ID GRIN2_HUMAN Reviewed; 458 AA. AC O60269; Q5SVF0; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 16-MAY-2006, sequence version 2. DT 02-JUN-2021, entry version 140. DE RecName: Full=G protein-regulated inducer of neurite outgrowth 2; DE Short=GRIN2; GN Name=GPRIN2; Synonyms=KIAA0514; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-5; HIS-40; MET-47; RP ARG-91; GLY-104 AND PRO-400. RC TISSUE=Brain; RX PubMed=9628581; DOI=10.1093/dnares/5.1.31; RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., RA Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. IX. The RT complete sequences of 100 new cDNA clones from brain which can code for RT large proteins in vitro."; RL DNA Res. 5:31-39(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-5; HIS-40; MET-47; RP ARG-91; GLY-104; ALA-375 AND PRO-400. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP TISSUE SPECIFICITY, INTERACTION WITH GNAO1 AND GNAZ, AND FUNCTION. RX PubMed=10480904; DOI=10.1074/jbc.274.38.26931; RA Chen L.T., Gilman A.G., Kozasa T.; RT "A candidate target for G protein action in brain."; RL J. Biol. Chem. 274:26931-26938(1999). CC -!- FUNCTION: May be involved in neurite outgrowth. CC {ECO:0000269|PubMed:10480904}. CC -!- SUBUNIT: Interacts with activated forms of GNAO1 and GNAZ. CC {ECO:0000269|PubMed:10480904}. CC -!- INTERACTION: CC O60269; Q13639: HTR4; NbExp=2; IntAct=EBI-740397, EBI-6656425; CC O60269; P31947: SFN; NbExp=2; IntAct=EBI-740397, EBI-476295; CC -!- TISSUE SPECIFICITY: Expressed specifically in the cerebellum. CC {ECO:0000269|PubMed:10480904}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA25440.2; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB011086; BAA25440.2; ALT_INIT; mRNA. DR EMBL; AL645529; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC011672; AAH11672.1; -; mRNA. DR CCDS; CCDS73101.1; -. DR RefSeq; NP_055511.2; NM_014696.3. DR RefSeq; XP_005277723.1; XM_005277666.3. DR RefSeq; XP_011538702.1; XM_011540400.2. DR SMR; O60269; -. DR BioGRID; 115070; 28. DR IntAct; O60269; 10. DR MINT; O60269; -. DR STRING; 9606.ENSP00000363436; -. DR iPTMnet; O60269; -. DR PhosphoSitePlus; O60269; -. DR BioMuta; GPRIN2; -. DR EPD; O60269; -. DR jPOST; O60269; -. DR MassIVE; O60269; -. DR MaxQB; O60269; -. DR PaxDb; O60269; -. DR PeptideAtlas; O60269; -. DR PRIDE; O60269; -. DR ProteomicsDB; 49301; -. DR Antibodypedia; 27207; 117 antibodies. DR DNASU; 9721; -. DR Ensembl; ENST00000374314; ENSP00000363433; ENSG00000204175. DR Ensembl; ENST00000374317; ENSP00000363436; ENSG00000204175. DR GeneID; 9721; -. DR KEGG; hsa:9721; -. DR UCSC; uc057taj.1; human. DR CTD; 9721; -. DR DisGeNET; 9721; -. DR GeneCards; GPRIN2; -. DR HGNC; HGNC:23730; GPRIN2. DR HPA; ENSG00000204175; Tissue enhanced (intestine, lung, skin). DR MIM; 611240; gene. DR neXtProt; NX_O60269; -. DR OpenTargets; ENSG00000204175; -. DR PharmGKB; PA162390192; -. DR VEuPathDB; HostDB:ENSG00000204175.5; -. DR eggNOG; ENOG502SG81; Eukaryota. DR GeneTree; ENSGT00570000079168; -. DR HOGENOM; CLU_038162_0_0_1; -. DR InParanoid; O60269; -. DR OMA; SSTVWQA; -. DR OrthoDB; 612273at2759; -. DR PhylomeDB; O60269; -. DR TreeFam; TF337047; -. DR PathwayCommons; O60269; -. DR BioGRID-ORCS; 9721; 28 hits in 976 CRISPR screens. DR ChiTaRS; GPRIN2; human. DR GeneWiki; GPRIN2; -. DR GenomeRNAi; 9721; -. DR Pharos; O60269; Tbio. DR PRO; PR:O60269; -. DR Proteomes; UP000005640; Chromosome 10. DR RNAct; O60269; protein. DR Bgee; ENSG00000204175; Expressed in muscle tissue and 92 other tissues. DR Genevisible; O60269; HS. DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central. DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central. DR InterPro; IPR026646; GPRIN2-like/GPRIN3. DR InterPro; IPR032745; GRIN_C. DR PANTHER; PTHR15718; PTHR15718; 1. DR Pfam; PF15235; GRIN_C; 1. PE 1: Evidence at protein level; KW Reference proteome. FT CHAIN 1..458 FT /note="G protein-regulated inducer of neurite outgrowth 2" FT /id="PRO_0000050759" FT REGION 1..94 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 118..172 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 17..31 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 41..56 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 120..164 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 5 FT /note="R -> H (in dbSNP:rs3127817)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581" FT /id="VAR_059660" FT VARIANT 39 FT /note="L -> V (in dbSNP:rs4926045)" FT /id="VAR_051017" FT VARIANT 40 FT /note="R -> H (in dbSNP:rs3127818)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581" FT /id="VAR_059661" FT VARIANT 47 FT /note="V -> M (in dbSNP:rs3127819)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581" FT /id="VAR_059662" FT VARIANT 91 FT /note="W -> R (in dbSNP:rs3127820)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581" FT /id="VAR_059663" FT VARIANT 100 FT /note="T -> P (in dbSNP:rs7090312)" FT /id="VAR_061656" FT VARIANT 104 FT /note="S -> G (in dbSNP:rs3127679)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581" FT /id="VAR_051018" FT VARIANT 202 FT /note="G -> W (in dbSNP:rs11204658)" FT /id="VAR_061657" FT VARIANT 233 FT /note="A -> S (in dbSNP:rs11204659)" FT /id="VAR_061658" FT VARIANT 241 FT /note="V -> M (in dbSNP:rs9422022)" FT /id="VAR_061659" FT VARIANT 242 FT /note="R -> G (in dbSNP:rs3127683)" FT /id="VAR_061660" FT VARIANT 328 FT /note="S -> C (in dbSNP:rs4445576)" FT /id="VAR_061661" FT VARIANT 375 FT /note="V -> A (in dbSNP:rs3127822)" FT /evidence="ECO:0000269|PubMed:15489334" FT /id="VAR_061662" FT VARIANT 400 FT /note="L -> P (in dbSNP:rs3127823)" FT /evidence="ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581" FT /id="VAR_059664" FT CONFLICT 241..242 FT /note="VR -> MREVG (in Ref. 1; BAA25440 and 3; AAH11672)" FT /evidence="ECO:0000305" SQ SEQUENCE 458 AA; 47450 MW; D6395C187FAD142D CRC64; MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC GCSGAAPE //