ID ECCA3_MYCTU Reviewed; 631 AA. AC O53687; DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot. DT 01-JUN-1998, sequence version 1. DT 08-FEB-2011, entry version 68. DE RecName: Full=ESX-3 secretion system protein EccA3; DE AltName: Full=ESX conserved component A3; DE AltName: Full=Type VII secretion system protein EccA3; DE Short=T7SS protein EccA3; GN Name=eccA3; OrderedLocusNames=Rv0282, MT0295; ORFNames=MTV035.10; OS Mycobacterium tuberculosis. OC Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; OC Corynebacterineae; Mycobacteriaceae; Mycobacterium; OC Mycobacterium tuberculosis complex. OX NCBI_TaxID=1773; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 25618 / H37Rv; RX MEDLINE=98295987; PubMed=9634230; DOI=10.1038/31159; RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., RA Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, RA Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T., RA Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N., RA Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S., RA Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A., RA Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R., RA Sulston J.E., Taylor K., Whitehead S., Barrell B.G.; RT "Deciphering the biology of Mycobacterium tuberculosis from the RT complete genome sequence."; RL Nature 393:537-544(1998). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CDC 1551 / Oshkosh; RX MEDLINE=22206494; PubMed=12218036; RX DOI=10.1128/JB.184.19.5479-5490.2002; RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O., RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., RA Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., RA Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., RA Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C., RA Fraser C.M.; RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and RT laboratory strains."; RL J. Bacteriol. 184:5479-5490(2002). RN [3] RP GENE NAME. RX PubMed=19876390; DOI=10.1371/journal.ppat.1000507; RA Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S., RA Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C., RA Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.; RT "Systematic genetic nomenclature for type VII secretion systems."; RL PLoS Pathog. 5:E1000507-E1000507(2009). CC -!- FUNCTION: Shows ATPase activity. Could provide energy for export CC of ESX-3 substrates (By similarity). CC -!- SUBUNIT: Part of the ESX-3 / type VII secretion system (T7SS), CC which is composed of cytosolic and membrane components (By CC similarity). CC -!- SUBCELLULAR LOCATION: Cytoplasm (Potential). CC -!- SIMILARITY: Belongs to the cbxX/cfxQ family. CC -!- SEQUENCE CAUTION: CC Sequence=AAK44519.1; Type=Erroneous initiation; Note=Translation N-terminally extended; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BX842573; CAA17357.1; -; Genomic_DNA. DR EMBL; AE000516; AAK44519.1; ALT_INIT; Genomic_DNA. DR PIR; H70835; H70835. DR RefSeq; NP_214796.1; NC_000962.2. DR RefSeq; NP_334705.1; NC_002755.2. DR ProteinModelPortal; O53687; -. DR SMR; O53687; 340-582. DR EnsemblBacteria; EBMYCT00000003491; EBMYCP00000003491; EBMYCG00000003489. DR EnsemblBacteria; EBMYCT00000072986; EBMYCP00000071045; EBMYCG00000072981. DR GeneID; 886613; -. DR GeneID; 923238; -. DR GenomeReviews; AE000516_GR; MT0295. DR GenomeReviews; AL123456_GR; Rv0282. DR KEGG; mtc:MT0295; -. DR KEGG; mtu:Rv0282; -. DR TIGR; MT0295; -. DR TubercuList; Rv0282; -. DR GeneTree; EBGT00050000015038; -. DR HOGENOM; HBG569278; -. DR OMA; VIVAGYR; -. DR ProtClustDB; CLSK790401; -. DR GO; GO:0005618; C:cell wall; IDA:MTBBASE. DR GO; GO:0005829; C:cytosol; IDA:MTBBASE. DR GO; GO:0005886; C:plasma membrane; IDA:MTBBASE. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0017111; F:nucleoside-triphosphatase activity; IEA:InterPro. DR GO; GO:0010106; P:cellular response to iron ion starvation; IEP:MTBBASE. DR GO; GO:0040007; P:growth; IMP:MTBBASE. DR GO; GO:0033214; P:iron assimilation by chelation and transport; IMP:MTBBASE. DR InterPro; IPR003593; ATPase_AAA+_core. DR InterPro; IPR003959; ATPase_AAA_core. DR InterPro; IPR000641; CbxX_CfqX. DR Pfam; PF00004; AAA; 1. DR PRINTS; PR00819; CBXCFQXSUPER. DR SMART; SM00382; AAA; 1. PE 3: Inferred from homology; KW ATP-binding; Complete proteome; Cytoplasm; Nucleotide-binding. FT CHAIN 1 631 ESX-3 secretion system protein EccA3. FT /FTId=PRO_0000063045. FT NP_BIND 385 392 ATP (Potential). SQ SEQUENCE 631 AA; 68107 MW; BE4D492E351C6C53 CRC64; MAGVGEGDSG GVERDDIGMV AASPVASRVN GKVDADVVGR FATCCRALGI AVYQRKRPPD LAAARSGFAA LTRVAHDQCD AWTGLAAAGD QSIGVLEAAS RTATTAGVLQ RQVELADNAL GFLYDTGLYL RFRATGPDDF HLAYAAALAS TGGPEEFAKA NHVVSGITER RAGWRAARWL AVVINYRAER WSDVVKLLTP MVNDPDLDEA FSHAAKITLG TALARLGMFA PALSYLEEPD GPVAVAAVDG ALAKALVLRA HVDEESASEV LQDLYAAHPE NEQVEQALSD TSFGIVTTTA GRIEARTDPW DPATEPGAED FVDPAAHERK AALLHEAELQ LAEFIGLDEV KRQVSRLKSS VAMELVRKQR GLTVAQRTHH LVFAGPPGTG KTTIARVVAK IYCGLGLLKR ENIREVHRAD LIGQHIGETE AKTNAIIDSA LDGVLFLDEA YALVATGAKN DFGLVAIDTL LARMENDRDR LVVIIAGYRA DLDKFLDTNE GLRSRFTRNI DFPSYTSHEL VEIAHKMAEQ RDSVFEQSAL HDLEALFAKL AAESTPDTNG ISRRSLDIAG NGRFVRNIVE RSEEEREFRL DHSEHAGSGE FSDEELMTIT ADDVGRSVEP LLRGLGLSVR A //