ID O21449_DROPB PRELIMINARY; PRT; 160 AA. AC O21449; DT 01-JAN-1998, integrated into UniProtKB/TrEMBL. DT 01-JAN-1998, sequence version 1. DT 07-FEB-2006, entry version 32. DE Cytochrome oxidase subunit I (Fragment). GN Name=mt:CoI; Synonyms=COI; OS Drosophila pseudoobscura bogotana (Fruit fly). OG Mitochondrion. OC Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; OC Ephydroidea; Drosophilidae; Drosophila. OX NCBI_TaxID=46244; RN [1] RP NUCLEOTIDE SEQUENCE. RC STRAIN=Bogota; RA Gleason J.M., Caccone A., Moriyama E.N., White K.P., Powell J.R.; RT "Mitochondrial DNA phylogenies for the Drosophila obscura group."; RL Evolution 51:433-440(1997). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B (By similarity). CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) = 4 ferricytochrome CC c + 2 H(2)O. CC -!- PATHWAY: Respiratory chain; terminal step. CC -!- SUBCELLULAR LOCATION: Integral membrane protein. Mitochondrial CC inner membrane (By similarity). CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U51607; AAB68484.1; -; Genomic_DNA. DR SMR; O21449; 1-159. DR FlyBase; FBgn0021234; Dpsb\mt:CoI. DR GO; GO:0016021; C:integral to membrane; IEA. DR GO; GO:0016020; C:membrane; IEA. DR GO; GO:0005746; C:mitochondrial electron transport chain; IEA. DR GO; GO:0005739; C:mitochondrion; IEA. DR GO; GO:0019866; C:organelle inner membrane; IEA. DR GO; GO:0005507; F:copper ion binding; IEA. DR GO; GO:0004129; F:cytochrome-c oxidase activity; IEA. DR GO; GO:0016491; F:oxidoreductase activity; IEA. DR GO; GO:0006118; P:electron transport; IEA. DR InterPro; IPR000883; COX1. DR PANTHER; PTHR10422; COX1; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR PROSITE; PS50855; COX1; 1. DR PROSITE; PS00077; COX1_CUB; 1. KW Copper; Electron transport; Heme; Inner membrane; Membrane; KW Mitochondrion; Oxidoreductase; Respiratory chain; Transmembrane; KW Transport. FT NON_TER 1 1 FT NON_TER 160 160 SQ SEQUENCE 160 AA; 17595 MW; 9ED35D4F54A6DB5B CRC64; QHLFWFFGHP EVYILILPGF GMISHIISQE SGKKETFGSL GMIYAMLAIG LLGFIVWAHH MFTVGMDVDT RAYFTSATMI IAVPTGIKIF SWLATLHGAQ LSYSPAILWA LGFVFLFTVG GLTGVVLANS SVDIILHDTY YVVAHFHYVL SMGAVFAIMA //