ID O55054_MOUSE Unreviewed; 433 AA. AC O55054; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 05-APR-2011, entry version 62. DE SubName: Full=T4 surface glycoprotein; DE Flags: Fragment; GN Name=Cd4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=88097446; PubMed=3501122; DOI=10.1073/pnas.84.24.9155; RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RT "Structure and expression of the human and mouse T4 genes."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9155-9159(1987). RN [2] RP NUCLEOTIDE SEQUENCE. RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) CC domain. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF045882; AAC01764.1; -; mRNA. DR IPI; IPI00122806; -. DR UniGene; Mm.2209; -. DR HSSP; P05540; 1CID. DR ProteinModelPortal; O55054; -. DR STRING; O55054; -. DR MGI; MGI:88335; Cd4. DR eggNOG; roNOG17421; -. DR HOVERGEN; HBG005281; -. DR InParanoid; O55054; -. DR ArrayExpress; O55054; -. DR Bgee; O55054; -. DR Genevestigator; O55054; -. DR GO; GO:0005788; C:endoplasmic reticulum lumen; IDA:MGI. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:MGI. DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI. DR GO; GO:0016021; C:integral to membrane; IEA:InterPro. DR GO; GO:0045121; C:membrane raft; IDA:MGI. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0007166; P:cell surface receptor linked signaling pathway; IDA:MGI. DR GO; GO:0001816; P:cytokine production; IGI:MGI. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0050850; P:positive regulation of calcium-mediated signaling; IDA:MGI. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IDA:MGI. DR GO; GO:0050870; P:positive regulation of T cell activation; IDA:MGI. DR GO; GO:0051789; P:response to protein stimulus; IDA:MGI. DR InterPro; IPR000973; Ag_CD4. DR InterPro; IPR015274; CD4-extracel. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR008424; Ig_C2-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR003596; Ig_V-set_sub. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR021963; Tcell_CD4_Cterm. DR Gene3D; G3DSA:2.60.40.10; Ig-like_fold; 4. DR Pfam; PF05790; C2-set; 2. DR Pfam; PF09191; CD4-extracel; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF12104; Tcell_CD4_Cterm; 1. DR PRINTS; PR00692; CD4TCANTIGEN. DR SMART; SM00409; IG; 2. DR SMART; SM00406; IGv; 1. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Immunoglobulin domain. FT NON_TER 1 1 FT NON_TER 433 433 SQ SEQUENCE 433 AA; 48590 MW; AB19330750A8499A CRC64; QGKTLVLGKE GESAELPCES SQKKITVFTW KFSDQRKILG QHGKGVLIRG GSPSQFDRFD SKKGAWEKGS FPLIINKLKM EDSQTYICEL ENRKEEVELW VFKVTFSPGT SLLQGQSLTL TLDSNSKVSN PLTECKHKKG KVVSGSKVLS MSNLRVQDSD FWNCTVTLDQ KKNWFGMTLS VLGFQSTAIT AYKSEGESAE FSFPLNFAEE NGWGELMWKA EKDSFFQPWI SFSIKNKEVS VQKSTKDLKL QLKETLPLTL KIPQVSLQFA GSGNLTLTLD KGTLHQEVNL VVMKVAQLNN TLTCEVMGPT SPKMRLTLKQ ENQEARVSEE QKVVQVVAPE TGLWQCLLSE GDKVKMDSRI QVLSRGVNQT VFLACVLGGS FAFLGFLGLC ILCCVRCRHQ QRQAARMSQI KRLLSEKKTC QCPHRMQKSH NLI //