ID OPSUV_APIME Reviewed; 371 AA. AC O61303; Q2YD68; DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 26-FEB-2020, entry version 107. DE RecName: Full=Opsin, ultraviolet-sensitive; DE AltName: Full=UV-sensitive opsin; DE Short=AmUVop; DE Short=BUVOPS; GN Name=UVOP; OS Apis mellifera (Honeybee). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae; OC Apis. OX NCBI_TaxID=7460; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Head; RX PubMed=9502802; DOI=10.1523/jneurosci.18-07-02412.1998; RA Townson S.M., Chang B.S.W., Salcedo E., Chadwell L.V., Pierce N.E., RA Britt S.G.; RT "Honeybee blue- and ultraviolet-sensitive opsins: cloning, heterologous RT expression in Drosophila, and physiological characterization."; RL J. Neurosci. 18:2412-2422(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=DH4; RG Honey bee genome project; RA Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D., RA Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S., RA Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J., RA Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R., RA Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N., RA Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J., RA Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G., RA Newsham I., Worley K.C., Muzny D.M., Gibbs R.; RL Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases. RN [3] RP IDENTIFICATION, AND TISSUE SPECIFICITY. RX PubMed=16291092; DOI=10.1016/j.ibmb.2005.09.001; RA Velarde R.A., Sauer C.D., Walden K.K.O., Fahrbach S.E., Robertson H.M.; RT "Pteropsin: a vertebrate-like non-visual opsin expressed in the honey bee RT brain."; RL Insect Biochem. Mol. Biol. 35:1367-1377(2005). CC -!- FUNCTION: Visual pigments are the light-absorbing molecules that CC mediate vision. They consist of an apoprotein, opsin, covalently linked CC to 11-cis-retinal. CC -!- BIOPHYSICOCHEMICAL PROPERTIES: CC Absorption: CC Abs(max)=353 nm; CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Expressed in the dorsal region of the retina. CC {ECO:0000269|PubMed:16291092}. CC -!- PTM: Phosphorylated on some or all of the serine and threonine residues CC present in the C-terminal region. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. Opsin CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF004169; AAC13418.1; -; mRNA. DR EMBL; AADG06009813; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BK005513; DAA05738.1; -; Genomic_DNA. DR RefSeq; NP_001011605.1; NM_001011605.1. DR SMR; O61303; -. DR STRING; 7460.GB51369-PA; -. DR PaxDb; O61303; -. DR EnsemblMetazoa; GB51369-RA; GB51369-PA; GB51369. DR GeneID; 406127; -. DR KEGG; ame:406127; -. DR CTD; 406127; -. DR eggNOG; KOG3656; Eukaryota. DR eggNOG; ENOG410XRW9; LUCA. DR HOGENOM; CLU_009579_3_0_1; -. DR InParanoid; O61303; -. DR KO; K04255; -. DR OMA; YTIPWAL; -. DR OrthoDB; 704940at2759; -. DR PhylomeDB; O61303; -. DR Proteomes; UP000005203; Unplaced. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0009881; F:photoreceptor activity; IDA:CACAO. DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW. DR GO; GO:0018298; P:protein-chromophore linkage; IEA:UniProtKB-KW. DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR001760; Opsin. DR InterPro; IPR000856; Opsin_RH3/RH4. DR InterPro; IPR027430; Retinal_BS. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00238; OPSIN. DR PRINTS; PR00577; OPSINRH3RH4. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. DR PROSITE; PS00238; OPSIN; 1. PE 1: Evidence at protein level; KW Chromophore; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Phosphoprotein; Photoreceptor protein; Receptor; KW Reference proteome; Retinal protein; Sensory transduction; Transducer; KW Transmembrane; Transmembrane helix; Vision. FT CHAIN 1..371 FT /note="Opsin, ultraviolet-sensitive" FT /id="PRO_0000197639" FT TOPO_DOM 1..52 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 53..73 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 74..84 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 85..105 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 106..121 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 122..142 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 143..161 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 162..182 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 183..209 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 210..230 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 231..278 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 279..299 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 300..302 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 303..323 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 324..371 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT MOD_RES 318 FT /note="N6-(retinylidene)lysine" FT /evidence="ECO:0000250" FT CARBOHYD 3 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 120..197 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 371 AA; 41458 MW; 9B2BB1FF92762956 CRC64; MSNDSIHWEA RYLPAGPPRL LGWNVPAEEL IHIPEHWLVY PEPNPSLHYL LALLYILFTF LALLGNGLVI WIFCAAKSLR TPSNMFVVNL AICDFFMMIK TPIFIYNSFN TGFALGNLGC QIFAVIGSLT GIGAAITNAA IAYDRYSTIA RPLDGKLSRG QVILFIVLIW TYTIPWALMP VMGVWGRFVP EGFLTSCSFD YLTDTNEIRI FVATIFTFSY CIPMILIIYY YSQIVSHVVN HEKALREQAK KMNVDSLRSN ANTSSQSAEI RIAKAAITIC FLYVLSWTPY GVMSMIGAFG NKALLTPGVT MIPACTCKAV ACLDPYVYAI SHPKYRLELQ KRLPWLELQE KPISDSTSTT TETVNTPPAS S //