ID O55054_MOUSE Unreviewed; 433 AA. AC O55054; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 01-JUN-1998, sequence version 1. DT 12-AUG-2020, entry version 103. DE RecName: Full=T-cell surface antigen T4/Leu-3 {ECO:0000256|ARBA:ARBA00019908}; DE AltName: Full=T-cell surface glycoprotein CD4 {ECO:0000256|ARBA:ARBA00016522}; DE Flags: Fragment; GN Name=Cd4 {ECO:0000313|MGI:MGI:88335}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAC01764.1}; RN [1] {ECO:0000313|EMBL:AAC01764.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=3501122; DOI=10.1073/pnas.84.24.9155; RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RT "Structure and expression of the human and mouse T4 genes."; RL Proc. Natl. Acad. Sci. U.S.A. 84:9155-9159(1987). RN [2] {ECO:0000313|EMBL:AAC01764.1} RP NUCLEOTIDE SEQUENCE. RA Maddon P.J., Molineaux S.M., Maddon D.E., Zimmerman K.A., Godfrey M., RA Alt F.W., Chess L., Axel R.; RL Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251}; CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}. CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane CC protein {ECO:0000256|ARBA:ARBA00004479}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF045882; AAC01764.1; -; mRNA. DR EPD; O55054; -. DR MGI; MGI:88335; Cd4. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR Gene3D; 2.60.40.10; -; 4. DR InterPro; IPR000973; CD4. DR InterPro; IPR015274; CD4-extracel. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR008424; Ig_C2-set. DR InterPro; IPR003599; Ig_sub. DR InterPro; IPR013106; Ig_V-set. DR InterPro; IPR013151; Immunoglobulin. DR InterPro; IPR021963; Tcell_CD4_Cterm. DR PANTHER; PTHR11422:SF0; PTHR11422:SF0; 1. DR Pfam; PF05790; C2-set; 2. DR Pfam; PF09191; CD4-extracel; 1. DR Pfam; PF00047; ig; 1. DR Pfam; PF12104; Tcell_CD4_C; 1. DR PRINTS; PR00692; CD4TCANTIGEN. DR SMART; SM00409; IG; 3. DR SMART; SM00406; IGv; 1. DR SUPFAM; SSF48726; SSF48726; 4. DR PROSITE; PS50835; IG_LIKE; 1. PE 2: Evidence at transcript level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Signal {ECO:0000256|ARBA:ARBA00022729}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 371..397 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..98 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AAC01764.1" FT NON_TER 433 FT /evidence="ECO:0000313|EMBL:AAC01764.1" SQ SEQUENCE 433 AA; 48590 MW; AB19330750A8499A CRC64; QGKTLVLGKE GESAELPCES SQKKITVFTW KFSDQRKILG QHGKGVLIRG GSPSQFDRFD SKKGAWEKGS FPLIINKLKM EDSQTYICEL ENRKEEVELW VFKVTFSPGT SLLQGQSLTL TLDSNSKVSN PLTECKHKKG KVVSGSKVLS MSNLRVQDSD FWNCTVTLDQ KKNWFGMTLS VLGFQSTAIT AYKSEGESAE FSFPLNFAEE NGWGELMWKA EKDSFFQPWI SFSIKNKEVS VQKSTKDLKL QLKETLPLTL KIPQVSLQFA GSGNLTLTLD KGTLHQEVNL VVMKVAQLNN TLTCEVMGPT SPKMRLTLKQ ENQEARVSEE QKVVQVVAPE TGLWQCLLSE GDKVKMDSRI QVLSRGVNQT VFLACVLGGS FAFLGFLGLC ILCCVRCRHQ QRQAARMSQI KRLLSEKKTC QCPHRMQKSH NLI //