ID OPSUV_APIME Reviewed; 371 AA. AC O61303; Q2YD68; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 24-NOV-2009, entry version 61. DE RecName: Full=Opsin, ultraviolet-sensitive; DE AltName: Full=UV-sensitive opsin; DE Short=AmUVop; DE Short=BUVOPS; GN Name=UVOP; OS Apis mellifera (Honeybee). OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; OC Apidae; Apis. OX NCBI_TaxID=7460; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Head; RX MEDLINE=98171548; PubMed=9502802; RA Townson S.M., Chang B.S.W., Salcedo E., Chadwell L.V., Pierce N.E., RA Britt S.G.; RT "Honeybee blue- and ultraviolet-sensitive opsins: cloning, RT heterologous expression in Drosophila, and physiological RT characterization."; RL J. Neurosci. 18:2412-2422(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DH4; RA Zhang L., Liu Y., Li B., Adams C., Agbai O. II, Allen C., RA Alsbrooks S., Archer P., Arredondo H., Bandaranaike D., Bangura L., RA Beltran B., Beraducci A., Biswalo K., Blyth P., Buhay C., Burch P., RA Cadoree I., Canada A., Cardenas V., Carter K., Cavazos I., Chacko J., RA Chahrour M., Chavez D., Chen A., Chen G., Chen R., Cheng M.-T., RA Chu J., Clerc K., Cockrell R., Coyle M., Cree A., Curry S., Dai W., RA Davila M.L., Davis C., Davy-Carroll L., De Anda C., Delgado O., RA Denson S., Deramo C., Ding Y., Dinh H., Donlin J., McCauley S., RA Dugan-Rocha S., Dunn A., Durbin K., Dziuda D., Egan A., Escotto M., RA Espinosa V., Fa M., Fernandez S., Fernando P., Flagg N., Forbes L., RA Fowler G.J., Fu Q., Fuh E., Garcia A., Garcia R., Garner T., Gench S., RA Ghose S., Gill R., Gonzalez D., Guevara W., Holder M., Haaland W., RA Haeberlen K., Hall B., Hamid H., Hamilton K., Harbes B., Havlak P., RA Hawes A., Hawkins E., Hayes S., Hernandez J., Hines S., Hitchens M., RA Hogues M., Hollins B., Howell L.T., Hume J., Imo K., Jackson L., RA Jacob L., Jiang H., Johnson B., Johnson R., Kelly S., Keys T., RA Khan Z., King L., Kovar C., Kowis A., Lara F., Lee K., Lee S., RA LeGall F.I., Lemon S., Lewis L., Li Y., Li Z., Linnell M., Liu W., RA Liu Y.-S., Liyanage D., London P., Lopez J., Lorensuhewa L., RA Lozado R., Madu R., Maheshwari M., Mahoney C., Malloy K., Mansouri D., RA Martinez E., Mercadao C., Metzker M., Minja E., Morgan M., Morris S., RA Munidasa M., Nazareth L., Ngo D., Nguyen N., Nott A., Nwaokelemeh O., RA Obregon M., Ochi-Okorie C., Odeh E., Okwuonu G., Okwuonu K., RA Parker D., Pasternak S., Patel B., Patel V., Paul H., Perez A., RA Perez L., Pham T., Primus E., Pu L.-L., Puazo M., Qin X., Quinn A., RA Quiroz J., Rabata D., Rachlin E., Ren Y., Rodriguez F., Rojas A., RA Ruiz S.J., Sana M., Sanders W., Santibanez J., Santos R., Savery G., RA Scherer S., Shen H., Shen Y., Sisson I., Sodergren E., Song X.-Z., RA Sorelle R., Svatek A., Taylor E., Taylor T., Thomas N., Thorn R., RA Thornton R., Trejos Z., Usmani K., Vargo C., Verduzco D., RA Villasana D., Waldron L., Wang Q., Wang S., Warren J., Wei X., RA Wheeler D., Williams G., Williams R., Wright R., Wu J., Yakub S., RA Yan K., Yuan Y., Yu F., Zhang J., Zhou J., Worley K.C., Muzny D., RA Weinstock G., Gibbs R.A.; RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP IDENTIFICATION, AND TISSUE SPECIFICITY. RX PubMed=16291092; DOI=10.1016/j.ibmb.2005.09.001; RA Velarde R.A., Sauer C.D., Walden K.K.O., Fahrbach S.E., RA Robertson H.M.; RT "Pteropsin: a vertebrate-like non-visual opsin expressed in the honey RT bee brain."; RL Insect Biochem. Mol. Biol. 35:1367-1377(2005). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently CC linked to 11-cis-retinal. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=353 nm; CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in the dorsal region of the retina. CC -!- PTM: Phosphorylated on some or all of the serine and threonine CC residues present in the C-terminal region (By similarity). CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC Opsin subfamily. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF004169; AAC13418.1; -; mRNA. DR EMBL; AADG05012830; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BK005513; DAA05738.1; -; Genomic_DNA. DR RefSeq; NP_001011605.1; -. DR UniGene; Ame.1210; -. DR GeneID; 406127; -. DR KEGG; ame:406127; -. DR CTD; 406127; -. DR OMA; GYLTSCT; -. DR OrthoDB; EOG9P8FQX; -. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW. DR GO; GO:0007186; P:G-protein coupled receptor protein signalin...; IEA:UniProtKB-KW. DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW. DR GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW. DR InterPro; IPR000276; 7TM_GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_supfam. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000856; Opsin_RH3/RH4. DR PANTHER; PTHR19264:SF17; Opsin_RH3/RH4; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. PE 1: Evidence at protein level; KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor; KW Retinal protein; Sensory transduction; Transducer; Transmembrane; KW Vision. FT CHAIN 1 371 Opsin, ultraviolet-sensitive. FT /FTId=PRO_0000197639. FT TOPO_DOM 1 52 Extracellular (Potential). FT TRANSMEM 53 73 1 (Potential). FT TOPO_DOM 74 84 Cytoplasmic (Potential). FT TRANSMEM 85 105 2 (Potential). FT TOPO_DOM 106 121 Extracellular (Potential). FT TRANSMEM 122 142 3 (Potential). FT TOPO_DOM 143 161 Cytoplasmic (Potential). FT TRANSMEM 162 182 4 (Potential). FT TOPO_DOM 183 209 Extracellular (Potential). FT TRANSMEM 210 230 5 (Potential). FT TOPO_DOM 231 278 Cytoplasmic (Potential). FT TRANSMEM 279 299 6 (Potential). FT TOPO_DOM 300 302 Extracellular (Potential). FT TRANSMEM 303 323 7 (Potential). FT TOPO_DOM 324 371 Cytoplasmic (Potential). FT MOD_RES 318 318 N6-(retinylidene)lysine (By similarity). FT CARBOHYD 3 3 N-linked (GlcNAc...) (Potential). FT DISULFID 120 197 Potential. SQ SEQUENCE 371 AA; 41458 MW; 9B2BB1FF92762956 CRC64; MSNDSIHWEA RYLPAGPPRL LGWNVPAEEL IHIPEHWLVY PEPNPSLHYL LALLYILFTF LALLGNGLVI WIFCAAKSLR TPSNMFVVNL AICDFFMMIK TPIFIYNSFN TGFALGNLGC QIFAVIGSLT GIGAAITNAA IAYDRYSTIA RPLDGKLSRG QVILFIVLIW TYTIPWALMP VMGVWGRFVP EGFLTSCSFD YLTDTNEIRI FVATIFTFSY CIPMILIIYY YSQIVSHVVN HEKALREQAK KMNVDSLRSN ANTSSQSAEI RIAKAAITIC FLYVLSWTPY GVMSMIGAFG NKALLTPGVT MIPACTCKAV ACLDPYVYAI SHPKYRLELQ KRLPWLELQE KPISDSTSTT TETVNTPPAS S //