ID   ZN208_HUMAN             Reviewed;        1280 AA.
AC   O43345;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   19-MAR-2014, sequence version 2.
DT   17-JUN-2020, entry version 175.
DE   RecName: Full=Zinc finger protein 208;
DE   AltName: Full=Zinc finger protein 91-like;
GN   Name=ZNF208; Synonyms=ZNF91L;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND ALTERNATIVE SPLICING (ISOFORM 2).
RX   PubMed=9724325; DOI=10.1101/gr.8.8.791;
RA   Eichler E.E., Hoffman S.M., Adamson A.A., Gordon L.A., McCready P.,
RA   Lamerdin J.E., Mohrenweiser H.W.;
RT   "Complex beta-satellite repeat structures and the expansion of the zinc
RT   finger gene cluster in 19p12.";
RL   Genome Res. 8:791-808(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=O43345-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=O43345-2; Sequence=VSP_053780, VSP_053781, VSP_053782;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AC003973; AAB94784.1; -; Genomic_DNA.
DR   CCDS; CCDS54240.1; -. [O43345-1]
DR   RefSeq; NP_009084.2; NM_007153.3. [O43345-1]
DR   SMR; O43345; -.
DR   STRING; 9606.ENSP00000380315; -.
DR   iPTMnet; O43345; -.
DR   PhosphoSitePlus; O43345; -.
DR   BioMuta; ZNF208; -.
DR   EPD; O43345; -.
DR   jPOST; O43345; -.
DR   MassIVE; O43345; -.
DR   PaxDb; O43345; -.
DR   PeptideAtlas; O43345; -.
DR   PRIDE; O43345; -.
DR   ProteomicsDB; 48906; -. [O43345-1]
DR   Antibodypedia; 68057; 4 antibodies.
DR   Ensembl; ENST00000397126; ENSP00000380315; ENSG00000160321. [O43345-1]
DR   GeneID; 7757; -.
DR   KEGG; hsa:7757; -.
DR   UCSC; uc021urr.2; human. [O43345-1]
DR   CTD; 7757; -.
DR   DisGeNET; 7757; -.
DR   EuPathDB; HostDB:ENSG00000160321.14; -.
DR   GeneCards; ZNF208; -.
DR   HGNC; HGNC:12999; ZNF208.
DR   HPA; ENSG00000160321; Low tissue specificity.
DR   MIM; 603977; gene.
DR   neXtProt; NX_O43345; -.
DR   OpenTargets; ENSG00000160321; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   GeneTree; ENSGT00940000165698; -.
DR   InParanoid; O43345; -.
DR   KO; K09228; -.
DR   OMA; RWCARRF; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; O43345; -.
DR   TreeFam; TF350794; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   BioGRID-ORCS; 7757; 2 hits in 797 CRISPR screens.
DR   ChiTaRS; ZNF208; human.
DR   GenomeRNAi; 7757; -.
DR   Pharos; O43345; Tdark.
DR   PRO; PR:O43345; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; O43345; protein.
DR   Bgee; ENSG00000160321; Expressed in substantia nigra and 108 other tissues.
DR   ExpressionAtlas; O43345; baseline and differential.
DR   Genevisible; O43345; HS.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; NAS:UniProtKB.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 18.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 37.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 23.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 36.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 38.
PE   2: Evidence at transcript level;
KW   Alternative splicing; DNA-binding; Metal-binding; Nucleus; Polymorphism;
KW   Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..1280
FT                   /note="Zinc finger protein 208"
FT                   /id="PRO_0000047454"
FT   DOMAIN          4..75
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         173..195
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         201..223
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         229..251
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         257..279
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         313..335
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         341..363
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         369..391
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         397..419
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         425..447
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         453..475
FT                   /note="C2H2-type 11"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         497..519
FT                   /note="C2H2-type 12"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         525..547
FT                   /note="C2H2-type 13"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         553..575
FT                   /note="C2H2-type 14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         581..603
FT                   /note="C2H2-type 15"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         609..631
FT                   /note="C2H2-type 16"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         637..659
FT                   /note="C2H2-type 17"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         665..687
FT                   /note="C2H2-type 18"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         693..715
FT                   /note="C2H2-type 19"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         721..743
FT                   /note="C2H2-type 20"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         749..771
FT                   /note="C2H2-type 21"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         777..799
FT                   /note="C2H2-type 22"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         805..827
FT                   /note="C2H2-type 23"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         833..855
FT                   /note="C2H2-type 24"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         861..883
FT                   /note="C2H2-type 25"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         889..911
FT                   /note="C2H2-type 26"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         917..939
FT                   /note="C2H2-type 27"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         945..967
FT                   /note="C2H2-type 28"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         973..995
FT                   /note="C2H2-type 29; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1001..1023
FT                   /note="C2H2-type 30"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1029..1051
FT                   /note="C2H2-type 31"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1057..1079
FT                   /note="C2H2-type 32"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1085..1107
FT                   /note="C2H2-type 33"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1113..1135
FT                   /note="C2H2-type 34"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1141..1163
FT                   /note="C2H2-type 35"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1169..1191
FT                   /note="C2H2-type 36"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1197..1219
FT                   /note="C2H2-type 37"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1225..1247
FT                   /note="C2H2-type 38"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         1253..1275
FT                   /note="C2H2-type 39"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VAR_SEQ         464..563
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_053780"
FT   VAR_SEQ         955..983
FT                   /note="KSSSTLSYHKKIHTEEKPYKYEECGKGFS -> N (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_053781"
FT   VAR_SEQ         1277..1280
FT                   /note="GEKL -> GVPNPPTHKKIHAGEKLYK (in isoform 2)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_053782"
FT   VARIANT         282
FT                   /note="E -> K (in dbSNP:rs2007506)"
FT                   /id="VAR_052791"
FT   VARIANT         298
FT                   /note="S -> L (in dbSNP:rs12462668)"
FT                   /id="VAR_052792"
FT   VARIANT         456
FT                   /note="E -> Q (in dbSNP:rs7255075)"
FT                   /id="VAR_052793"
FT   VARIANT         640
FT                   /note="K -> E (in dbSNP:rs10425763)"
FT                   /id="VAR_059903"
FT   VARIANT         1035
FT                   /note="D -> G (in dbSNP:rs8108957)"
FT                   /id="VAR_059904"
SQ   SEQUENCE   1280 AA;  147487 MW;  296AEB9EF588A8DB CRC64;
     MGSLTFRDVA IEFSLEEWQC LDTAQQNLYR NVMLENYRNL VFLGIAAFKP DLIIFLEEGK
     ESWNMKRHEM VEESPVICSH FAQDLWPEQG IEDSFQKVIL RRYEKCGHEN LHLKIGYTNV
     DECKVHKEGY NKLNQSLTTT QSKVFQRGKY ANVFHKCSNS NRHKIRHTGK KHLQCKEYVR
     SFCMLSHLSQ HKRIYTRENS YKCEEGGKAF NWSSTLTYYK SAHTGEKPYR CKECGKAFSK
     FSILTKHKVI HTGEKSYKCE ECGKAFNQSA ILTKHKIIHT GEKPNKCEEC GKAFSKVSTL
     TTHKAIHAGE KPYKCKECGK AFSKVSTLIT HKAIHAGEKP YKCKECGKAF SKFSILTKHK
     VIHTGEKPYK CEECGKAYKW PSTLSYHKKI HTGEKPYKCE ECGKGFSMFS ILTKHEVIHT
     GEKPYKCEEC GKAFNWSSNL MEHKKIHTGE TPYKCEECGK GFSMFSILTK HKVIHNGEKP
     YKCEECDKAT HAGEKPYKCE ECGKAFNWSS NLMEHKRIHT GEKPYKCEEC GKSFSTFSIL
     TKHKVIHTGE KPYKCEECGK AYKWSSTLSY HKKIHTVEKP YKCEECGKAF NQSAILIKHK
     RIHTGEKPYK CEECGKTFSK VSTLTTHKAI HAGEKPYKCK ECGKTFIKVS TLTTHKAIHA
     GEKPYKCKEC GKAFSKFSIL TKHKVIHTGE KPYKCEECGK AFNWSSNLME HKRIHTGEKP
     YKCEECGKSF STFSVLTKHK VIHTGEKPYK CEECGKAYKW SSTLSYHKKI HTVEKPYKCE
     ECGKAFNRSA ILIKHKRIHT DEKPYKCEEC GKTFSKVSTL TTHKAIHAGE KPYKCKECGK
     AFSKFSILTK HKVIHTGEKP YKCEECGKAY KWPSTLSYHK KIHTGEKPYK CEECGKGFSM
     FSILTKHEVI HTGEKPYKCE ECGKAFSWLS VFSKHKKTHA GEKFYKCEAC GKAYKSSSTL
     SYHKKIHTEE KPYKYEECGK GFSTFSILTK HKVIHTGEKP YKCEECGKAF NWSSNLMEHK
     KIHTGETPYK CEECDKAFSW PSSLTEHKAT HAGEKPYKCE ECGKAFSWPS RLTEHKATHA
     GEEPYKCEEC GKAFNWSSNL MEHKRIHTGE KPYKCEECGK SFSTFSILTK HKVIHTGEKP
     YKCEECGKAY KWSSTLSYHK KIHTVEKPYK CEECGKGFVM FSILAKHKVI HTGEKLYKCE
     ECGKAYKWPS TLRYHKKIHT GEKPYKCEEC GKAFSTFSIL TKHKVIHTGE KPYKCEECGK
     AFSWLSVFSK HKKIHTGEKL
//