ID O55095_MOUSE Unreviewed; 688 AA. AC O55095; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 10-AUG-2010, entry version 72. DE SubName: Full=Putative uncharacterized protein; DE SubName: Full=SFlt-1; GN Name=Flt1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57b; TISSUE=Lung; RX MEDLINE=98201626; PubMed=9524283; DOI=10.1016/S0378-1119(98)00006-7; RA Kondo K., Hiratsuka S., Subbalakshmi E., Matsushime H., Shibuya M.; RT "Genomic organization of the flt-1 gene encoding for vascular RT endothelial growth factor (VEGF) receptor-1 suggests an intimate RT evolutionary relationship between the 7-Ig and the 5-Ig tyrosine RT kinase receptors."; RL Gene 208:297-305(1998). RN [2] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57b; TISSUE=Lung; RX MEDLINE=93330572; PubMed=8393164; RA Finnerty H., Kelleher K., Morris G.E., Bean K., Merberg D.M., Kriz R., RA Morris J.C., Sookdeo H., Turner K.J., Wood C.R.; RT "Molecular cloning of murine FLT and FLT4."; RL Oncogene 8:2293-2298(1993). RN [3] RP NUCLEOTIDE SEQUENCE. RC STRAIN=C57b; TISSUE=Lung; RA Kendall R.L., Thomas K.; RT "Inhibition of vascular endothelial cell growth factor activity by an RT endogenously encoded soluble receptor."; RL Proc. Natl. Acad. Sci. U.S.A. 90:10705-10709(1993). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=C57BL/6J; TISSUE=Amnion; RX PubMed=16141072; DOI=10.1126/science.1112014; RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E., RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., RA Hayashizaki Y.; RT "The transcriptional landscape of the mammalian genome."; RL Science 309:1559-1563(2005). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; D88690; BAA24499.1; -; mRNA. DR EMBL; AK146906; BAE27519.1; -; mRNA. DR IPI; IPI00551339; -. DR UniGene; Mm.389712; -. DR HSSP; P17948; 1QSV. DR ProteinModelPortal; O55095; -. DR SMR; O55095; 32-551, 134-643. DR STRING; O55095; -. DR Ensembl; ENSMUST00000110529; ENSMUSP00000106158; ENSMUSG00000029648; Mus musculus. DR UCSC; uc009aoi.1; mouse. DR MGI; MGI:95558; Flt1. DR HOVERGEN; HBG053003; -. DR ArrayExpress; O55095; -. DR Bgee; O55095; -. DR Genevestigator; O55095; -. DR GO; GO:0005887; C:integral to plasma membrane; IEA:InterPro. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0019838; F:growth factor binding; IEA:InterPro. DR GO; GO:0042802; F:identical protein binding; IPI:MGI. DR GO; GO:0005021; F:vascular endothelial growth factor receptor...; IDA:MGI. DR GO; GO:0016477; P:cell migration; IGI:MGI. DR GO; GO:0001569; P:patterning of blood vessels; IMP:MGI. DR GO; GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:InterPro. DR GO; GO:0002040; P:sprouting angiogenesis; IMP:MGI. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR013098; Ig_I-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003598; Ig_sub2. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR020722; Tyr_kinase_VEGF1_rcpt. DR InterPro; IPR020685; Tyr_prot_kinase. DR InterPro; IPR009135; Tyr_prot_kinase_VEGFR1_rcpt_N. DR InterPro; IPR009134; Tyr_prot_kinase_VEGFR_rcpt_N. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 5. DR PANTHER; PTHR23256:SF225; Tyr_kinase_VEGF1_rcpt; 1. DR PANTHER; PTHR23256; Tyr_prot_kinase; 1. DR Pfam; PF07679; I-set; 2. DR Pfam; PF07686; V-set; 1. DR PRINTS; PR01832; VEGFRECEPTOR. DR PRINTS; PR01833; VEGFRECEPTR1. DR SMART; SM00409; IG; 5. DR SMART; SM00408; IGc2; 1. DR PROSITE; PS50835; IG_LIKE; 4. PE 2: Evidence at transcript level; SQ SEQUENCE 688 AA; 77522 MW; 0301825F7F961A99 CRC64; MVSCWDTAVL PYALLGCLLL TGYGSGSKLK VPELSLKGTQ HVMQAGQTLF LKCRGEAAHS WSLPTTVSQE DKRLSITPPS ACGRDNRQFC STLTLDTAQA NHTGLYTCRY LPTSTSKKKK AESSIYIFVS DAGSPFIEMH TDIPKLVHMT EGRQLIIPCR VTSPNVTVTL KKFPFDTLTP DGQRITWDSR RGFIIANATY KEIGLLNCEA TVNGHLYQTN YLTHRQTNTI LDVQIRPPSP VRLLHGQTLV LNCTATTELN TRVQMSWNYP GKATKRASIR QRIDRSHSHN NVFHSVLKIN NVESRDKGLY TCRVKSGSSF QSFNTSVHVY EKGFISVKHR KQPVQETTAG RRSYRLSMKV KAFPSPEIVW LKDGSPATLK SARYLVHGYS LIIKDVTTED AGDYTILLGI KQSRLFKNLT ATLIVNVKPQ IYEKSVSSLP SPPLYPLGSR QVLTCTVYGI PRPTITWLWH PCHHNHSKER YDFCTENEES FILDPSSNLG NRIESISQRM TVIEGTNKTV STLVVADSQT PGIYSCRAFN KIGTVERNIK FYVTDVPNGF HVSLEKMPAE GEDLKLSCVV NKFLYRDITW ILLRTVNNRT MHHSISKQKM ATTQDYSITL NLVIKNVSLE DSGTYACRAR NIYTGEDILR KTEVLVRGEH CGKKAIFSRI SKFKSRRNDC TTQSHVKH //