERLEUKIN8. DR SMART; SM00199; SCY; 1. DR PROSITE; PS00471; SMALL_CYTOKINES_CXC; FALSE_NEG. PE 3: Inferred from homology; KW Alternative splicing; Chemotaxis; Cytokine; Disulfide bond; KW Growth factor; Secreted; Signal. FT SIGNAL 1 21 Potential. FT CHAIN 22 93 Stromal cell-derived factor 1. FT /FTId=PRO_0000005108. FT DISULFID 30 55 By similarity. FT DISULFID 32 71 By similarity. FT VAR_SEQ 90 93 Missing (in isoform Alpha). FT /FTId=VSP_001055. SQ SEQUENCE 93 AA; 10581 MW; 44FC763711E9BE37 CRC64; MDAKVVAVLA LVLAALCLSD GKPVSLSYRC PCRFFESHVA RANVKHLKIL NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKR FKM //