ID O55054_MOUSE Unreviewed; 433 AA. AC O55054; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 24-JUL-2024, entry version 120. DE RecName: Full=T-cell surface glycoprotein CD4 {ECO:0000256|ARBA:ARBA00016522}; DE AltName: Full=T-cell surface antigen T4/Leu-3 {ECO:0000256|ARBA:ARBA00029974}; DE Flags: Fragment; GN Name=Cd4 {ECO:0000313|MGI:MGI:88335}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC01764.1}; RN [1] {ECO:0000313|EMBL:AAC01764.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3501122; DOI=10.1073/pnas.84.24.9155; RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RT "Structure and expression of the human and mouse T4 genes."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9155-9159(1987). RN [2] {ECO:0000313|EMBL:AAC01764.1} RP NUCLEOTIDE SEQUENCE. RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004479}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF045882; AAC01764.1; -; mRNA. DR AlphaFoldDB; O55054; -. DR AGR; MGI:88335; -. DR MGI; MGI:88335; Cd4. DR GO; GO:0009897; C:external side of plasma membrane; IEA:TreeGrafter. DR GO; GO:0045121; C:membrane raft; IEA:TreeGrafter. DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro. DR GO; GO:0042289; F:MHC class II protein binding; IEA:TreeGrafter. DR GO; GO:1990782; F:protein tyrosine kinase binding; IEA:TreeGrafter. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0035723; P:interleukin-15-mediated signaling pathway; IEA:TreeGrafter. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:TreeGrafter. DR GO; GO:0042110; P:T cell activation; IEA:TreeGrafter. DR CDD; cd22570; CD4_CD; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 4. DR Gene3D; 1.20.5.900; transmembrane domain of human cd4; 1. DR InterPro; IPR000973; CD4. DR InterPro; IPR015274; CD4-extracel. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR008424; Ig_C2-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR021963; Tcell_CD4_Cterm. DR PANTHER; PTHR11422; T-CELL SURFACE GLYCOPROTEIN CD4; 1. DR PANTHER; PTHR11422:SF0; T-CELL SURFACE GLYCOPROTEIN CD4; 1. DR Pfam; PF05790; C2-set; 2. DR Pfam; PF09191; CD4-extracel; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF12104; Tcell_CD4_C; 1. DR PRINTS; PR00692; CD4TCANTIGEN. DR SMART; SM00409; IG; 3. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; Immunoglobulin; 4. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 371..397 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..98 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAC01764.1" FT NON_TER 433 FT /evidence="ECO:0000313|EMBL:AAC01764.1" SQ SEQUENCE 433 AA; 48590 MW; AB19330750A8499A CRC64; QGKTLVLGKE GESAELPCES SQKKITVFTW KFSDQRKILG QHGKGVLIRG GSPSQFDRFD SKKGAWEKGS FPLIINKLKM EDSQTYICEL ENRKEEVELW VFKVTFSPGT SLLQGQSLTL TLDSNSKVSN PLTECKHKKG KVVSGSKVLS MSNLRVQDSD FWNCTVTLDQ KKNWFGMTLS VLGFQSTAIT AYKSEGESAE FSFPLNFAEE NGWGELMWKA EKDSFFQPWI SFSIKNKEVS VQKSTKDLKL QLKETLPLTL KIPQVSLQFA GSGNLTLTLD KGTLHQEVNL VVMKVAQLNN TLTCEVMGPT SPKMRLTLKQ ENQEARVSEE QKVVQVVAPE TGLWQCLLSE GDKVKMDSRI QVLSRGVNQT VFLACVLGGS FAFLGFLGLC ILCCVRCRHQ QRQAARMSQI KRLLSEKKTC QCPHRMQKSH NLI //