ID PLXC1_HUMAN Reviewed; 1568 AA. AC O60486; Q59H25; DT 18-APR-2006, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1998, sequence version 1. DT 13-JUL-2010, entry version 69. DE RecName: Full=Plexin-C1; DE AltName: Full=Virus-encoded semaphorin protein receptor; DE AltName: CD_antigen=CD232; DE Flags: Precursor; GN Name=PLXNC1; Synonyms=VESPR; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], MASS SPECTROMETRY, GLYCOSYLATION, RP INTERACTION WITH VACCINIA VIRUS PROTEIN A39R AND HERPESVIRUS SEMA, AND RP TISSUE SPECIFICITY. RC TISSUE=Foreskin; RX MEDLINE=98246049; PubMed=9586637; DOI=10.1016/S1074-7613(00)80552-X; RA Comeau M.R., Johnson R., DuBose R.F., Petersen M., Gearing P., RA VandenBos T., Park L., Farrah T., Buller R.M., Cohen J.I., RA Strockbine L.D., Rauch C., Spriggs M.K.; RT "A poxvirus-encoded semaphorin induces cytokine production from RT monocytes and binds to a novel cellular semaphorin receptor, VESPR."; RL Immunity 8:473-482(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 358-1568. RC TISSUE=Brain; RA Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., RA Ohara O., Nagase T., Kikuno R.F.; RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases. RN [3] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1466, AND MASS RP SPECTROMETRY. RC TISSUE=Cervix carcinoma; RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026; RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., RA Mann M.; RT "Global, in vivo, and site-specific phosphorylation dynamics in RT signaling networks."; RL Cell 127:635-648(2006). RN [4] RP X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 1198-1305. RG Structural genomics consortium (SGC); RT "Crystal structure of the ubiquitin like domain of PLXNC1."; RL Submitted (DEC-2009) to the PDB data bank. CC -!- FUNCTION: Receptor for vaccinia virus semaphorin A39R and for CC herpesvirus Sema protein. Binding of viral semaphorins triggers CC cellular responses leading to the rearrangement of the CC cytoskeleton and to secretion of IL6 and IL8 (By similarity). CC -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane CC protein (Potential). CC -!- TISSUE SPECIFICITY: Detected in heart, brain, lung, spleen and CC placenta. CC -!- PTM: N-glycosylated. CC -!- SIMILARITY: Belongs to the plexin family. CC -!- SIMILARITY: Contains 1 Sema domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF030339; AAC18823.1; -; mRNA. DR EMBL; AB208934; BAD92171.1; -; mRNA. DR IPI; IPI00024766; -. DR PIR; T09074; T09074. DR RefSeq; NP_005752.1; -. DR UniGene; Hs.584845; -. DR PDB; 3KUZ; X-ray; 2.30 A; A/B=1198-1305. DR PDBsum; 3KUZ; -. DR SMR; O60486; 1192-1307, 1365-1545. DR STRING; O60486; -. DR PhosphoSite; O60486; -. DR PRIDE; O60486; -. DR Ensembl; ENST00000258526; ENSP00000258526; ENSG00000136040; Homo sapiens. DR GeneID; 10154; -. DR KEGG; hsa:10154; -. DR UCSC; uc001tdc.1; human. DR CTD; 10154; -. DR GeneCards; GC12P093066; -. DR H-InvDB; HIX0010887; -. DR HGNC; HGNC:9106; PLXNC1. DR HPA; CAB026155; -. DR MIM; 604259; gene. DR PharmGKB; PA33432; -. DR eggNOG; prNOG11301; -. DR HOGENOM; HBG714508; -. DR HOVERGEN; HBG082153; -. DR InParanoid; O60486; -. DR OMA; ADVCRNI; -. DR OrthoDB; EOG95B421; -. DR PhylomeDB; O60486; -. DR Reactome; REACT_18266; Axon guidance. DR NextBio; 38436; -. DR ArrayExpress; O60486; -. DR Bgee; O60486; -. DR CleanEx; HS_PLXNC1; -. DR Genevestigator; O60486; -. DR GermOnline; ENSG00000136040; Homo sapiens. DR GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. DR GO; GO:0005622; C:intracellular; IEA:InterPro. DR GO; GO:0005886; C:plasma membrane; EXP:Reactome. DR GO; GO:0004872; F:receptor activity; IEA:InterPro. DR GO; GO:0005102; F:receptor binding; TAS:ProtInc. DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc. DR GO; GO:0007275; P:multicellular organismal development; IEA:InterPro. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR InterPro; IPR002909; IPT_TIG_rcpt. DR InterPro; IPR003659; Plexin-like. DR InterPro; IPR016201; Plexin-like_fold. DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom. DR InterPro; IPR002165; Plexin_repeat. DR InterPro; IPR008936; Rho_GTPase_activation_prot. DR InterPro; IPR001627; Semaphorin/CD100_Ag. DR Pfam; PF08337; Plexin_cytopl; 1. DR Pfam; PF01437; PSI; 1. DR Pfam; PF01833; TIG; 2. DR SMART; SM00429; IPT; 2. DR SMART; SM00423; PSI; 2. DR SUPFAM; SSF103575; Plexin-like_fold; 1. DR SUPFAM; SSF48350; Rho_GAP; 1. DR SUPFAM; SSF101912; Sema; 1. DR PROSITE; PS51004; SEMA; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Glycoprotein; Membrane; KW Phosphoprotein; Polymorphism; Signal; Transmembrane. FT SIGNAL 1 34 Potential. FT CHAIN 35 1568 Plexin-C1. FT /FTId=PRO_0000232749. FT TOPO_DOM 35 944 Extracellular (Potential). FT TRANSMEM 945 965 Helical; (Potential). FT TOPO_DOM 966 1568 Cytoplasmic (Potential). FT DOMAIN 35 452 Sema. FT MOD_RES 978 978 Phosphoserine (By similarity). FT MOD_RES 1466 1466 Phosphothreonine. FT CARBOHYD 86 86 N-linked (GlcNAc...) (Potential). FT CARBOHYD 141 141 N-linked (GlcNAc...) (Potential). FT CARBOHYD 149 149 N-linked (GlcNAc...) (Potential). FT CARBOHYD 252 252 N-linked (GlcNAc...) (Potential). FT CARBOHYD 386 386 N-linked (GlcNAc...) (Potential). FT CARBOHYD 407 407 N-linked (GlcNAc...) (Potential). FT CARBOHYD 548 548 N-linked (GlcNAc...) (Potential). FT CARBOHYD 582 582 N-linked (GlcNAc...) (Potential). FT CARBOHYD 653 653 N-linked (GlcNAc...) (Potential). FT CARBOHYD 692 692 N-linked (GlcNAc...) (Potential). FT CARBOHYD 771 771 N-linked (GlcNAc...) (Potential). FT CARBOHYD 796 796 N-linked (GlcNAc...) (Potential). FT CARBOHYD 821 821 N-linked (GlcNAc...) (Potential). FT CARBOHYD 890 890 N-linked (GlcNAc...) (Potential). FT VARIANT 1499 1499 E -> K (in dbSNP:rs11107500). FT /FTId=VAR_050602. FT CONFLICT 671 671 K -> R (in Ref. 2; BAD92171). SQ SEQUENCE 1568 AA; 175742 MW; EA0CE5519BEF925D CRC64; MEVSRRKAPP RPPRPAAPLP LLAYLLALAA PGRGADEPVW RSEQAIGAIA ASQEDGVFVA SGSCLDQLDY SLEHSLSRLY RDQAGNCTEP VSLAPPARPR PGSSFSKLLL PYREGAAGLG GLLLTGWTFD RGACEVRPLG NLSRNSLRNG TEVVSCHPQG STAGVVYRAG RNNRWYLAVA ATYVLPEPET ASRCNPAASD HDTAIALKDT EGRSLATQEL GRLKLCEGAG SLHFVDAFLW NGSIYFPYYP YNYTSGAATG WPSMARIAQS TEVLFQGQAS LDCGHGHPDG RRLLLSSSLV EALDVWAGVF SAAAGEGQER RSPTTTALCL FRMSEIQARA KRVSWDFKTA ESHCKEGDQP ERVQPIASST LIHSDLTSVY GTVVMNRTVL FLGTGDGQLL KVILGENLTS NCPEVIYEIK EETPVFYKLV PDPVKNIYIY LTAGKEVRRI RVANCNKHKS CSECLTATDP HCGWCHSLQR CTFQGDCVHS ENLENWLDIS SGAKKCPKIQ IIRSSKEKTT VTMVGSFSPR HSKCMVKNVD SSRELCQNKS QPNRTCTCSI PTRATYKDVS VVNVMFSFGS WNLSDRFNFT NCSSLKECPA CVETGCAWCK SARRCIHPFT ACDPSDYERN QEQCPVAVEK TSGGGRPKEN KGNRTNQALQ VFYIKSIEPQ KVSTLGKSNV IVTGANFTRA SNITMILKGT STCDKDVIQV SHVLNDTHMK FSLPSSRKEM KDVCIQFDGG NCSSVGSLSY IALPHCSLIF PATTWISGGQ NITMMGRNFD VIDNLIISHE LKGNINVSEY CVATYCGFLA PSLKSSKVRT NVTVKLRVQD TYLDCGTLQY REDPRFTGYR VESEVDTELE VKIQKENDNF NISKKDIEIT LFHGENGQLN CSFENITRNQ DLTTILCKIK GIKTASTIAN SSKKVRVKLG NLELYVEQES VPSTWYFLIV LPVLLVIVIF AAVGVTRHKS KELSRKQSQQ LELLESELRK EIRDGFAELQ MDKLDVVDSF GTVPFLDYKH FALRTFFPES GGFTHIFTED MHNRDANDKN ESLTALDALI CNKSFLVTVI HTLEKQKNFS VKDRCLFASF LTIALQTKLV YLTSILEVLT RDLMEQCSNM QPKLMLRRTE SVVEKLLTNW MSVCLSGFLR ETVGEPFYLL VTTLNQKINK GPVDVITCKA LYTLNEDWLL WQVPEFSTVA LNVVFEKIPE NESADVCRNI SVNVLDCDTI GQAKEKIFQA FLSKNGSPYG LQLNEIGLEL QMGTRQKELL DIDSSSVILE DGITKLNTIG HYEISNGSTI KVFKKIANFT SDVEYSDDHC HLILPDSEAF QDVQGKRHRG KHKFKVKEMY LTKLLSTKVA IHSVLEKLFR SIWSLPNSRA PFAIKYFFDF LDAQAENKKI TDPDVVHIWK TNSLPLRFWV NILKNPQFVF DIKKTPHIDG CLSVIAQAFM DAFSLTEQQL GKEAPTNKLL YAKDIPTYKE EVKSYYKAIR DLPPLSSSEM EEFLTQESKK HENEFNEEVA LTEIYKYIVK YFDEILNKLE RERGLEEAQK QLLHVKVLFD EKKKCKWM //