ID   OR1F1_HUMAN             Reviewed;         312 AA.
AC   O43749; O15246; Q6IFL5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 177.
DE   RecName: Full=Olfactory receptor 1F1;
DE   AltName: Full=Olfactory receptor 16-35;
DE            Short=OR16-35;
DE   AltName: Full=Olfactory receptor 1F10;
DE   AltName: Full=Olfactory receptor 1F4;
DE   AltName: Full=Olfactory receptor 1F5;
DE   AltName: Full=Olfactory receptor 1F6;
DE   AltName: Full=Olfactory receptor 1F7;
DE   AltName: Full=Olfactory receptor 1F8;
DE   AltName: Full=Olfactory receptor 1F9;
DE   AltName: Full=Olfactory receptor OR16-4;
GN   Name=OR1F1;
GN   Synonyms=OLFMF, OR1F10, OR1F4, OR1F5, OR1F6, OR1F7, OR1F8, OR1F9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=9288094; DOI=10.1038/ng0997-25;
RA   Bernot A., Clepet C., Dasilva C., Devaud C., Petit J.-L., Caloustian C.,
RA   Cruaud C., Samson D., Pulcini F., Weissenbach J., Heilig R., Notanicola C.,
RA   Domingo C., Rozenbaum M., Benchetrit E., Topaloglu R., Dewalle M.,
RA   Dross C., Hadjari P., Dupont M., Demaille J.G., Touitou I., Smaoui N.,
RA   Nedelec B., Mery J.-P., Chaabouni H., Delpech M., Grateau G.;
RT   "A candidate gene for familial Mediterranean fever.";
RL   Nat. Genet. 17:25-31(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9653642; DOI=10.1006/geno.1998.5313;
RA   Bernot A., Heilig R., Clepet C., Smaoui N., Da Silva C., Petit J.-L.,
RA   Devaud C., Chiannilkulchai N., Fizames C., Samson D., Cruaud C.,
RA   Caloustian C., Gyapay G., Delpech M., Weissenbach J.;
RT   "A transcriptional map of the FMF region.";
RL   Genomics 50:147-160(1998).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=9500546; DOI=10.1038/ng0398-243;
RA   Rouquier S., Taviaux S., Trask B.J., Brand-Arpon V., Van den Engh G.,
RA   Demaille J.G., Giorgi D.;
RT   "Distribution of olfactory receptor genes in the human genome.";
RL   Nat. Genet. 18:243-250(1998).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX   PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA   Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA   Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA   Lehrach H., Lancet D., Shamir R.;
RT   "DEFOG: a practical scheme for deciphering families of genes.";
RL   Genomics 80:295-302(2002).
RN   [7]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [8]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR1F1";
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DR   EMBL; Y14442; CAA74794.1; -; mRNA.
DR   EMBL; AJ003147; CAA05903.1; -; Genomic_DNA.
DR   EMBL; AB065907; BAC06122.1; -; Genomic_DNA.
DR   EMBL; BC069335; AAH69335.1; -; mRNA.
DR   EMBL; U86234; AAC39614.1; -; Genomic_DNA.
DR   EMBL; AF399559; AAK95044.1; -; Genomic_DNA.
DR   EMBL; BK004247; DAA04645.1; -; Genomic_DNA.
DR   CCDS; CCDS10496.1; -.
DR   RefSeq; NP_036492.1; NM_012360.1.
DR   RefSeq; XP_011520809.1; XM_011522507.2.
DR   AlphaFoldDB; O43749; -.
DR   SMR; O43749; -.
DR   STRING; 9606.ENSP00000305424; -.
DR   GlyGen; O43749; 1 site.
DR   PhosphoSitePlus; O43749; -.
DR   BioMuta; OR1F1; -.
DR   PaxDb; O43749; -.
DR   PeptideAtlas; O43749; -.
DR   PRIDE; O43749; -.
DR   Antibodypedia; 68201; 68 antibodies from 18 providers.
DR   DNASU; 4992; -.
DR   Ensembl; ENST00000304646.2; ENSP00000305424.2; ENSG00000168124.2.
DR   GeneID; 4992; -.
DR   KEGG; hsa:4992; -.
DR   UCSC; uc010uwu.3; human.
DR   CTD; 4992; -.
DR   DisGeNET; 4992; -.
DR   GeneCards; OR1F1; -.
DR   HGNC; HGNC:8194; OR1F1.
DR   HPA; ENSG00000168124; Tissue enhanced (brain).
DR   MIM; 603232; gene.
DR   neXtProt; NX_O43749; -.
DR   OpenTargets; ENSG00000168124; -.
DR   PharmGKB; PA32070; -.
DR   VEuPathDB; HostDB:ENSG00000168124; -.
DR   eggNOG; ENOG502RTWB; Eukaryota.
DR   GeneTree; ENSGT00940000153683; -.
DR   HOGENOM; CLU_012526_1_3_1; -.
DR   InParanoid; O43749; -.
DR   OMA; TAKMTHQ; -.
DR   OrthoDB; 902247at2759; -.
DR   PhylomeDB; O43749; -.
DR   TreeFam; TF337210; -.
DR   PathwayCommons; O43749; -.
DR   BioGRID-ORCS; 4992; 9 hits in 673 CRISPR screens.
DR   ChiTaRS; OR1F1; human.
DR   GeneWiki; OR1F1; -.
DR   GenomeRNAi; 4992; -.
DR   Pharos; O43749; Tdark.
DR   PRO; PR:O43749; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; O43749; protein.
DR   Bgee; ENSG00000168124; Expressed in cingulate cortex and 66 other tissues.
DR   Genevisible; O43749; HS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; NAS:ProtInc.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 1F1"
FT                   /id="PRO_0000150431"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..79
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        80..100
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..158
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        159..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..219
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        220..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..259
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        260..272
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         75
FT                   /note="F -> S (in dbSNP:rs1834026)"
FT                   /id="VAR_024086"
FT   VARIANT         126
FT                   /note="V -> M (in dbSNP:rs8045183)"
FT                   /id="VAR_053121"
FT   CONFLICT        191
FT                   /note="D -> N (in Ref. 1; CAA74794)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        305
FT                   /note="V -> I (in Ref. 1; CAA74794)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  34866 MW;  5C1E1708A18B10E4 CRC64;
     MSGTNQSSVS EFLLLGLSRQ PQQQHLLFVF FLSMYLATVL GNLLIILSVS IDSCLHTPMY
     FFLSNLSFVD ICFSFTTVPK MLANHILETQ TISFCGCLTQ MYFVFMFVDM DNFLLAVMAY
     DHFVAVCHPL HYTAKMTHQL CALLVAGLWV VANLNVLLHT LLMAPLSFCA DNAITHFFCD
     VTPLLKLSCS DTHLNEVIIL SEGALVMITP FLCILASYMH ITCTVLKVPS TKGRWKAFST
     CGSHLAVVLL FYSTIIAVYF NPLSSHSAEK DTMATVLYTV VTPMLNPFIY SLRNRYLKGA
     LKKVVGRVVF SV
//