ID O44940_DROME Unreviewed; 606 AA. AC O44940; O46104; DT 01-JUN-1998, integrated into UniProtKB/TrEMBL. DT 05-JUL-2004, sequence version 2. DT 02-DEC-2020, entry version 108. DE SubName: Full=Drosophila multidendritic neurons sodium channel 1 {ECO:0000313|EMBL:CAA76124.1}; GN Name=ppk {ECO:0000313|FlyBase:FBgn0020258}; GN Synonyms=dmdNaC1 {ECO:0000313|EMBL:CAA76124.1}; GN ORFNames=CG3478 {ECO:0000313|FlyBase:FBgn0020258}; OS Drosophila melanogaster (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila; Sophophora. OX NCBI_TaxID=7227 {ECO:0000313|EMBL:CAA76124.1}; RN [1] {ECO:0000313|EMBL:CAA76124.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Whole fly {ECO:0000313|EMBL:CAA76124.1}; RX PubMed=9600094; DOI=10.1006/bbrc.1998.8183; RA Darboux I., Lingueglia E., Pauron D., Barbry P., Lazdunski M.; RT "A new member of the amiloride-sensitive sodium channel family in RT Drosophila melanogaster peripheral nervous system."; RL Biochem. Biophys. Res. Commun. 246:210-216(1998). CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel CC (TC 1.A.6) family. {ECO:0000256|ARBA:ARBA00007193, CC ECO:0000256|RuleBase:RU000679}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Y16225; CAA76124.1; -; mRNA. DR PIR; JW0054; JW0054. DR FlyBase; FBgn0020258; ppk. DR HOGENOM; CLU_024950_1_1_1; -. DR Bgee; FBgn0020258; Expressed in antenna and 17 other tissues. DR ExpressionAtlas; O44940; baseline and differential. DR GO; GO:0032590; C:dendrite membrane; IDA:FlyBase. DR GO; GO:0016021; C:integral component of membrane; ISS:FlyBase. DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central. DR GO; GO:0044736; F:acid-sensing ion channel activity; IMP:FlyBase. DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central. DR GO; GO:0005272; F:sodium channel activity; ISS:FlyBase. DR GO; GO:0048266; P:behavioral response to pain; IMP:FlyBase. DR GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:FlyBase. DR GO; GO:0008345; P:larval locomotory behavior; IMP:FlyBase. DR GO; GO:0035179; P:larval turning behavior; IMP:FlyBase. DR GO; GO:0007638; P:mechanosensory behavior; IMP:FlyBase. DR GO; GO:2000252; P:negative regulation of feeding behavior; IMP:FlyBase. DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0006814; P:sodium ion transport; ISS:FlyBase. DR InterPro; IPR001873; ENaC. DR InterPro; IPR020903; ENaC_CS. DR PANTHER; PTHR11690; PTHR11690; 1. DR Pfam; PF00858; ASC; 1. DR PRINTS; PR01078; AMINACHANNEL. DR PROSITE; PS01206; ASC; 1. PE 2: Evidence at transcript level; KW Ion channel {ECO:0000256|RuleBase:RU000679, ECO:0000313|EMBL:CAA76124.1}; KW Ion transport {ECO:0000256|RuleBase:RU000679}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Sodium {ECO:0000256|ARBA:ARBA00023053}; KW Sodium channel {ECO:0000256|ARBA:ARBA00022461, KW ECO:0000256|RuleBase:RU000679}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201, KW ECO:0000256|RuleBase:RU000679}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000679, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU000679}. FT TRANSMEM 92..110 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 559..580 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" SQ SEQUENCE 606 AA; 69382 MW; 4FA457ED111F7C3B CRC64; MAEIREDEEE KKSGISILPG PELLALPGFD TRASIASAAL SDVPSDVIIK SRIRYGSPLS ACKGLLLEYA KSTTIHGIRY IFEVHRPIYE KLYWLFFTCI SVYFAVSLIW DTYLKWQESP VILGFDETLV PVHKIPFPTI TICPEIKMER NVFDYTNVSR QLWEEYKQNG NISDLDDEDL ARMAVAMHIC DSEVVQRFTP LLSQLNPPNV DVTQTLIDLS ISKNETGPFC KWNGRFYFCD KIFDFVATDE GICYQFNGLR PKDIYRDEKF ISYVDPDVVD FNKYFDVDLP PWNNITGNWS LDTGFVDQGQ NAYPQRTVFS SVKNGFFAFL QGLQHNFDYD CRSFKQGYKV FLNSPESVPL TTGNYILVPH GDEVLVSVLP AYVVSTDNLH EITPEKRQCL FDDERSLRFF RSYSQSNCQT ECLANYTVSK CGCAKFWMPK PLGTPVCGLK DINCYTSAQD ELYTLMQNQT MAKSIDESVD ITCNCMPACT SLEYNFEISR AKYDVAKTIR AFREEYEHTD AIGSRLSVYF KEHQFTAIKR TILFGVSTLI SNCGGICGLF MGISCLSFLE LIYFFCMRIC GSCRDRRKHK IQQQNSVDLP EENSEN //