ID O25100_HELPY Unreviewed; 270 AA. AC O25100; DT 01-JAN-1998, integrated into UniProtKB/TrEMBL. DT 01-JAN-1998, sequence version 1. DT 25-MAY-2022, entry version 99. DE SubName: Full=DNA processing chain A (DprA) {ECO:0000313|EMBL:AAD07402.1}; GN OrderedLocusNames=HP_0333 {ECO:0000313|EMBL:AAD07402.1}; OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori). OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; OC Helicobacteraceae; Helicobacter. OX NCBI_TaxID=85962 {ECO:0000313|EMBL:AAD07402.1, ECO:0000313|Proteomes:UP000000429}; RN [1] {ECO:0000313|EMBL:AAD07402.1, ECO:0000313|Proteomes:UP000000429} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 700392 / 26695 {ECO:0000313|Proteomes:UP000000429}; RX PubMed=9252185; DOI=10.1038/41483; RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G., RA Fleischmann R.D., Ketchum K.A., Klenk H.P., Gill S., Dougherty B.A., RA Nelson K., Quackenbush J., Zhou L., Kirkness E.F., Peterson S., Loftus B., RA Richardson D., Dodson R., Khalak H.G., Glodek A., McKenney K., RA Fitzegerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E., Gocayne J.D., RA Utterback T.R., Peterson J.D., Kelley J.M., Karp P.D., Smith H.O., RA Fraser C.M., Venter J.C.; RT "The complete genome sequence of the gastric pathogen Helicobacter RT pylori."; RL Nature 388:539-547(1997). RN [2] {ECO:0007829|PDB:4LJK, ECO:0007829|PDB:4LJL} RP X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 5-217. RX PubMed=24369431; DOI=10.1093/nar/gkt1334; RA Wang W., Ding J., Zhang Y., Hu Y., Wang D.C.; RT "Structural insights into the unique single-stranded DNA-binding mode of RT Helicobacter pylori DprA."; RL Nucleic Acids Res. 42:3478-3491(2014). RN [3] {ECO:0007829|PDB:5MLL} RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 3-221. RX PubMed=30771270; DOI=10.1111/febs.14788; RA Lisboa J., Celma L., Sanchez D., Marquis M., Andreani J., Guerois R., RA Ochsenbein F., Durand D., Marsin S., Cuniasse P., Radicella J.P., RA Quevillon-Cheruel S.; RT "The C-terminal domain of HpDprA is a DNA-binding winged helix domain that RT does not bind double-stranded DNA."; RL FEBS J. 286:1941-1958(2019). CC -!- SIMILARITY: Belongs to the DprA/Smf family. CC {ECO:0000256|ARBA:ARBA00006525}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE000511; AAD07402.1; -; Genomic_DNA. DR PIR; E64561; E64561. DR RefSeq; NP_207131.1; NC_000915.1. DR RefSeq; WP_001076175.1; NC_018939.1. DR PDB; 4LJK; X-ray; 2.35 A; A/B/C/D/E/F/G/H=5-225. DR PDB; 4LJL; X-ray; 2.20 A; A/B=5-225. DR PDB; 4LJR; X-ray; 1.80 A; A/B=5-217. DR PDB; 5MLL; X-ray; 1.90 A; A/B=3-221. DR PDBsum; 4LJK; -. DR PDBsum; 4LJL; -. DR PDBsum; 4LJR; -. DR PDBsum; 5MLL; -. DR AlphaFoldDB; O25100; -. DR SMR; O25100; -. DR STRING; 85962.C694_01685; -. DR PaxDb; O25100; -. DR DNASU; 900099; -. DR EnsemblBacteria; AAD07402; AAD07402; HP_0333. DR KEGG; hpy:HP_0333; -. DR PATRIC; fig|85962.8.peg.347; -. DR eggNOG; COG0758; Bacteria. DR OMA; YSKQHTI; -. DR PhylomeDB; O25100; -. DR Proteomes; UP000000429; Chromosome. DR GO; GO:0009294; P:DNA mediated transformation; IEA:InterPro. DR InterPro; IPR003488; DprA. DR PANTHER; PTHR43022; PTHR43022; 1. DR Pfam; PF02481; DNA_processg_A; 1. DR TIGRFAMs; TIGR00732; dprA; 1. PE 1: Evidence at protein level; KW 3D-structure {ECO:0007829|PDB:4LJK, ECO:0007829|PDB:4LJL}; KW Reference proteome {ECO:0000313|Proteomes:UP000000429}. SQ SEQUENCE 270 AA; 30470 MW; 5211BDC3F20A844C CRC64; MNQRMKSHFQ YSTLENIPKA FDILKDPPKK LYCVGDTKLL DTPLKVAIIG TRRPTPYSKQ HTITLARELA KNGAVIVSGG ALGVDIIAQE NALPKTIMLS PCSLDFIYPT NNHKVIQEIA QNGLILSEYE KDFMPIKGSF LARNRLVIAL SDVVIIPQAD LKSGSMSSAR LAQKYQKPLF VLPQRLNESD GTNELLEKGQ AQGIFNIQNF INTLLKDYHL KEMPEMEDEF LEYCAKNPSY EEAYLKFGDK LLEYELLGKI KRINHIVVLA //