ID   O53533_MYCTU            Unreviewed;       361 AA.
AC   O53533; Q7D7D0;
DT   01-JUN-1998, integrated into UniProtKB/TrEMBL.
DT   01-JUN-1998, sequence version 1.
DT   15-DEC-2009, entry version 67.
DE   SubName: Full=Probable zinc-dependent alcohol dehydrogenase AdhE2;
DE            EC=1.2.1.-;
DE   SubName: Full=Zinc-binding dehydrogenase;
GN   Name=adhE2; OrderedLocusNames=MT2320, Rv2259;
OS   Mycobacterium tuberculosis.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium;
OC   Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1773;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   MEDLINE=98295987; PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M.,
RA   Harris D.E., Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III,
RA   Tekaia F., Badcock K., Basham D., Brown D., Chillingworth T.,
RA   Connor R., Davies R.M., Devlin K., Feltwell T., Gentles S., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Krogh A., McLean J., Moule S.,
RA   Murphy L.D., Oliver S., Osborne J., Quail M.A., Rajandream M.A.,
RA   Rogers J., Rutter S., Seeger K., Skelton S., Squares S., Squares R.,
RA   Sulston J.E., Taylor K., Whitehead S., Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the
RT   complete genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   MEDLINE=22206494; PubMed=12218036;
RX   DOI=10.1128/JB.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H.,
RA   Hickey E.K., Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D.,
RA   Salzberg S.L., Delcher A., Utterback T.R., Weidman J.F., Khouri H.M.,
RA   Gill J., Mikula A., Bishai W., Jacobs W.R. Jr., Venter J.C.,
RA   Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- COFACTOR: Zinc (By similarity).
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family.
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DR   EMBL; AE000516; AAK46602.1; -; Genomic_DNA.
DR   EMBL; BX842579; CAA17296.1; -; Genomic_DNA.
DR   PIR; G70862; G70862.
DR   RefSeq; NP_216775.1; -.
DR   RefSeq; NP_336788.1; -.
DR   HSSP; P00327; 1A71.
DR   HSSP; Q59096; 1F8F.
DR   GeneID; 887215; -.
DR   GeneID; 924106; -.
DR   GenomeReviews; AE000516_GR; MT2320.
DR   GenomeReviews; AL123456_GR; Rv2259.
DR   KEGG; mtc:MT2320; -.
DR   KEGG; mtu:Rv2259; -.
DR   TIGR; MT2320; -.
DR   TubercuList; Rv2259; -.
DR   HOGENOM; O53533; -.
DR   OMA; RDGGIND; -.
DR   BioCyc; MetaCyc:MON-9721; -.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR013154; ADH_GroES-like.
DR   InterPro; IPR002085; ADH_SF_Zn.
DR   InterPro; IPR013149; ADH_Zn-bd.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR017816; FormAld_DH_mycothiol-dep.
DR   InterPro; IPR011032; GroES-like.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   PANTHER; PTHR11695; ADH_Sf_Zn; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   TIGRFAMs; TIGR03451; mycoS_dep_FDH; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Metal-binding; Oxidoreductase; Zinc.
SQ   SEQUENCE   361 AA;  37888 MW;  750A7A1EA8CC5593 CRC64;
     MSQTVRGVIA RQKGEPVELV NIVVPDPGPG EAVVDVTACG VCHTDLTYRE GGINDEYPFL
     LGHEAAGIIE AVGPGVTAVE PGDFVILNWR AVCGQCRACK RGRPRYCFDT FNAEQKMTLT
     DGTELTAALG IGAFADKTLV HSGQCTKVDP AADPAVAGLL GCGVMAGLGA AINTGGVTRD
     DTVAVIGCGG VGDAAIAGAA LVGAKRIIAV DTDDTKLDWA RTFGATHTVN AREVDVVQAI
     GGLTDGFGAD VVIDAVGRPE TYQQAFYARD LAGTVVLVGV PTPDMRLDMP LVDFFSHGGA
     LKSSWYGDCL PESDFPTLID LYLQGRLPLQ RFVSERIGLE DVEEAFHKMH GGKVLRSVVM
     L
//