ID TIM44_MOUSE STANDARD; PRT; 452 AA. AC O35857; DT 15-JUL-1999 (Rel. 38, Created) DT 15-JUL-1999 (Rel. 38, Last sequence update) DT 24-JAN-2006 (Rel. 49, Last annotation update) DE Import inner membrane translocase subunit TIM44, mitochondrial DE precursor. GN Name=Timm44; Synonyms=Mimt44, Tim44; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; OC Muroidea; Muridae; Murinae; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=CD-1; TISSUE=Kidney; RX MEDLINE=98081841; PubMed=9419343; DOI=10.1073/pnas.95.1.144; RA Wada J., Kanwar Y.S.; RT "Characterization of mammalian translocase of inner mitochondrial RT membrane (Tim44) isolated from diabetic newborn mouse kidney."; RL Proc. Natl. Acad. Sci. U.S.A. 95:144-149(1998). CC -!- FUNCTION: Involved in protein import into the mitochondrion. CC Probably involved in translocation across the inner membrane. As a CC binding protein required for driving the import of preproteins. CC Recruits mitochondrial HSP70 to drive protein translocation into CC the matrix using ATP as an energy source. CC -!- SUBUNIT: Forms part of the receptor complex that consists of at CC least 3 different proteins (TIM17, TIM23, TIM44) (By similarity). CC -!- SUBCELLULAR LOCATION: Mitochondrial inner membrane. CC -!- SIMILARITY: Belongs to the Tim44 family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U69898; AAB97624.1; -; mRNA. DR Ensembl; ENSMUSG00000002949; Mus musculus. DR MGI; MGI:1343262; Timm44. DR GO; GO:0005739; C:mitochondrion; IDA. DR InterPro; IPR007379; Tim44. DR InterPro; IPR005682; Tim44_sub. DR Pfam; PF04280; Tim44; 1. DR TIGRFAMs; TIGR00984; 3a0801s03tim44; 1. KW ATP-binding; Inner membrane; Membrane; Mitochondrion; KW Nucleotide-binding; Protein transport; Transit peptide; Translocation; KW Transport. FT TRANSIT 1 ? Mitochondrion. FT CHAIN ? 452 Import inner membrane translocase subunit FT TIM44. FT /FTId=PRO_0000034315. FT NP_BIND 166 173 ATP (Potential). SQ SEQUENCE 452 AA; 51176 MW; 18E2F61356F7B9F4 CRC64; MAAARLRGGW CRCPRRCLGS GIQFLSSHNL PHGSSYQISR PGRELTLTKS YSSGSRKGFL SGLLDNIKQE LAKNKEMKES IKKFRDEAKK LEESDALQEA RRKYKSIESE TVRTSEAIKK KLGELTGTVK ESLDEVSKSD LGRKIKEGVE EAARTAKQSA ESVSKSGEKL GKTAAFKAIS QGVESVKKEL DESVLGQTGP YRRPERLRKR TEFAGAKFKE SKVFEANEEA LGVVLHKDSK WYQQWKDFKD NNVVFNRFFE MKMKYDESDN VLIRASRALT DKVTDLLGGL FSKTEMSEVL TEILRVDPTF DKDHFLHQCE TDIIPNILEA MISGELDILK DWCYEATYSQ LAHPIQQAKA LGFQFHSRIL DISNVDLAMG KMMEQGPVLI VTFQAQVVMV IKNSKGEVYD GDPDKVQRML YVWALCRDQE ELNPYAAWRL LDISASSTEQ IL //