ID O55054_MOUSE Unreviewed; 433 AA. AC O55054; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 04-FEB-2015, entry version 83. DE SubName: Full=T4 surface glycoprotein {ECO:0000313|EMBL:AAC01764.1}; DE Flags: Fragment; GN Name=Cd4 {ECO:0000313|MGI:MGI:88335}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC01764.1}; RN [1] {ECO:0000313|EMBL:AAC01764.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3501122; DOI=10.1073/pnas.84.24.9155; RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RT "Structure and expression of the human and mouse T4 genes."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9155-9159(1987). RN [2] {ECO:0000313|EMBL:AAC01764.1} RP NUCLEOTIDE SEQUENCE. RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF045882; AAC01764.1; -; mRNA. DR UniGene; Mm.2209; -. DR ProteinModelPortal; O55054; -. DR PRIDE; O55054; -. DR MGI; MGI:88335; Cd4. DR HOVERGEN; HBG005281; -. DR Genevestigator; O55054; -. DR GO; GO:0009986; C:cell surface; IDA:MGI. DR GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:MGI. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0045121; C:membrane raft; IDA:MGI. DR GO; GO:0005886; C:plasma membrane; IDA:MGI. DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro. DR GO; GO:0019899; F:enzyme binding; ISO:MGI. DR GO; GO:0001948; F:glycoprotein binding; ISO:MGI. DR GO; GO:0042803; F:protein homodimerization activity; ISO:MGI. DR GO; GO:0019901; F:protein kinase binding; ISO:MGI. DR GO; GO:0008270; F:zinc ion binding; ISO:MGI. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0007166; P:cell surface receptor signaling pathway; IDA:MGI. DR GO; GO:0001816; P:cytokine production; IMP:MGI. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IMP:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0006948; P:induction by virus of host cell-cell fusion; ISO:MGI. DR GO; GO:0032507; P:maintenance of protein location in cell; ISO:MGI. DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0045860; P:positive regulation of protein kinase activity; ISO:MGI. DR GO; GO:0050870; P:positive regulation of T cell activation; IDA:MGI. DR GO; GO:0045234; P:protein palmitoleylation; ISO:MGI. DR GO; GO:0050863; P:regulation of T cell activation; ISO:MGI. DR GO; GO:0030217; P:T cell differentiation; ISO:MGI. DR GO; GO:0045058; P:T cell selection; ISO:MGI. DR Gene3D; 2.60.40.10; -; 4. DR InterPro; IPR000973; CD4. DR InterPro; IPR015274; CD4-extracel. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR008424; Ig_C2-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003596; Ig_V-set_subgr. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR021963; Tcell_CD4_Cterm. DR Pfam; PF05790; C2-set; 2. DR Pfam; PF09191; CD4-extracel; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF12104; Tcell_CD4_Cterm; 1. DR PRINTS; PR00692; CD4TCANTIGEN. DR SMART; SM00409; IG; 2. DR SMART; SM00406; IGv; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Disulfide bond {ECO:0000256|SAAS:SAAS00049707}. FT NON_TER 1 1 {ECO:0000313|EMBL:AAC01764.1}. FT NON_TER 433 433 {ECO:0000313|EMBL:AAC01764.1}. SQ SEQUENCE 433 AA; 48590 MW; AB19330750A8499A CRC64; QGKTLVLGKE GESAELPCES SQKKITVFTW KFSDQRKILG QHGKGVLIRG GSPSQFDRFD SKKGAWEKGS FPLIINKLKM EDSQTYICEL ENRKEEVELW VFKVTFSPGT SLLQGQSLTL TLDSNSKVSN PLTECKHKKG KVVSGSKVLS MSNLRVQDSD FWNCTVTLDQ KKNWFGMTLS VLGFQSTAIT AYKSEGESAE FSFPLNFAEE NGWGELMWKA EKDSFFQPWI SFSIKNKEVS VQKSTKDLKL QLKETLPLTL KIPQVSLQFA GSGNLTLTLD KGTLHQEVNL VVMKVAQLNN TLTCEVMGPT SPKMRLTLKQ ENQEARVSEE QKVVQVVAPE TGLWQCLLSE GDKVKMDSRI QVLSRGVNQT VFLACVLGGS FAFLGFLGLC ILCCVRCRHQ QRQAARMSQI KRLLSEKKTC QCPHRMQKSH NLI //