ID CBX4_MOUSE Reviewed; 551 AA. AC O55187; DT 24-JAN-2001, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1998, sequence version 1. DT 31-OCT-2006, entry version 40. DE Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (mPc2). GN Name=Cbx4; Synonyms=Pc2; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=98035734; PubMed=9367786; DOI=10.1006/jmbi.1997.1372; RA Alkema M.J., Jacobs J., Voncken J.W., Jenkins N.A., Copeland N.G., RA Satijn D.P.E., Otte A.P., Berns A., van Lohuizen M.; RT "MPc2, a new murine homolog of the Drosophila polycomb protein is a RT member of the mouse polycomb transcriptional repressor complex."; RL J. Mol. Biol. 273:993-1003(1997). CC -!- FUNCTION: Component of the Polycomb group (PcG) multiprotein PRC1 CC complex, a complex required to maintain the transcriptionally CC repressive state of many genes, including Hox genes, throughout CC development. PcG PRC1 complex acts via chromatin remodeling and CC modification of histones; it mediates monoubiquitination of CC histone H2A 'Lys-119', rendering chromatin heritably changed in CC its expressibility. CC -!- SUBUNIT: Component of chromatin-associated class II PcG repressive CC complex 1 (PRC1/hPRC-H) at least composed of PCGF2/RNF110, CC PCGF4/BMI1, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, CC RING1 and RNF2/RING2 (By similarity). CC -!- SUBCELLULAR LOCATION: Nucleus. CC -!- SIMILARITY: Contains 1 chromo domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U63387; AAB96874.1; -; mRNA. DR UniGene; Mm.268070; -. DR HSSP; P05205; 1KNA. DR Ensembl; ENSMUSG00000039989; Mus musculus. DR KEGG; mmu:12418; -. DR MGI; MGI:1195985; Cbx4. DR ArrayExpress; O55187; -. DR InterPro; IPR000953; Chromo. DR Pfam; PF00385; Chromo; 1. DR PRINTS; PR00504; CHROMODOMAIN. DR SMART; SM00298; CHROMO; 1. DR PROSITE; PS00598; CHROMO_1; 1. DR PROSITE; PS50013; CHROMO_2; 1. KW Chromatin regulator; Nuclear protein; Repressor; Transcription; KW Transcription regulation. FT CHAIN 1 551 Chromobox protein homolog 4. FT /FTId=PRO_0000080207. FT DOMAIN 11 69 Chromo. FT COMPBIAS 383 395 Poly-His. SQ SEQUENCE 551 AA; 60582 MW; 30CEB09A82C58400 CRC64; MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR ERQEQLMGYR KRGPKPNPLV VQVPTFARRS NVLTGLQDSS ADNRAKLELG TQGKGQGHQY ELNSKKHHQY QPHSKERSGK PPPARKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA PSPTCPDLGT KSHPPDKWAH GAAAKGYLGA VKPLGGGAGA PGKGSEKGPP NGMTPAPKEA VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEAAEGEAR SPSHKKRAAE ERHPQGDRTF KKAAGASEEK KAEVPCKRRE EEALVSGDAQ PQDLGSRKLS PTKEAFGEQP LQLTTKPDLL AWDPARSSHP PAHHHHHHHH HHHHHTVGLN LSHARKRCLS ETHGEREPCK KRLTARSIST PTCLGGSPVS EHPANVSPTA ASLPQPEVIL LDSDLDEPID LRCVKMRSDA GEPPSTLQVK PEAPAVAAVV APAPASEKPP AEAQEEPVEP LSEFKPFFGN IIITDVTANC LTVTFKEYVT V //