ID O55054_MOUSE PRELIMINARY; PRT; 433 AA. AC O55054; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 21-FEB-2006, entry version 30. DE T4 surface glycoprotein (Fragment). GN Name=Cd4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=88097446; PubMed=3501122; RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RT "Structure and expression of the human and mouse T4 genes."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9155-9159(1987). RN [2] RP NUCLEOTIDE SEQUENCE. RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Accessory protein for MHC class-II antigen/T-cell CC receptor interaction. May regulate T-cell activation (By CC similarity). CC -!- SUBUNIT: Associates with p56-LCK (By similarity). CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF045882; AAC01764.1; -; mRNA. DR HSSP; P05540; 1CID. DR Ensembl; ENSMUSG00000023274; Mus musculus. DR MGI; MGI:88335; Cd4. DR GO; GO:0009897; C:external side of plasma membrane; IDA. DR GO; GO:0016021; C:integral to membrane; RCA. DR GO; GO:0042289; F:MHC class II protein binding; IDA. DR GO; GO:0007166; P:cell surface receptor linked signal transdu...; IDA. DR GO; GO:0050850; P:positive regulation of calcium-mediated sig...; IDA. DR GO; GO:0045086; P:positive regulation of interleukin-2 biosyn...; IDA. DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine ph...; IDA. DR GO; GO:0050870; P:positive regulation of T cell activation; IDA. DR InterPro; IPR008424; CD2. DR InterPro; IPR000973; CD4_TCAg. DR InterPro; IPR003599; Ig. DR InterPro; IPR007110; Ig-like. DR InterPro; IPR003596; Ig_v. DR InterPro; IPR013151; Immunoglobulin. DR Pfam; PF05790; C2-set; 2. DR PRINTS; PR00692; CD4TCANTIGEN. DR SMART; SM00409; IG; 3. DR SMART; SM00406; IGv; 1. DR PROSITE; PS50835; IG_LIKE; 1. KW Immunoglobulin domain. FT NON_TER 1 1 FT NON_TER 433 433 SQ SEQUENCE 433 AA; 48590 MW; AB19330750A8499A CRC64; QGKTLVLGKE GESAELPCES SQKKITVFTW KFSDQRKILG QHGKGVLIRG GSPSQFDRFD SKKGAWEKGS FPLIINKLKM EDSQTYICEL ENRKEEVELW VFKVTFSPGT SLLQGQSLTL TLDSNSKVSN PLTECKHKKG KVVSGSKVLS MSNLRVQDSD FWNCTVTLDQ KKNWFGMTLS VLGFQSTAIT AYKSEGESAE FSFPLNFAEE NGWGELMWKA EKDSFFQPWI SFSIKNKEVS VQKSTKDLKL QLKETLPLTL KIPQVSLQFA GSGNLTLTLD KGTLHQEVNL VVMKVAQLNN TLTCEVMGPT SPKMRLTLKQ ENQEARVSEE QKVVQVVAPE TGLWQCLLSE GDKVKMDSRI QVLSRGVNQT VFLACVLGGS FAFLGFLGLC ILCCVRCRHQ QRQAARMSQI KRLLSEKKTC QCPHRMQKSH NLI //