ID RPF2_HUMAN STANDARD; PRT; 407 AA. AC O60858; Q9BQ47; Q9C021; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 10-OCT-2003 (Rel. 42, Last annotation update) DE Ret finger protein 2 (Leukemia associated protein 5) (B-cell chronic DE lymphocytic leukemia tumor suppressor Leu5) (Putative tumor suppressor DE RFP2) (Tripartite motif protein 13). GN RFP2 OR LEU5 OR TRIM13. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RC TISSUE=Leukemia; RX MEDLINE=98258969; PubMed=9599022; RA Kapanadze B., Kashuba V., Baranova A., Rasool O., van Everdink W., RA Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., RA Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., RA Fedorova L., Sulimova G., Zelenin A., Deaven L., Lehrach H., RA Grander D., Buys C., Oscier D., Zabarovsky E.R., Einhorn S., RA Yankovsky N.; RT "A cosmid and cDNA fine physical map of a human chromosome 13q14 RT region frequently lost in B-cell chronic lymphocytic leukemia and RT identification of a new putative tumor suppressor gene, Leu5."; RL FEBS Lett. 426:266-270(1998). RN [2] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RX MEDLINE=21100862; PubMed=11161783; RA Kapanadze B., Makeeva N., Corcoran M., Jareborg N., Hammarsund M., RA Baranova A., Zabarovsky E., Vorontsova O., Merup M., Gahrton G., RA Jansson M., Yankovsky N., Einhorn S., Oscier D., Grander D., RA Sangfelt O.; RT "Comparative sequence analysis of a region on human chromosome 13q14, RT frequently deleted in B-cell chronic lymphocytic leukemia, and its RT homologous region on mouse chromosome 14."; RL Genomics 70:327-334(2000). RN [3] RP SEQUENCE FROM N.A. (ISOFORMS ALPHA AND BETA). RX MEDLINE=21231161; PubMed=11331580; RA Reymond A., Meroni G., Fantozzi A., Merla G., Cairo S., Luzi L., RA Riganelli D., Zanaria E., Messali S., Cainarca S., Guffanti A., RA Minucci S., Pelicci P.G., Ballabio A.; RT "The tripartite motif family identifies cell compartments."; RL EMBO J. 20:2140-2151(2001). RN [4] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RX MEDLINE=21164809; PubMed=11264177; RA Migliazza A., Bosch F., Komatsu H., Cayanis E., Martinotti S., RA Toniato E., Guccione E., Qu X., Chien M., Murty V.V., Gaidano G., RA Inghirami G., Zhang P., Fischer S., Kalachikov S.M., Russo J., RA Edelman I., Efstratiadis A., Dalla-Favera R.; RT "Nucleotide sequence, transcription map, and mutation analysis of the RT 13q14 chromosomal region deleted in B-cell chronic lymphocytic RT leukemia."; RL Blood 97:2098-2104(2001). RN [5] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RA Pearce A.; RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases. RN [6] RP SEQUENCE FROM N.A. (ISOFORM ALPHA). RC TISSUE=Lung; RX MEDLINE=22388257; PubMed=12477932; RA Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., RA Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., RA Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., RA Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., RA Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., RA Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., RA Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., RA Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., RA Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., RA Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., RA Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., RA Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., RA Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., RA Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., RA Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., RA Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E., RA Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.; RT "Generation and initial analysis of more than 15,000 full-length RT human and mouse cDNA sequences."; RL Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002). CC -!- FUNCTION: May act as a tumor suppressor. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Alpha; CC IsoId=O60858-1; Sequence=Displayed; CC Name=Beta; CC IsoId=O60858-2; Sequence=VSP_005746, VSP_005747; CC -!- DISEASE: May be involved in B-cell chronic lymphocytic leukemia CC (B-CLL) with a 13q14 region deletion. CC -!- SIMILARITY: Contains 1 RING-type zinc finger. CC -!- SIMILARITY: Contains 1 B box-type zinc finger. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ224819; CAA12136.1; -. DR EMBL; AF241849; AAK51624.1; -. DR EMBL; AF241850; AAF91315.1; -. DR EMBL; AF220127; AAG53500.1; -. DR EMBL; AF220128; AAG53501.1; -. DR EMBL; AF279660; AAK13059.1; -. DR EMBL; AL137060; CAC43391.1; -. DR EMBL; BC003579; AAH03579.1; -. DR Genew; HGNC:9976; RFP2. DR MIM; 605661; -. DR GO; GO:0009653; P:morphogenesis; TAS. DR InterPro; IPR000315; Znf_Bbox. DR InterPro; IPR001841; Znf_ring. DR Pfam; PF00643; zf-B_box; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR SMART; SM00336; BBOX; 1. DR SMART; SM00184; RING; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. KW Anti-oncogene; Zinc-finger; Coiled coil; Alternative splicing; KW Polymorphism. FT ZN_FING 10 58 RING-type. FT ZN_FING 89 131 B box-type. FT DOMAIN 172 200 Coiled coil (Potential). FT VARSPLIC 175 175 L -> D (in isoform Beta). FT /FTId=VSP_005746. FT VARSPLIC 176 407 Missing (in isoform Beta). FT /FTId=VSP_005747. FT VARIANT 355 355 T -> S. FT /FTId=VAR_013512. SQ SEQUENCE 407 AA; 47001 MW; E3B624345474AEBA CRC64; MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFTSYLTK TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL //