ID O60858 PRELIMINARY; PRT; 407 AA. AC O60858; DT 01-AUG-1998 (TrEMBLrel. 07, Created) DT 01-AUG-1998 (TrEMBLrel. 07, Last sequence update) DT 01-MAY-2000 (TrEMBLrel. 13, Last annotation update) DE B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA TUMOR SUPPRESSOR LEU5. GN LEU5 OR CLL2-5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. RN [1] RP SEQUENCE FROM N.A. RC TISSUE=LEUKEMIA; RX MEDLINE; 98258969. RA Kapanadze B., Kashuba V., Baranova A., Rasool O., Van Everdink W., RA Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., RA Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., RA Fedorova L., Sulimova G., Zelenin A., Deaven L., Lehrach H., RA Grander D., Buys C., Oscier D., Zabarovsky E.R., Einhorn S., RA Yankovsky N.; RT "A cosmid and cDNA fine physical map of a human chromosome 13q14 RT region frequently lost in B-cell chronic lymphocytic leukemia and RT identification of a new putative tumor suppressor gene, Leu5."; RL FEBS Lett. 426:266-270(1998). CC -!- FUNCTION: MAY ACT AS A TUMOR SUPPRESSOR. CC -!- DISEASE: MAY BE INVOLVED IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA CC (B-CLL) WITH A 13Q14 REGION DELETION. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ224819; CAA12136.1; -. DR INTERPRO; IPR000315; -. DR INTERPRO; IPR001841; -. DR PFAM; PF00097; zf-C3HC4; 1. DR PROSITE; PS00518; ZINC_FINGER_C3HC4; UNKNOWN_1. DR PROSITE; PS50089; ZF_RING; 1. DR PROSITE; PS50119; ZF_BBOX; 1. KW Anti-oncogene; Zinc-finger; Coiled coil. FT ZN_FING 25 34 C3HC4-TYPE. FT DOMAIN 172 200 COILED COIL (POTENTIAL). SQ SEQUENCE 407 AA; 47001 MW; E3B624345474AEBA CRC64; MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFTSYLTK TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL //