ID TRI13_HUMAN Reviewed; 407 AA. AC O60858; B2RB49; Q5UBW0; Q5W0U8; Q5W0U9; Q9BQ47; Q9C021; DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot. DT 19-JUL-2005, sequence version 2. DT 03-NOV-2009, entry version 95. DE RecName: Full=Tripartite motif-containing protein 13; DE AltName: Full=Ret finger protein 2; DE AltName: Full=Putative tumor suppressor RFP2; DE AltName: Full=Leukemia-associated protein 5; DE AltName: Full=B-cell chronic lymphocytic leukemia tumor suppressor Leu5; DE AltName: Full=RING finger protein 77; GN Name=TRIM13; Synonyms=LEU5, RFP2, RNF77; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-355. RC TISSUE=Leukemia; RX MEDLINE=98258969; PubMed=9599022; DOI=10.1016/S0014-5793(98)00357-3; RA Kapanadze B., Kashuba V., Baranova A., Rasool O., van Everdink W.J., RA Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., RA Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., RA Fedorova L., Sulimova G., Zelenin A., Deaven L., Lehrach H., RA Grander D., Buys C., Oscier D., Zabarovsky E.R., Einhorn S., RA Yankovsky N.; RT "A cosmid and cDNA fine physical map of a human chromosome 13q14 RT region frequently lost in B-cell chronic lymphocytic leukemia and RT identification of a new putative tumor suppressor gene, Leu5."; RL FEBS Lett. 426:266-270(1998). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORM RP 1). RX MEDLINE=21164809; PubMed=11264177; DOI=10.1182/blood.V97.7.2098; RA Migliazza A., Bosch F., Komatsu H., Cayanis E., Martinotti S., RA Toniato E., Guccione E., Qu X., Chien M., Murty V.V., Gaidano G., RA Inghirami G., Zhang P., Fischer S., Kalachikov S.M., Russo J., RA Edelman I., Efstratiadis A., Dalla-Favera R.; RT "Nucleotide sequence, transcription map, and mutation analysis of the RT 13q14 chromosomal region deleted in B-cell chronic lymphocytic RT leukemia."; RL Blood 97:2098-2104(2001). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT THR-355. RX MEDLINE=21231161; PubMed=11331580; DOI=10.1093/emboj/20.9.2140; RA Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., RA Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., RA Minucci S., Pelicci P.G., Ballabio A.; RT "The tripartite motif family identifies cell compartments."; RL EMBO J. 20:2140-2151(2001). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RX PubMed=14499696; DOI=10.1016/S0165-4608(03)00126-2; RA van Everdink W.J., Baranova A., Lummen C., Tyazhelova T., Looman M.W., RA Ivanov D., Verlind E., Pestova A., Faber H., van der Veen A.Y., RA Yankovsky N., Vellenga E., Buys C.H.; RT "RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene RT candidates for B-cell chronic lymphocytic leukemia."; RL Cancer Genet. Cytogenet. 146:48-57(2003). RN [5] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND VARIANT RP THR-355. RA Baranova A.V., Sangfelt O., Ivanov D.V., Borodina T.A., RA Yankovsky N.K.; RT "RFP2 putative tumor suppressor gene: genomic organization, multiple RT mRNA isoforms and evaluation as a B-cell chronic lymphocytic leukaemia RT candidate."; RL Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RA Corcoran M.M., Hammarsund M., Grander D., Oscier D., Kapanadze B., RA Einhorn S., Sangfelt O.; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). RA Corcoran M.M., Lerner M., Sangfelt O.; RT "Alternative isoform of candidate tumor suppressor RFP2."; RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases. RN [8] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Brain; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [9] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-355. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [10] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., RA Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., RA Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., RA Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R., RA Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., RA Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., RA Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., RA Venter J.C.; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [11] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Blood, and Lung; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: May act as a tumor suppressor. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; Synonyms=Alpha; CC IsoId=O60858-1; Sequence=Displayed; CC Name=2; Synonyms=Beta; CC IsoId=O60858-2; Sequence=VSP_005746, VSP_005747; CC Name=3; CC IsoId=O60858-3; Sequence=VSP_038142; CC -!- DISEASE: May be involved in B-cell chronic lymphocytic leukemia CC (B-CLL) with a 13q14 region deletion. CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. CC -!- SIMILARITY: Contains 1 B box-type zinc finger. CC -!- SIMILARITY: Contains 1 RING-type zinc finger. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ224819; CAA12136.1; -; mRNA. DR EMBL; AF279660; AAK13059.1; -; Genomic_DNA. DR EMBL; AF220127; AAG53500.1; -; mRNA. DR EMBL; AF220128; AAG53501.1; -; mRNA. DR EMBL; AY191002; AAO38979.1; -; mRNA. DR EMBL; AF241849; AAK51624.1; -; Genomic_DNA. DR EMBL; AF241850; AAF91315.1; -; mRNA. DR EMBL; AY455758; AAR31110.1; -; mRNA. DR EMBL; AY764035; AAV51406.1; -; mRNA. DR EMBL; AK314496; BAG37096.1; -; mRNA. DR EMBL; AL137060; CAC43391.1; -; Genomic_DNA. DR EMBL; AL137060; CAH72825.1; -; Genomic_DNA. DR EMBL; AL137060; CAH72826.1; -; Genomic_DNA. DR EMBL; CH471075; EAX08844.1; -; Genomic_DNA. DR EMBL; CH471075; EAX08845.1; -; Genomic_DNA. DR EMBL; BC003579; AAH03579.1; -; mRNA. DR EMBL; BC063407; AAH63407.1; -; mRNA. DR IPI; IPI00477161; -. DR IPI; IPI00607858; -. DR IPI; IPI00944555; -. DR RefSeq; NP_001007279.1; -. DR RefSeq; NP_005789.2; -. DR RefSeq; NP_434698.1; -. DR RefSeq; NP_998755.1; -. DR UniGene; Hs.436922; -. DR HSSP; P38398; 1JM7. DR STRING; O60858; -. DR PRIDE; O60858; -. DR Ensembl; ENST00000298772; ENSP00000298772; ENSG00000204977; Homo sapiens. DR Ensembl; ENST00000356017; ENSP00000348299; ENSG00000204977; Homo sapiens. DR Ensembl; ENST00000378182; ENSP00000367424; ENSG00000204977; Homo sapiens. DR Ensembl; ENST00000378183; ENSP00000367425; ENSG00000204977; Homo sapiens. DR Ensembl; ENST00000420995; ENSP00000412943; ENSG00000204977; Homo sapiens. DR Ensembl; ENST00000442421; ENSP00000404586; ENSG00000204977; Homo sapiens. DR Ensembl; ENST00000457662; ENSP00000399206; ENSG00000204977; Homo sapiens. DR GeneID; 10206; -. DR KEGG; hsa:10206; -. DR UCSC; uc001vdp.1; human. DR UCSC; uc001vdq.1; human. DR CTD; 10206; -. DR GeneCards; GC13P049472; -. DR HGNC; HGNC:9976; TRIM13. DR HPA; HPA000367; -. DR MIM; 605661; gene. DR HOVERGEN; O60858; -. DR NextBio; 38634; -. DR ArrayExpress; O60858; -. DR Bgee; O60858; -. DR CleanEx; HS_TRIM13; -. DR Genevestigator; O60858; -. DR GermOnline; ENSG00000204977; Homo sapiens. DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB. DR GO; GO:0005515; F:protein binding; IEA:InterPro. DR GO; GO:0004871; F:signal transducer activity; IMP:UniProtKB. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW. DR GO; GO:0009653; P:anatomical structure morphogenesis; TAS:ProtInc. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IMP:UniProtKB. DR InterPro; IPR000315; Znf_B-box. DR InterPro; IPR018957; Znf_C3HC4_RING-type. DR InterPro; IPR001841; Znf_RING. DR InterPro; IPR017907; Znf_RING_CS. DR Pfam; PF00643; zf-B_box; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR SMART; SM00336; BBOX; 1. DR SMART; SM00184; RING; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Coiled coil; Complete proteome; Metal-binding; KW Polymorphism; Tumor suppressor; Zinc; Zinc-finger. FT CHAIN 1 407 Tripartite motif-containing protein 13. FT /FTId=PRO_0000056028. FT ZN_FING 10 58 RING-type. FT ZN_FING 89 131 B box-type. FT COILED 172 200 Potential. FT VAR_SEQ 1 1 M -> MDVM (in isoform 3). FT /FTId=VSP_038142. FT VAR_SEQ 175 175 L -> D (in isoform 2). FT /FTId=VSP_005746. FT VAR_SEQ 176 407 Missing (in isoform 2). FT /FTId=VSP_005747. FT VARIANT 355 355 S -> T (in dbSNP:rs1056543). FT /FTId=VAR_013512. SQ SEQUENCE 407 AA; 46988 MW; 94B624345124AEBF CRC64; MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFSSYLTK TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL //