ID KPRB_HUMAN STANDARD; PRT; 369 AA. AC O60256; DT 28-FEB-2003 (Rel. 41, Created) DT 28-FEB-2003 (Rel. 41, Last sequence update) DT 05-JUL-2004 (Rel. 44, Last annotation update) DE Phosphoribosyl pyrophosphate synthetase-associated protein 2 (PRPP DE synthetase-associated protein 2) (41 kDa phosphoribosypyrophosphate DE synthetase-associated protein) (PAP41). GN Name=PRPSAP2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=98207714; PubMed=9545573; DOI=10.1016/S0167-4781(97)00217-0; RA Katashima R., Iwahana H., Fujimura M., Yamaoka T., Ishizuka T., RA Tatibana M., Itakura M.; RT "Molecular cloning of a human cDNA for the 41-kDa RT phosphoribosylpyrophosphate synthetase-associated protein."; RL Biochim. Biophys. Acta 1396:245-250(1998). CC -!- FUNCTION: Seems to play a negative regulatory role in PRPP CC synthesis. CC -!- SUBUNIT: Binds to PRPS1 and PRPS2. CC -!- TISSUE SPECIFICITY: Ubiquitous. CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase CC family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB007851; BAA25435.1; -. DR HSSP; P14193; 1DKR. DR Genew; HGNC:9467; PRPSAP2. DR MIM; 603762; -. DR GO; GO:0004857; F:enzyme inhibitor activity; TAS. DR GO; GO:0006139; P:nucleobase, nucleoside, nucleotide and nucl...; TAS. DR InterPro; IPR000836; PRtransferase. DR InterPro; IPR005946; RibP_Ppkin. DR Pfam; PF00156; Pribosyltran; 1. DR TIGRFAMs; TIGR01251; ribP_PPkin; 1. KW Nucleotide biosynthesis. SQ SEQUENCE 369 AA; 40926 MW; 12A0E46BD4AC55BF CRC64; MFCVTPPELE TKMNITKGGL VLFSANSNSS CMELSKKIAE RLGVEMGKVQ VYQEPNRETR VQIQESVRGK DVFIIQTVSK DVNTTIMELL IMVYACKTSC AKSIIGVIPY FPYSKQCKMR KRGSIVSKLL ASMMCKAGLT HLITMDLHQK EIQGFFNIPV DNLRASPFLL QYIQEEIPDY RNAVIVAKSP ASAKRAQSFA ERLRLGIAVI HGEAQDAESD LVDGRHSPPM VRSVAAIHPS LEIPMLIPKE KPPITVVGDV GGRIAIIVDD IIDDVDSFLA AAETLKERGA YKIFVMATHG LLSSDAPRRI EESAIDEVVV TNTIPHEVQK LQCPKIKTVD ISMILSEAIR RIHNGESMSY LFRNIGLDD //