ID HISX_BACSU STANDARD; PRT; 427 AA. AC O34651; DT 15-JUL-1998 (Rel. 36, Created) DT 15-JUL-1998 (Rel. 36, Last sequence update) DT 15-MAR-2004 (Rel. 43, Last annotation update) DE Histidinol dehydrogenase (EC 1.1.1.23) (HDH). GN HISD OR BSU34910. OS Bacillus subtilis. OC Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus. OX NCBI_TaxID=1423; RN [1] RP SEQUENCE FROM N.A. RA Lazarevic V., Soldo B., Rivolta C., Reynolds S., Mauel C., RA Karamata D.; RT "Nucleotide sequence of the 300-304 chromosomal segment of Bacillus RT subtilis."; RL Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases. RN [2] RP SEQUENCE FROM N.A. RC STRAIN=168; RX MEDLINE=98044033; PubMed=9384377; RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., RA Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., RA Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., RA Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., RA Choi S.K., Codani J.J., Connerton I.F., Cummings N.J., Daniel R.A., RA Denizot F., Devine K.M., Dusterhoft A., Ehrlich S.D., Emmerson P.T., RA Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., RA Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., RA Ghim S.Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., RA Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., RA Hilbert H., Holsappel S., Hosono S., Hullo M.F., Itaya M., Jones L., RA Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., RA Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., RA Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., RA Lee S.M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., RA Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., RA Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.H., RA Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., RA Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., RA Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., RA Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.S., Soldo B., RA Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., RA Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., RA Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., RA Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., RA Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., RA Yoshida K., Yoshikawa H.F., Zumstein E., Yoshikawa H., Danchin A.; RT "The complete genome sequence of the Gram-positive bacterium Bacillus RT subtilis."; RL Nature 390:249-256(1997). CC -!- FUNCTION: Catalyzes the sequential NAD-dependent oxidations of L- CC histidinol to L-histidinaldehyde and then to L-histidine (By CC similarity). CC -!- CATALYTIC ACTIVITY: L-histidinol + 2 NAD(+) + H(2)O = L-histidine CC + 2 NADH. CC -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity). CC -!- PATHWAY: Histidine biosynthesis; ninth (last) step. CC -!- SIMILARITY: Belongs to the histidinol dehydrogenase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF017113; AAC67295.1; -. DR EMBL; Z99121; CAB15496.1; -. DR PIR; A69641; A69641. DR SubtiList; BG12599; hisD. DR HAMAP; MF_01024; -; 1. DR InterPro; IPR001692; Histidinol_dh. DR Pfam; PF00815; Histidinol_dh; 1. DR PRINTS; PR00083; HOLDHDRGNASE. DR ProDom; PD002680; Histidinol_dh; 1. DR TIGRFAMs; TIGR00069; hisD; 1. DR PROSITE; PS00611; HISOL_DEHYDROGENASE; 1. KW Histidine biosynthesis; Oxidoreductase; NAD; Metal-binding; Zinc; KW Complete proteome. FT ACT_SITE 321 321 By similarity. FT ACT_SITE 322 322 By similarity. FT METAL 253 253 ZINC (BY SIMILARITY). FT METAL 256 256 ZINC (BY SIMILARITY). FT METAL 355 355 ZINC (BY SIMILARITY). FT METAL 414 414 ZINC (BY SIMILARITY). SQ SEQUENCE 427 AA; 46256 MW; BDB0B2AE3C580E7F CRC64; MKIKTISGAE RLSLKRSIDA GTEEQRKTVR SIIEDVKANG DQAVRSYTAK FDCIEIDSPL VTKEEFEEAY TSLDSRLLQV IRQAIENIRE YHERQLQSSW FYHRKDGTML GQKVTALDSA GVYVPGGTAA YPSSVLMNVI PALVAGVERI VLVTPPGKDG LLSPGVLVAA AELGIKDIYK MGGAQAIAAL AYGTETIEPV DKITGPGNIY VALAKREVFG DVDIDMIAGP SEIVVLADET AIPSEIAADL LSQAEHDKLS SCVFVTDSMA LAETVSAEVN KQLETLPRRE IAEASVRDYG CIYVAETMVE AIETVNTLAP EHLEIITQSP EALLGSIKHA GAIFLGRYSP EPVGDYFAGP NHVLPTNGTA RFSSPLNVTD FQKKSSIISY SQSAFEEHAE SIAAFARLEG LEAHARSIEA RERRISK //