ID   RT12_MOUSE              Reviewed;         139 AA.
AC   O35680;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   13-SEP-2023, entry version 166.
DE   RecName: Full=Small ribosomal subunit protein uS12m {ECO:0000305};
DE   AltName: Full=28S ribosomal protein S12, mitochondrial;
DE            Short=MRP-S12;
DE            Short=S12mt;
DE   AltName: Full=MT-RPS12;
DE   Flags: Precursor;
GN   Name=Mrps12; Synonyms=Rpms12;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=9434165; DOI=10.1016/s0378-1119(97)00521-0;
RA   Shah Z.H., O'Dell K.M., Miller S.C.M., An X., Jacobs H.T.;
RT   "Metazoan nuclear genes for mitoribosomal protein S12.";
RL   Gene 204:55-62(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II, and FVB/N; TISSUE=Colon, and Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Component of the mitochondrial ribosome small subunit (28S)
CC       which comprises a 12S rRNA and about 30 distinct proteins.
CC       {ECO:0000250|UniProtKB:O15235}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O15235}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS12 family.
CC       {ECO:0000305}.
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DR   EMBL; Y11682; CAA72378.1; -; mRNA.
DR   EMBL; BC012679; AAH12679.1; -; mRNA.
DR   EMBL; BC027522; AAH27522.1; -; mRNA.
DR   CCDS; CCDS21052.1; -.
DR   RefSeq; NP_036015.1; NM_011885.4.
DR   RefSeq; XP_006539971.1; XM_006539908.2.
DR   PDB; 7PNT; EM; 3.19 A; J=1-139.
DR   PDB; 7PNU; EM; 3.06 A; J=1-139.
DR   PDB; 7PNV; EM; 3.06 A; J=1-139.
DR   PDB; 7PNW; EM; 3.09 A; J=1-139.
DR   PDBsum; 7PNT; -.
DR   PDBsum; 7PNU; -.
DR   PDBsum; 7PNV; -.
DR   PDBsum; 7PNW; -.
DR   AlphaFoldDB; O35680; -.
DR   SMR; O35680; -.
DR   BioGRID; 204858; 22.
DR   ComplexPortal; CPX-5301; 28S mitochondrial small ribosomal subunit.
DR   IntAct; O35680; 1.
DR   MINT; O35680; -.
DR   STRING; 10090.ENSMUSP00000062066; -.
DR   iPTMnet; O35680; -.
DR   PhosphoSitePlus; O35680; -.
DR   EPD; O35680; -.
DR   MaxQB; O35680; -.
DR   PaxDb; O35680; -.
DR   PeptideAtlas; O35680; -.
DR   ProteomicsDB; 256634; -.
DR   Antibodypedia; 30241; 212 antibodies from 26 providers.
DR   DNASU; 24030; -.
DR   Ensembl; ENSMUST00000056078; ENSMUSP00000062066; ENSMUSG00000045948.
DR   Ensembl; ENSMUST00000171183; ENSMUSP00000132443; ENSMUSG00000045948.
DR   GeneID; 24030; -.
DR   KEGG; mmu:24030; -.
DR   UCSC; uc009fzo.1; mouse.
DR   AGR; MGI:1346333; -.
DR   CTD; 6183; -.
DR   MGI; MGI:1346333; Mrps12.
DR   VEuPathDB; HostDB:ENSMUSG00000045948; -.
DR   eggNOG; KOG1750; Eukaryota.
DR   GeneTree; ENSGT00550000075103; -.
DR   HOGENOM; CLU_104295_3_1_1; -.
DR   InParanoid; O35680; -.
DR   OMA; MHRQGPP; -.
DR   OrthoDB; 275732at2759; -.
DR   PhylomeDB; O35680; -.
DR   TreeFam; TF315095; -.
DR   Reactome; R-MMU-5389840; Mitochondrial translation elongation.
DR   Reactome; R-MMU-5419276; Mitochondrial translation termination.
DR   BioGRID-ORCS; 24030; 23 hits in 78 CRISPR screens.
DR   ChiTaRS; Mrps12; mouse.
DR   PRO; PR:O35680; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; O35680; Protein.
DR   Bgee; ENSMUSG00000045948; Expressed in right kidney and 259 other tissues.
DR   ExpressionAtlas; O35680; baseline and differential.
DR   Genevisible; O35680; MM.
DR   GO; GO:0005743; C:mitochondrial inner membrane; NAS:ComplexPortal.
DR   GO; GO:0005763; C:mitochondrial small ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0005840; C:ribosome; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR   GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   CDD; cd03368; Ribosomal_S12; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR006032; Ribosomal_S12/S23.
DR   InterPro; IPR005679; Ribosomal_S12_bac.
DR   NCBIfam; TIGR00981; rpsL_bact; 1.
DR   PANTHER; PTHR11652:SF1; 28S RIBOSOMAL PROTEIN S12, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11652; 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER; 1.
DR   Pfam; PF00164; Ribosom_S12_S23; 1.
DR   PRINTS; PR01034; RIBOSOMALS12.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR   PROSITE; PS00055; RIBOSOMAL_S12; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Mitochondrion; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; Transit peptide.
FT   TRANSIT         1..29
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..139
FT                   /note="Small ribosomal subunit protein uS12m"
FT                   /id="PRO_0000030607"
SQ   SEQUENCE   139 AA;  15437 MW;  B365FE940025EA08 CRC64;
     MSWPGLLYGL TTSLSRGLAL APQLWAARSM ATLNQMHRLG PRKEPPKRLG PTEGRPQLKG
     VVLRTFIRKP KKPNSANRKC CRVRLSTGKE AVCFIPGEGH TLQEHHVVLV EGGRTQDLPG
     VKLKVVRGKY DCGHVQKKK
//