ID SCN2B_HUMAN Reviewed; 215 AA. AC O60939; O75302; Q9UNN3; DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 19-JAN-2010, entry version 92. DE RecName: Full=Sodium channel subunit beta-2; DE Flags: Precursor; GN Name=SCN2B; ORFNames=UNQ326/PRO386; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Brain; RX MEDLINE=97439560; PubMed=9295116; RA Eubanks J., Srinivasan J., Dinulos M.B., Disteche C.M., RA Catterall W.A.; RT "Structure and chromosomal localization of the beta2 subunit of the RT human brain sodium channel."; RL NeuroReport 8:2775-2779(1997). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Brain; RX MEDLINE=99104330; PubMed=9887383; DOI=10.1038/sj.ejhg.5200220; RA Bolino A., Seri M., Caroli F., Eubanks J., Srinivasan J., Mandich P., RA Schenone A., Quattrone A., Romeo G., Catterall W.A., Devoto M.; RT "Exclusion of the SCN2B gene as candidate for CMT4B."; RL Eur. J. Hum. Genet. 6:629-634(1998). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Heart; RA Cruz J.S., Santana L.F., Frederick C.A., Isom L.L., Malhotra J.D., RA Mattei L.N., Kass R.S., Xia J., An R.-H., Lederer W.J.; RT "Whether 'slip-mode conductance' occurs."; RL Science 284:711-711(1999). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Isom L.L., Mattei L.N., Ragsdale D.S.; RT "Primary structure and functional expression of a beta 2 subunit of RT human infant brain sodium channels."; RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX MEDLINE=22887296; PubMed=12975309; DOI=10.1101/gr.1293003; RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., RA Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., RA Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., RA Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., RA Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., RA Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., RA Wood W.I., Godowski P.J., Gray A.M.; RT "The secreted protein discovery initiative (SPDI), a large-scale RT effort to identify novel human secreted and transmembrane proteins: a RT bioinformatics assessment."; RL Genome Res. 13:2265-2270(2003). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Crucial in the assembly, expression, and functional CC modulation of the heterotrimeric complex of the sodium channel. CC The subunit beta-2 causes an increase in the plasma membrane CC surface area and in its folding into microvilli. Interacts with CC TNR may play a crucial role in clustering and regulation of CC activity of sodium channels at nodes of Ranvier (By similarity). CC -!- SUBUNIT: The sodium channel consists of a pore-forming alpha CC subunit, beta-1 and beta-2 subunits. Beta-1 is non-covalently CC associated with alpha, while beta-2 is covalently linked by CC disulfide bonds. Interaction with SCN10A and TNR (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein. CC -!- TISSUE SPECIFICITY: Brain specific. CC -!- SIMILARITY: Contains 1 Ig-like C2-type (immunoglobulin-like) CC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF007783; AAC26013.1; -; mRNA. DR EMBL; AF049498; AAC05274.1; -; mRNA. DR EMBL; AF049497; AAC05208.1; -; Genomic_DNA. DR EMBL; AF049496; AAC05208.1; JOINED; Genomic_DNA. DR EMBL; AF107028; AAD47196.1; -; mRNA. DR EMBL; U87555; AAF21472.1; -; mRNA. DR EMBL; AY358945; AAQ89304.1; -; mRNA. DR EMBL; BC036793; AAH36793.1; -; mRNA. DR IPI; IPI00000087; -. DR RefSeq; NP_004579.1; -. DR UniGene; Hs.129783; -. DR SMR; O60939; 30-147. DR STRING; O60939; -. DR TCDB; 8.A.17.2.1; Na+ channel auxiliary subunit beta1-beta4 (SCA-beta) family. DR PhosphoSite; O60939; -. DR PeptideAtlas; O60939; -. DR PRIDE; O60939; -. DR Ensembl; ENST00000278947; ENSP00000278947; ENSG00000149575; Homo sapiens. DR GeneID; 6327; -. DR KEGG; hsa:6327; -. DR UCSC; uc001psf.1; human. DR CTD; 6327; -. DR GeneCards; GC11M117542; -. DR H-InvDB; HIX0010175; -. DR HGNC; HGNC:10589; SCN2B. DR HPA; HPA012585; -. DR MIM; 601327; gene. DR PharmGKB; PA303; -. DR eggNOG; prNOG17903; -. DR HOGENOM; HBG716687; -. DR HOVERGEN; O60939; -. DR InParanoid; O60939; -. DR OMA; CTFNSCY; -. DR OrthoDB; EOG9T7BNV; -. DR PhylomeDB; O60939; -. DR NextBio; 24558; -. DR PMAP-CutDB; O60939; -. DR ArrayExpress; O60939; -. DR Bgee; O60939; -. DR CleanEx; HS_SCN2B; -. DR Genevestigator; O60939; -. DR GermOnline; ENSG00000149575; Homo sapiens. DR GO; GO:0001518; C:voltage-gated sodium channel complex; TAS:UniProtKB. DR GO; GO:0031402; F:sodium ion binding; IEA:UniProtKB-KW. DR GO; GO:0005248; F:voltage-gated sodium channel activity; TAS:ProtInc. DR GO; GO:0006814; P:sodium ion transport; TAS:ProtInc. DR GO; GO:0007268; P:synaptic transmission; TAS:ProtInc. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR000920; Myelin_P0. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 1. DR Pfam; PF07686; V-set; 1. DR PRINTS; PR00213; MYELINP0. DR SMART; SM00409; IG; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 1: Evidence at protein level; KW Complete proteome; Disulfide bond; Glycoprotein; KW Immunoglobulin domain; Ion transport; Ionic channel; Membrane; KW Polymorphism; Signal; Sodium; Sodium channel; Sodium transport; KW Transmembrane; Transport; Voltage-gated channel. FT SIGNAL 1 29 By similarity. FT CHAIN 30 215 Sodium channel subunit beta-2. FT /FTId=PRO_0000014931. FT TOPO_DOM 30 159 Extracellular (Potential). FT TRANSMEM 160 180 Potential. FT TOPO_DOM 181 215 Cytoplasmic (Potential). FT DOMAIN 32 154 Ig-like C2-type. FT CARBOHYD 42 42 N-linked (GlcNAc...) (Potential). FT CARBOHYD 66 66 N-linked (GlcNAc...) (Potential). FT CARBOHYD 74 74 N-linked (GlcNAc...) (Potential). FT DISULFID 55 127 Potential. FT VARIANT 28 28 R -> W (in dbSNP:rs17121819). FT /FTId=VAR_029131. FT VARIANT 47 47 R -> H (in dbSNP:rs17121818). FT /FTId=VAR_029132. FT CONFLICT 2 2 H -> Q (in Ref. 1; AAC26013). FT CONFLICT 8 8 P -> L (in Ref. 1; AAC26013). FT CONFLICT 15 15 T -> N (in Ref. 1; AAC26013). FT CONFLICT 48 48 L -> Q (in Ref. 1; AAC26013). FT CONFLICT 68 68 T -> S (in Ref. 1; AAC26013). FT CONFLICT 156 156 S -> F (in Ref. 3; AAD47196). FT CONFLICT 178 179 MV -> TA (in Ref. 1; AAC26013). SQ SEQUENCE 215 AA; 24326 MW; 94A30A60A32683F3 CRC64; MHRDAWLPRP AFSLTGLSLF FSLVPPGRSM EVTVPATLNV LNGSDARLPC TFNSCYTVNH KQFSLNWTYQ ECNNCSEEMF LQFRMKIINL KLERFQDRVE FSGNPSKYDV SVMLRNVQPE DEGIYNCYIM NPPDRHRGHG KIHLQVLMEE PPERDSTVAV IVGASVGGFL AVVILVLMVV KCVRRKKEQK LSTDDLKTEE EGKTDGEGNP DDGAK //