ID GRIN2_HUMAN Reviewed; 458 AA. AC O60269; Q5SVF0; DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot. DT 16-MAY-2006, sequence version 2. DT 04-FEB-2015, entry version 102. DE RecName: Full=G protein-regulated inducer of neurite outgrowth 2; DE Short=GRIN2; GN Name=GPRIN2; Synonyms=KIAA0514; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-5; HIS-40; RP MET-47; ARG-91; GLY-104 AND PRO-400. RC TISSUE=Brain; RX PubMed=9628581; DOI=10.1093/dnares/5.1.31; RA Nagase T., Ishikawa K., Miyajima N., Tanaka A., Kotani H., Nomura N., RA Ohara O.; RT "Prediction of the coding sequences of unidentified human genes. IX. RT The complete sequences of 100 new cDNA clones from brain which can RT code for large proteins in vitro."; RL DNA Res. 5:31-39(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164054; DOI=10.1038/nature02462; RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P., RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., RA Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., RA Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., RA Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., RA Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., RA Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., RA Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., RA Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., RA Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., RA Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., RA Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., RA Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., RA Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., RA Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., RA Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., RA Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., RA Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., RA Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., RA Doucette-Stamm L., Beck S., Smith D.R., Rogers J.; RT "The DNA sequence and comparative analysis of human chromosome 10."; RL Nature 429:375-381(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS HIS-5; HIS-40; RP MET-47; ARG-91; GLY-104; ALA-375 AND PRO-400. RC TISSUE=Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP TISSUE SPECIFICITY, INTERACTION WITH GNAO1 AND GNAZ, AND FUNCTION. RX PubMed=10480904; DOI=10.1074/jbc.274.38.26931; RA Chen L.T., Gilman A.G., Kozasa T.; RT "A candidate target for G protein action in brain."; RL J. Biol. Chem. 274:26931-26938(1999). CC -!- FUNCTION: May be involved in neurite outgrowth. CC {ECO:0000269|PubMed:10480904}. CC -!- SUBUNIT: Interacts with activated forms of GNAO1 and GNAZ. CC {ECO:0000269|PubMed:10480904}. CC -!- INTERACTION: CC P31947:SFN; NbExp=2; IntAct=EBI-740397, EBI-476295; CC -!- TISSUE SPECIFICITY: Expressed specifically in the cerebellum. CC {ECO:0000269|PubMed:10480904}. CC -!- SEQUENCE CAUTION: CC Sequence=BAA25440.2; Type=Erroneous initiation; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB011086; BAA25440.2; ALT_INIT; mRNA. DR EMBL; AL645529; CAI14956.1; -; Genomic_DNA. DR EMBL; BC011672; AAH11672.1; -; mRNA. DR CCDS; CCDS73101.1; -. DR RefSeq; NP_055511.2; NM_014696.3. DR RefSeq; XP_005277723.1; XM_005277666.1. DR UniGene; Hs.523375; -. DR ProteinModelPortal; O60269; -. DR BioGrid; 115070; 13. DR IntAct; O60269; 9. DR MINT; MINT-1439763; -. DR STRING; 9606.ENSP00000363433; -. DR MaxQB; O60269; -. DR PaxDb; O60269; -. DR PRIDE; O60269; -. DR Ensembl; ENST00000374314; ENSP00000363433; ENSG00000204175. DR Ensembl; ENST00000374317; ENSP00000363436; ENSG00000204175. DR GeneID; 9721; -. DR KEGG; hsa:9721; -. DR UCSC; uc001jec.3; human. DR CTD; 9721; -. DR GeneCards; GC10P046993; -. DR H-InvDB; HIX0008795; -. DR HGNC; HGNC:23730; GPRIN2. DR HPA; HPA038129; -. DR MIM; 611240; gene. DR neXtProt; NX_O60269; -. DR PharmGKB; PA162390192; -. DR eggNOG; NOG27312; -. DR GeneTree; ENSGT00570000079168; -. DR HOGENOM; HOG000112814; -. DR InParanoid; O60269; -. DR OMA; CKAVATS; -. DR OrthoDB; EOG7034G5; -. DR PhylomeDB; O60269; -. DR TreeFam; TF337047; -. DR GeneWiki; GPRIN2; -. DR GenomeRNAi; 9721; -. DR NextBio; 36567; -. DR PRO; PR:O60269; -. DR Proteomes; UP000005640; Chromosome 10. DR Bgee; O60269; -. DR CleanEx; HS_GPRIN2; -. DR Genevestigator; O60269; -. DR InterPro; IPR026646; GPRIN2-like/GPRIN3. DR PANTHER; PTHR15718; PTHR15718; 1. PE 1: Evidence at protein level; KW Complete proteome; Polymorphism; Reference proteome. FT CHAIN 1 458 G protein-regulated inducer of neurite FT outgrowth 2. FT /FTId=PRO_0000050759. FT VARIANT 5 5 R -> H (in dbSNP:rs3127817). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581}. FT /FTId=VAR_059660. FT VARIANT 39 39 L -> V (in dbSNP:rs4926045). FT /FTId=VAR_051017. FT VARIANT 40 40 R -> H (in dbSNP:rs3127818). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581}. FT /FTId=VAR_059661. FT VARIANT 47 47 V -> M (in dbSNP:rs3127819). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581}. FT /FTId=VAR_059662. FT VARIANT 91 91 W -> R (in dbSNP:rs3127820). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581}. FT /FTId=VAR_059663. FT VARIANT 100 100 T -> P (in dbSNP:rs7090312). FT /FTId=VAR_061656. FT VARIANT 104 104 S -> G (in dbSNP:rs3127679). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581}. FT /FTId=VAR_051018. FT VARIANT 202 202 G -> W (in dbSNP:rs11204658). FT /FTId=VAR_061657. FT VARIANT 233 233 A -> S (in dbSNP:rs11204659). FT /FTId=VAR_061658. FT VARIANT 241 241 V -> M (in dbSNP:rs9422022). FT /FTId=VAR_061659. FT VARIANT 242 242 R -> G (in dbSNP:rs3127683). FT /FTId=VAR_061660. FT VARIANT 328 328 S -> C (in dbSNP:rs4445576). FT /FTId=VAR_061661. FT VARIANT 375 375 V -> A (in dbSNP:rs3127822). FT {ECO:0000269|PubMed:15489334}. FT /FTId=VAR_061662. FT VARIANT 400 400 L -> P (in dbSNP:rs3127823). FT {ECO:0000269|PubMed:15489334, FT ECO:0000269|PubMed:9628581}. FT /FTId=VAR_059664. FT CONFLICT 241 242 VR -> MREVG (in Ref. 1; BAA25440 and 3; FT AAH11672). {ECO:0000305}. SQ SEQUENCE 458 AA; 47450 MW; D6395C187FAD142D CRC64; MSSSRPEPGP WAPLSPRLQP LSQSSSSLLG EGREQRPELR KTASSTVWQA QLGEASTRPQ APEEEGNPPE SMKPARASGP KARPSAGGHW WSSTVGNVST MGGSDLCRLR APSAAAMQRS HSDLVRSTQM RGHSGARKAS LSCSALGSSP VHRAQLQPGG TSGQGGQAPA GLERDLAPED ETSNSAWMLG ASQLSVPPLD LGDTTAHSSS AQAEPKAAEQ LATTTCHALP PAALLCGMRE VRAGGCCHAL PATGILAFPK LVASVSESGL QAQHGVKIHC RLSGGLPGHS HCCAHLWGPA GLVPEPGSRT KDVWTMTSAN DLAPAEASPL SAQDAGVQAA PVAACKAVAT SPSLEAPAAL HVFPEVTLGS SLEEVPSPVR DVRWDAEGMT WEVYGAAVDL EVLGVAIQKH LEMQFEQLQR APASEDSLSV EGRRGPLRAV MQSLRRPSCC GCSGAAPE //