ID O55095_MOUSE Unreviewed; 688 AA. AC O55095; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 08-MAR-2011, entry version 77. DE SubName: Full=Putative uncharacterized protein; DE SubName: Full=SFlt-1; GN Name=Flt1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57b; TISSUE=Lung; RX MEDLINE=98201626; PubMed=9524283; DOI=10.1016/S0378-1119(98)00006-7; RA Kondo K., Hiratsuka S., Subbalakshmi E., Matsushime H., Shibuya M.; RT "Genomic organization of the flt-1 gene encoding for vascular RT endothelial growth factor (VEGF) receptor-1 suggests an intimate RT evolutionary relationship between the 7-Ig and the 5-Ig tyrosine RT kinase receptors."; RL Gene 208:297-305(1998). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57b; TISSUE=Lung; RX MEDLINE=93330572; PubMed=8393164; RA Finnerty H., Kelleher K., Morris G.E., Bean K., Merberg D.M., Kriz R., RA Morris J.C., Sookdeo H., Turner K.J., Wood C.R.; RT "Molecular cloning of murine FLT and FLT4."; RL Oncogene 8:2293-2298(1993). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57b; TISSUE=Lung; RA Kendall R.L., Thomas K.; RT "Inhibition of vascular endothelial cell growth factor activity by an RT endogenously encoded soluble receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993). RN [4] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RX MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9; RA Carninci P., Hayashizaki Y.; RT "High-efficiency full-length cDNA cloning."; RL Methods Enzymol. 303:19-44(1999). RN [5] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RX PubMed=16141073; DOI=10.1126/science.1112009; RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium; RT "Antisense Transcription in the Mammalian Transcriptome."; RL Science 309:1564-1566(2005). RN [6] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team; RT "Analysis of the mouse transcriptome based on functional annotation of RT 60,770 full-length cDNAs."; RL Nature 420:563-573(2002). RN [7] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RG The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group); RT "The Transcriptional Landscape of the Mammalian Genome."; RL Science 309:1559-1563(2005). RN [8] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium; RT "Functional annotation of a full-length mouse cDNA collection."; RL Nature 409:685-690(2001). RN [9] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RX MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100; RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.; RT "Normalization and subtraction of cap-trapper-selected cDNAs to RT prepare full-length cDNA libraries for rapid discovery of new genes."; RL Genome Res. 10:1617-1630(2000). RN [10] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RX MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600; RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., RA Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., RA Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., RA Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., RA Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., RA Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.; RT "RIKEN integrated sequence analysis (RISA) system--384-format RT sequencing pipeline with 384 multicapillary sequencer."; RL Genome Res. 10:1757-1771(2000). RN [11] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57BL/6J; TISSUE=Amnion; RA Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K., RA Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S., RA Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N., RA Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D., RA Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A., RA Muramatsu M., Hayashizaki Y.; RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D88690; BAA24499.1; -; mRNA. DR EMBL; AK146906; BAE27519.1; -; mRNA. DR IPI; IPI00551339; -. DR UniGene; Mm.389712; -. DR HSSP; P17948; 1QSV. DR ProteinModelPortal; O55095; -. DR SMR; O55095; 130-230. DR STRING; O55095; -. DR Ensembl; ENSMUST00000110529; ENSMUSP00000106158; ENSMUSG00000029648. DR UCSC; uc009aoi.1; mouse. DR MGI; MGI:95558; Flt1. DR HOVERGEN; HBG053003; -. DR ArrayExpress; O55095; -. DR Bgee; O55095; -. DR Genevestigator; O55095; -. DR GO; GO:0005887; C:integral to plasma membrane; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0042802; F:identical protein binding; IPI:MGI. DR GO; GO:0005021; F:vascular endothelial growth factor receptor activity; IDA:MGI. DR GO; GO:0016477; P:cell migration; IGI:MGI. DR GO; GO:0001569; P:patterning of blood vessels; IMP:MGI. DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro. DR GO; GO:0002040; P:sprouting angiogenesis; IMP:MGI. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR009135; Tyr_prot_kinase_VEGFR1_rcpt_N. DR InterPro; IPR009134; Tyr_prot_kinase_VEGFR_rcpt_N. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 6. DR Pfam; PF07679; I-set; 2. DR Pfam; PF07686; V-set; 1. DR PRINTS; PR01832; VEGFRECEPTOR. DR PRINTS; PR01833; VEGFRECEPTR1. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 1. DR PROSITE; PS50835; IG_LIKE; 4. PE 2: Evidence at transcript level; SQ SEQUENCE 688 AA; 77522 MW; 0301825F7F961A99 CRC64; MVSCWDTAVL PYALLGCLLL TGYGSGSKLK VPELSLKGTQ HVMQAGQTLF LKCRGEAAHS WSLPTTVSQE DKRLSITPPS ACGRDNRQFC STLTLDTAQA NHTGLYTCRY LPTSTSKKKK AESSIYIFVS DAGSPFIEMH TDIPKLVHMT EGRQLIIPCR VTSPNVTVTL KKFPFDTLTP DGQRITWDSR RGFIIANATY KEIGLLNCEA TVNGHLYQTN YLTHRQTNTI LDVQIRPPSP VRLLHGQTLV LNCTATTELN TRVQMSWNYP GKATKRASIR QRIDRSHSHN NVFHSVLKIN NVESRDKGLY TCRVKSGSSF QSFNTSVHVY EKGFISVKHR KQPVQETTAG RRSYRLSMKV KAFPSPEIVW LKDGSPATLK SARYLVHGYS LIIKDVTTED AGDYTILLGI KQSRLFKNLT ATLIVNVKPQ IYEKSVSSLP SPPLYPLGSR QVLTCTVYGI PRPTITWLWH PCHHNHSKER YDFCTENEES FILDPSSNLG NRIESISQRM TVIEGTNKTV STLVVADSQT PGIYSCRAFN KIGTVERNIK FYVTDVPNGF HVSLEKMPAE GEDLKLSCVV NKFLYRDITW ILLRTVNNRT MHHSISKQKM ATTQDYSITL NLVIKNVSLE DSGTYACRAR NIYTGEDILR KTEVLVRGEH CGKKAIFSRI SKFKSRRNDC TTQSHVKH //