ID RPF2_HUMAN STANDARD; PRT; 407 AA. AC O60858; Q9BQ47; Q9C021; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 25-JAN-2005 (Rel. 46, Last annotation update) DE Ret finger protein 2 (Leukemia associated protein 5) (B-cell chronic DE lymphocytic leukemia tumor suppressor Leu5) (Putative tumor suppressor DE RFP2) (Tripartite motif protein 13) (RING finger protein 77). GN Name=RFP2; Synonyms=LEU5, RNF77, TRIM13; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RC TISSUE=Leukemia; RX MEDLINE=98258969; PubMed=9599022; DOI=10.1016/S0014-5793(98)00357-3; RA Kapanadze B., Kashuba V., Baranova A., Rasool O., van Everdink W.J., RA Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., RA Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., RA Fedorova L., Sulimova G., Zelenin A., Deaven L., Lehrach H., RA Grander D., Buys C., Oscier D., Zabarovsky E.R., Einhorn S., RA Yankovsky N.; RT "A cosmid and cDNA fine physical map of a human chromosome 13q14 RT region frequently lost in B-cell chronic lymphocytic leukemia and RT identification of a new putative tumor suppressor gene, Leu5."; RL FEBS Lett. 426:266-270(1998). RN [2] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RX MEDLINE=21100862; PubMed=11161783; DOI=10.1006/geno.2000.6386; RA Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., RA Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., RA Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., RA Sangfelt O.; RT "Comparative sequence analysis of a region on human chromosome 13q14, RT frequently deleted in B-cell chronic lymphocytic leukemia, and its RT homologous region on mouse chromosome 14."; RL Genomics 70:327-334(2000). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS ALPHA AND BETA). RX MEDLINE=21231161; PubMed=11331580; DOI=10.1093/emboj/20.9.2140; RA Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., RA Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., RA Minucci S., Pelicci P.G., Ballabio A.; RT "The tripartite motif family identifies cell compartments."; RL EMBO J. 20:2140-2151(2001). RN [4] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RX MEDLINE=21164809; PubMed=11264177; DOI=10.1182/blood.V97.7.2098; RA Migliazza A., Bosch F., Komatsu H., Cayanis E., Martinotti S., RA Toniato E., Guccione E., Qu X., Chien M., Murty V.V., Gaidano G., RA Inghirami G., Zhang P., Fischer S., Kalachikov S.M., Russo J., RA Edelman I., Efstratiadis A., Dalla-Favera R.; RT "Nucleotide sequence, transcription map, and mutation analysis of the RT 13q14 chromosomal region deleted in B-cell chronic lymphocytic RT leukemia."; RL Blood 97:2098-2104(2001). RN [5] RP SEQUENCE FROM N.A. (ISOFORM ALPHA), AND VARIANT SER-355. RX PubMed=14499696; DOI=10.1016/S0165-4608(03)00126-2; RA van Everdink W.J., Baranova A., Lummen C., Tyazhelova T., Looman M.W., RA Ivanov D., Verlind E., Pestova A., Faber H., van der Veen A.Y., RA Yankovsky N., Vellenga E., Buys C.H.; RT "RFP2, c13ORF1, and FAM10A4 are the most likely tumor suppressor gene RT candidates for B-cell chronic lymphocytic leukemia."; RL Cancer Genet. Cytogenet. 146:48-57(2003). RN [6] RP SEQUENCE FROM N.A. (ISOFORM ALPHA), AND VARIANT SER-355. RA Corcoran M.M., Hammarsund M., Grander D., Oscier D., Kapanadze B., RA Einhorn S., Sangfelt O.; RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases. RN [7] RP SEQUENCE FROM N.A. RX PubMed=15057823; DOI=10.1038/nature02379; RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., RA Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., RA Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T., RA Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., RA Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., RA Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., RA Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., RA Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., RA Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., RA Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., RA Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., RA Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., RA Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., RA King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., RA Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., RA Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., RA Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., RA Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., RA Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., RA Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R., RA Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.; RT "The DNA sequence and analysis of human chromosome 13."; RL Nature 428:522-528(2004). RN [8] RP SEQUENCE FROM N.A. (ISOFORM ALPHA), AND VARIANT SER-355. RC TISSUE=Blood, and Lung; RX MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length human RT and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: May act as a tumor suppressor. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Alpha; CC IsoId=O60858-1; Sequence=Displayed; CC Name=Beta; CC IsoId=O60858-2; Sequence=VSP_005746, VSP_005747; CC -!- DISEASE: May be involved in B-cell chronic lymphocytic leukemia CC (B-CLL) with a 13q14 region deletion. CC -!- SIMILARITY: Belongs to the TRIM/RBCC family. CC -!- SIMILARITY: Contains 1 B box-type zinc finger. CC -!- SIMILARITY: Contains 1 RING-type zinc finger. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ224819; CAA12136.1; -. DR EMBL; AF241849; AAK51624.1; -. DR EMBL; AF241850; AAF91315.1; -. DR EMBL; AF220127; AAG53500.1; -. DR EMBL; AF220128; AAG53501.1; -. DR EMBL; AF279660; AAK13059.1; -. DR EMBL; AY191002; AAO38979.1; -. DR EMBL; AY455758; AAR31110.1; -. DR EMBL; AL137060; CAC43391.1; -. DR EMBL; BC003579; AAH03579.1; -. DR EMBL; BC063407; AAH63407.1; -. DR HSSP; P38398; 1JM7. DR Genew; HGNC:9976; RFP2. DR H-InvDB; HIX0011322; -. DR MIM; 605661; -. DR GO; GO:0004871; F:signal transducer activity; IEP. DR GO; GO:0009653; P:morphogenesis; TAS. DR GO; GO:0043123; P:positive regulation of I-kappaB kinase/NF-k...; IEP. DR InterPro; IPR000315; Znf_Bbox. DR InterPro; IPR001841; Znf_ring. DR Pfam; PF00643; zf-B_box; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR PRINTS; PR01406; BBOXZNFINGER. DR SMART; SM00336; BBOX; 1. DR SMART; SM00184; RING; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. KW Alternative splicing; Anti-oncogene; Coiled coil; Metal-binding; KW Polymorphism; Zinc; Zinc-finger. FT ZN_FING 10 58 RING-type. FT ZN_FING 89 131 B box-type. FT DOMAIN 172 200 Coiled coil (Potential). FT VARSPLIC 175 175 L -> D (in isoform Beta). FT /FTId=VSP_005746. FT VARSPLIC 176 407 Missing (in isoform Beta). FT /FTId=VSP_005747. FT VARIANT 355 355 T -> S. FT /FTId=VAR_013512. SQ SEQUENCE 407 AA; 47001 MW; E3B624345474AEBA CRC64; MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFTSYLTK TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL //