ID LEU5_HUMAN STANDARD; PRT; 407 AA. AC O60858; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 16-OCT-2001 (Rel. 40, Last annotation update) DE Leukemia associated protein 5 (B-cell chronic lymphocytic leukemia DE tumor suppressor Leu5). GN LEU5. OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP SEQUENCE FROM N.A. RC TISSUE=Leukemia; RX MEDLINE=98258969; PubMed=9599022; RA Kapanadze B., Kashuba V., Baranova A., Rasool O., van Everdink W., RA Liu Y., Syomov A., Corcoran M., Poltaraus A., Brodyansky V., RA Syomova N., Kazakov A., Ibbotson R., van den Berg A., Gizatullin R., RA Fedorova L., Sulimova G., Zelenin A., Deaven L., Lehrach H., RA Grander D., Buys C., Oscier D., Zabarovsky E.R., Einhorn S., RA Yankovsky N.; RT "A cosmid and cDNA fine physical map of a human chromosome 13q14 RT region frequently lost in B-cell chronic lymphocytic leukemia and RT identification of a new putative tumor suppressor gene, Leu5."; RL FEBS Lett. 426:266-270(1998). CC -!- FUNCTION: MAY ACT AS A TUMOR SUPPRESSOR. CC -!- DISEASE: MAY BE INVOLVED IN B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA CC (B-CLL) WITH A 13Q14 REGION DELETION. CC -!- SIMILARITY: CONTAINS 1 RING-TYPE ZINC FINGER. CC -!- SIMILARITY: CONTAINS 1 B BOX-TYPE ZINC FINGER. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ224819; CAA12136.1; -. DR InterPro; IPR000315; Znf_bbox. DR InterPro; IPR001841; Znf_ring. DR Pfam; PF00643; zf-B_box; 1. DR Pfam; PF00097; zf-C3HC4; 1. DR SMART; SM00336; BBOX; 1. DR SMART; SM00184; RING; 1. DR PROSITE; PS50119; ZF_BBOX; 1. DR PROSITE; PS00518; ZF_RING_1; 1. DR PROSITE; PS50089; ZF_RING_2; 1. KW Anti-oncogene; Zinc-finger; Coiled coil. FT ZN_FING 10 58 RING-TYPE. FT ZN_FING 89 131 B BOX-TYPE. FT DOMAIN 172 200 COILED COIL (POTENTIAL). SQ SEQUENCE 407 AA; 47001 MW; E3B624345474AEBA CRC64; MELLEEDLTC PICCSLFDDP RVLPCSHNFC KKCLEGILEG SVRNSLWRPA PFKCPTCRKE TSATGINSLQ VNYSLKGIVE KYNKIKISPK MPVCKGHLGQ PLNIFCLTDM QLICGICATR GEHTKHVFCS IEDAYAQERD AFESLFQSFE TWRRGDALSR LDTLETSKRK SLQLLTKDSD KVKEFFEKLQ HTLDQKKNEI LSDFETMKLA VMQAYDPEIN KLNTILQEQR MAFNIAEAFK DVSEPIVFLQ QMQEFREKIK VIKETPLPPS NLPASPLMKN FDTSQWEDIK LVDVDKLSLP QDTGTFISKI PWSFYKLFLL ILLLGLVIVF GPTMFLEWSL FDDLATWKGC LSNFTSYLTK TADFIEQSVF YWEQVTDGFF IFNERFKNFT LVVLNNVAEF VCKYKLL //