ID IM44_MOUSE STANDARD; PRT; 452 AA. AC O35857; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 15-JUL-1999 (Rel. 38, Last annotation update) DE MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44 DE PRECURSOR. GN MIMT44 OR TIM44. OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; OC Eutheria; Rodentia; Sciurognathi; Muridae; Murinae; Mus. RN [1] RP SEQUENCE FROM N.A. RC STRAIN=CD-1; TISSUE=KIDNEY; RX MEDLINE; 98081841. RA WADA J., KANWAR Y.S.; RT "Characterization of mammalian translocase of inner mitochondrial RT membrane (Tim44) isolated from diabetic newborn mouse kidney."; RL Proc. Natl. Acad. Sci. U.S.A. 95:144-149(1998). CC -!- FUNCTION: INVOLVED IN PROTEIN IMPORT INTO THE MITOCHONDRION. CC PROBABLY INVOLVED IN TRANSLOCATION ACROSS THE INNER MEMBRANE. AS A CC BINDING PROTEIN REQUIRED FOR DRIVING THE IMPORT OF PREPROTEINS. CC RECRUITS MITOCHONDRIAL HSP70 TO DRIVE PROTEIN TRANSLOCATION INTO CC THE MATRIX USING ATP AS AN ENERGY SOURCE. CC -!- SUBUNIT: FORMS PART OF THE RECEPTOR COMPLEX THAT CONSISTS OF AT CC LEAST 3 DIFFERENT PROTEINS (TIM17, TIM23, TIM44) (BY SIMILARITY). CC -!- SUBCELLULAR LOCATION: MITOCHONDRIAL INNER MEMBRANE. CC -!- SIMILARITY: BELONGS TO THE TIM44 FAMILY. CC -------------------------------------------------------------------------- CC This SWISS-PROT entry is copyright. It is produced through a collaboration CC between the Swiss Institute of Bioinformatics and the EMBL outstation - CC the European Bioinformatics Institute. There are no restrictions on its CC use by non-profit institutions as long as its content is in no way CC modified and this statement is not removed. Usage by and for commercial CC entities requires a license agreement (See http://www.isb-sib.ch/announce/ CC or send an email to license@isb-sib.ch). CC -------------------------------------------------------------------------- CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U69898; AAB97624.1; -. DR MGD; MGI:1196619; MIMT44. KW Mitochondrion; Inner membrane; Transport; Protein transport; KW Translocation; Transit peptide; ATP-binding. FT TRANSIT 1 ? MITOCHONDRION. FT CHAIN ? 452 MITOCHONDRIAL IMPORT INNER MEMBRANE FT TRANSLOCASE SUBUNIT TIM44. FT NP_BIND 166 173 ATP (POTENTIAL). SQ SEQUENCE 452 AA; 51176 MW; EA25A282 CRC32; MAAARLRGGW CRCPRRCLGS GIQFLSSHNL PHGSSYQISR PGRELTLTKS YSSGSRKGFL SGLLDNIKQE LAKNKEMKES IKKFRDEAKK LEESDALQEA RRKYKSIESE TVRTSEAIKK KLGELTGTVK ESLDEVSKSD LGRKIKEGVE EAARTAKQSA ESVSKSGEKL GKTAAFKAIS QGVESVKKEL DESVLGQTGP YRRPERLRKR TEFAGAKFKE SKVFEANEEA LGVVLHKDSK WYQQWKDFKD NNVVFNRFFE MKMKYDESDN VLIRASRALT DKVTDLLGGL FSKTEMSEVL TEILRVDPTF DKDHFLHQCE TDIIPNILEA MISGELDILK DWCYEATYSQ LAHPIQQAKA LGFQFHSRIL DISNVDLAMG KMMEQGPVLI VTFQAQVVMV IKNSKGEVYD GDPDKVQRML YVWALCRDQE ELNPYAAWRL LDISASSTEQ IL //