ID CBX4_MOUSE STANDARD; PRT; 551 AA. AC O55187; DT 16-OCT-2001 (Rel. 40, Created) DT 16-OCT-2001 (Rel. 40, Last sequence update) DT 28-FEB-2003 (Rel. 41, Last annotation update) DE Chromobox protein homolog 4 (Polycomb 2 homolog) (Pc2) (MPc2). GN CBX4 OR PC2. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP SEQUENCE FROM N.A. RX MEDLINE=98035734; PubMed=9367786; RA Alkema M.J., Jacobs J., Voncken J.W., Jenkins N.A., Copeland N.G., RA Satijn D.P.E., Otte A.P., Berns A., van Lohuizen M.; RT "MPc2, a new murine homolog of the Drosophila polycomb protein is a RT member of the mouse polycomb transcriptional repressor complex."; RL J. Mol. Biol. 273:993-1003(1997). CC -!- FUNCTION: INVOLVED IN MAINTAINING THE TRANSCRIPTIONALLY REPRESSIVE CC STATE OF GENES. MODIFIES CHROMATIN, RENDERING IT HERITABLY CHANGED CC IN ITS EXPRESSIBILITY. CC -!- SUBUNIT: Component of the chromatin-associated polycomb complex CC (PcG). CC -!- SUBCELLULAR LOCATION: Nuclear. CC -!- SIMILARITY: Contains 1 chromo domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U63387; AAB96874.1; -. DR HSSP; P23197; 1AP0. DR MGD; MGI:1195985; Cbx4. DR InterPro; IPR000953; Chromo. DR Pfam; PF00385; chromo; 1. DR PRINTS; PR00504; CHROMODOMAIN. DR SMART; SM00298; CHROMO; 1. DR PROSITE; PS00598; CHROMO_1; 1. DR PROSITE; PS50013; CHROMO_2; 1. KW Chromatin regulator; Nuclear protein; Transcription regulation; KW Repressor. FT DOMAIN 11 69 CHROMO. FT DOMAIN 383 395 POLY-HIS. SQ SEQUENCE 551 AA; 60581 MW; 30CEB09A82C58400 CRC64; MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR ERQEQLMGYR KRGPKPNPLV VQVPTFARRS NVLTGLQDSS ADNRAKLELG TQGKGQGHQY ELNSKKHHQY QPHSKERSGK PPPARKSGKY YYQLNSKKHH PYQPDPKMYD LQYQGGHKEA PSPTCPDLGT KSHPPDKWAH GAAAKGYLGA VKPLGGGAGA PGKGSEKGPP NGMTPAPKEA VTGNGIGGKM KIVKNKNKNG RIVIVMSKYM ENGMQAVKIK SGEAAEGEAR SPSHKKRAAE ERHPQGDRTF KKAAGASEEK KAEVPCKRRE EEALVSGDAQ PQDLGSRKLS PTKEAFGEQP LQLTTKPDLL AWDPARSSHP PAHHHHHHHH HHHHHTVGLN LSHARKRCLS ETHGEREPCK KRLTARSIST PTCLGGSPVS EHPANVSPTA ASLPQPEVIL LDSDLDEPID LRCVKMRSDA GEPPSTLQVK PEAPAVAAVV APAPASEKPP AEAQEEPVEP LSEFKPFFGN IIITDVTANC LTVTFKEYVT V //